TNFRSF13C

Gene Information

Official Symbol: TNFRSF13C
Official Name: TNF receptor superfamily member 13C
Aliases and Previous Symbols: N/A
Entrez ID: 115650
UniProt: Q96RJ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008].
UniProt Summary: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18184
Expression level (log2 read counts): 6.11

Expression Distribution

positive regulation of germinal center formation
B cell costimulation
regulation of germinal center formation
positive regulation of interferon-gamma biosynthetic process
regulation of interferon-gamma biosynthetic process
B cell homeostasis
positive regulation of B cell proliferation
lymphocyte homeostasis
T cell costimulation
lymphocyte costimulation
regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of cytokine biosynthetic process
leukocyte homeostasis
positive regulation of T cell proliferation
regulation of interferon-gamma production
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of adaptive immune response
regulation of cytokine biosynthetic process
tumor necrosis factor-mediated signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of T cell proliferation
regulation of adaptive immune response
positive regulation of B cell activation
homeostasis of number of cells
positive regulation of T cell activation
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
cellular response to tumor necrosis factor
positive regulation of cell-cell adhesion
response to tumor necrosis factor
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
positive regulation of lymphocyte activation