SPINK2

Entrez Summary: N/A
UniProt Summary: Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin. {ECO:0000269|PubMed:19422058}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Kazal 2
Kazal 1

negative regulation of serine-type endopeptidase activity
negative regulation of serine-type peptidase activity
regulation of serine-type peptidase activity
regulation of serine-type endopeptidase activity
acrosome assembly
secretory granule organization
endopeptidase inhibitor activity
acrosomal vesicle
serine-type endopeptidase inhibitor activity
cellular component assembly involved in morphogenesis
spermatid development
spermatid differentiation
negative regulation of endopeptidase activity
negative regulation of peptidase activity
germ cell development
vesicle organization
negative regulation of proteolysis
cellular process involved in reproduction in multicellular organism
regulation of endopeptidase activity
endomembrane system organization
regulation of peptidase activity
negative regulation of hydrolase activity
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
regulation of proteolysis
organelle assembly
negative regulation of catalytic activity
cellular component morphogenesis
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
anatomical structure formation involved in morphogenesis
multi-organism reproductive process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
reproductive process