SPTA1

Gene Information

Official Symbol: SPTA1
Official Name: spectrin alpha, erythrocytic 1
Aliases and Previous Symbols: N/A
Entrez ID: 6708
UniProt: P02549
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017].
UniProt Summary: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17113
Expression level (log2 read counts): 2.19

Expression Distribution

efhand Ca insen
Spectrin
SH3 1

intrinsic component of the cytoplasmic side of the plasma membrane
spectrin-associated cytoskeleton
spectrin
cuticular plate
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
actin filament capping
negative regulation of actin filament depolymerization
porphyrin-containing compound metabolic process
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
lymphocyte homeostasis
tetrapyrrole metabolic process
negative regulation of protein depolymerization
negative regulation of protein polymerization
leukocyte homeostasis
negative regulation of protein complex disassembly
regulation of protein depolymerization
plasma membrane organization
positive regulation of protein binding
positive regulation of T cell proliferation
structural constituent of cytoskeleton
regulation of protein complex disassembly
positive regulation of lymphocyte proliferation
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
negative regulation of cytoskeleton organization
regulation of cell shape
regulation of T cell proliferation
regulation of actin filament polymerization
positive regulation of binding
regulation of actin polymerization or depolymerization
regulation of actin filament length
homeostasis of number of cells
positive regulation of T cell activation
actin filament binding
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation