SYTL2

Entrez Summary: The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mucus secretion
regulation of mucus secretion
neurexin family protein binding
exocytic vesicle
extrinsic component of plasma membrane
vesicle docking involved in exocytosis
phosphatase binding
phosphatidylserine binding
vesicle docking
exocytic process
phosphatidylinositol-4,5-bisphosphate binding
melanosome
negative regulation of phosphatase activity
negative regulation of dephosphorylation
Rab GTPase binding
organelle localization by membrane tethering
regulation of phosphatase activity
membrane docking
protein localization to plasma membrane
regulation of dephosphorylation
protein localization to cell periphery
positive regulation of secretion
negative regulation of hydrolase activity
protein localization to membrane
regulation of body fluid levels
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
organelle localization
negative regulation of catalytic activity
exocytosis
regulation of secretion
positive regulation of transport
intracellular protein transport
secretion by cell
export from cell
secretion
negative regulation of molecular function
regulation of hydrolase activity
protein transport
intracellular transport