TRIB2

Gene Information

Official Symbol: TRIB2
Official Name: tribbles pseudokinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 28951
UniProt: Q92519
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). {ECO:0000250|UniProtKB:Q28283, ECO:0000250|UniProtKB:Q96RU8}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12567
Expression level (log2 read counts): 5.37

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp488	-1.76
UM131593 0.1μM R01 exp58	1.74
SNS-032 25μM R07 exp401	1.94
Nicotinamide 2000μM R01 exp50	2.17

Pkinase Tyr
Pkinase

negative regulation of interleukin-10 biosynthetic process
ubiquitin-protein transferase regulator activity
regulation of interleukin-10 biosynthetic process
mitogen-activated protein kinase kinase binding
negative regulation of interleukin-10 production
protein kinase inhibitor activity
negative regulation of cytokine biosynthetic process
negative regulation of fat cell differentiation
regulation of interleukin-10 production
nucleotide binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
regulation of cytokine biosynthetic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of fat cell differentiation
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
negative regulation of protein kinase activity
protein kinase activity
negative regulation of kinase activity
regulation of cellular protein catabolic process
negative regulation of cytokine production
negative regulation of transferase activity
ubiquitin protein ligase binding
transcription factor binding
regulation of MAP kinase activity
positive regulation of proteolysis
positive regulation of cellular catabolic process
cytoskeleton
regulation of protein catabolic process
negative regulation of protein phosphorylation
positive regulation of catabolic process
negative regulation of phosphorylation
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process