SYCE1
Gene Information
- Official Symbol: SYCE1
- Official Name: synaptonemal complex central element protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 93426
- UniProt: Q8N0S2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
- UniProt Summary: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. {ECO:0000250|UniProtKB:Q9D495}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11617
- Expression level (log2 read counts): -1.4
SYCE1 Expression in NALM6 Cells: -1.4
