SOX18

Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF3547
HMG box

stem cell fate specification
endocardium formation
endocardium morphogenesis
cardiac endothelial cell differentiation
endocardial cell differentiation
lymphatic endothelial cell differentiation
stem cell fate commitment
lymphangiogenesis
endocardium development
lymph vessel morphogenesis
mRNA transcription by RNA polymerase II
lymph vessel development
nuclear transcription factor complex
mRNA transcription
blood vessel endothelial cell migration
establishment of endothelial barrier
endothelial cell development
heart looping
endothelial cell migration
regulation of stem cell proliferation
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
vasculogenesis
hair follicle development
outflow tract morphogenesis
skin epidermis development
hair cycle process
molting cycle process
embryonic heart tube development
endothelial cell differentiation
epithelial cell migration
epithelium migration
cell fate specification
molting cycle
hair cycle
tissue migration
endothelium development
cardiocyte differentiation
determination of left/right symmetry
determination of bilateral symmetry