TMEM67

Entrez Summary: The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008].
UniProt Summary: Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). {ECO:0000250, ECO:0000269|PubMed:17185389, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:19815549}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

filamin binding
negative regulation of centrosome duplication
MKS complex
negative regulation of centrosome cycle
ciliary transition zone
regulation of centrosome duplication
ciliary membrane
regulation of centrosome cycle
ubiquitin-dependent ERAD pathway
ERAD pathway
ciliary basal body-plasma membrane docking
unfolded protein binding
negative regulation of cytoskeleton organization
cytoplasmic vesicle membrane
organelle localization by membrane tethering
membrane docking
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
response to endoplasmic reticulum stress
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of cell cycle process
cilium assembly
proteasomal protein catabolic process
cilium organization
negative regulation of organelle organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cytoskeleton organization
modification-dependent macromolecule catabolic process
negative regulation of cell cycle
organelle localization
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
negative regulation of cellular component organization
regulation of cell cycle process
organelle assembly