TCF21

Entrez Summary: TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bronchiole development
metanephric glomerulus morphogenesis
branchiomeric skeletal muscle development
metanephric glomerulus vasculature morphogenesis
metanephric glomerular capillary formation
glomerulus vasculature morphogenesis
glomerular capillary formation
metanephric mesenchymal cell differentiation
metanephric glomerulus vasculature development
lung vasculature development
renal system vasculature morphogenesis
kidney vasculature morphogenesis
mesenchymal cell differentiation involved in kidney development
mesenchymal cell differentiation involved in renal system development
glomerulus morphogenesis
diaphragm development
metanephric glomerulus development
metanephric mesenchyme development
negative regulation of androgen receptor signaling pathway
cell differentiation involved in metanephros development
embryonic digestive tract morphogenesis
kidney mesenchyme development
glomerulus vasculature development
renal system vasculature development
kidney vasculature development
Sertoli cell differentiation
sex determination
bHLH transcription factor binding
regulation of androgen receptor signaling pathway
metanephric nephron development
spleen development
embryonic digestive tract development
negative regulation of intracellular steroid hormone receptor signaling pathway
cell differentiation involved in kidney development
lung alveolus development
lung morphogenesis
androgen receptor binding
branching involved in ureteric bud morphogenesis
digestive tract morphogenesis
E-box binding