TRIM5

Gene Information

Official Symbol: TRIM5
Official Name: tripartite motif containing 5
Aliases and Previous Symbols: N/A
Entrez ID: 85363
UniProt: Q9C035
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12119
Expression level (log2 read counts): 5.18

Expression Distribution

Screen	Score
GSK-J5 1.5μM R08 exp484	1.75
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.77

SPRY
zf-C3HC4
zf-B box
TMF TATA bd

omegasome
signaling pattern recognition receptor activity
negative regulation of viral release from host cell
negative regulation of viral entry into host cell
regulation of lipopolysaccharide-mediated signaling pathway
regulation of viral entry into host cell
regulation of viral release from host cell
protein K63-linked ubiquitination
interferon-gamma-mediated signaling pathway
protein binding, bridging
negative regulation of viral life cycle
P-body
negative regulation of viral process
pattern recognition receptor signaling pathway
regulation of viral life cycle
positive regulation of NF-kappaB transcription factor activity
cellular response to interferon-gamma
response to interferon-gamma
positive regulation of I-kappaB kinase/NF-kappaB signaling
defense response to virus
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-protein transferase activity
activation of innate immune response
process utilizing autophagic mechanism
autophagy
positive regulation of DNA-binding transcription factor activity
response to virus
protein polyubiquitination
negative regulation of locomotion
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of DNA-binding transcription factor activity
regulation of innate immune response
protein kinase binding
positive regulation of defense response
positive regulation of multi-organism process