TCFL5

Gene Information

Official Symbol: TCFL5
Official Name: transcription factor like 5
Aliases and Previous Symbols: N/A
Entrez ID: 10732
UniProt: Q9UL49
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Putative transcription factor. Isoform 3 may play a role in early spermatogenesis. {ECO:0000269|PubMed:9763657}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5863
Expression level (log2 read counts): 6.33

Expression Distribution

male germ cell nucleus
protein dimerization activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
male gamete generation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of transcription by RNA polymerase II
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
macromolecule biosynthetic process