TSLP
Gene Information
- Official Symbol: TSLP
- Official Name: thymic stromal lymphopoietin
- Aliases and Previous Symbols: N/A
- Entrez ID: 85480
- UniProt: Q969D9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269|PubMed:11418668, ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:17242164}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of chemokine (C-C motif) ligand 1 production |
| regulation of chemokine (C-C motif) ligand 1 production |
| interleukin-7 receptor binding |
| positive regulation of macrophage colony-stimulating factor production |
| positive regulation of granulocyte colony-stimulating factor production |
| regulation of granulocyte colony-stimulating factor production |
| regulation of macrophage colony-stimulating factor production |
| positive regulation of interleukin-5 secretion |
| regulation of interleukin-5 secretion |
| positive regulation of interleukin-5 production |
| positive regulation of interleukin-13 production |
| interleukin-7-mediated signaling pathway |
| positive regulation of mast cell activation |
| regulation of interleukin-5 production |
| regulation of interleukin-13 production |
| cellular response to interleukin-7 |
| response to interleukin-7 |
| positive regulation of interleukin-10 production |
| regulation of mast cell activation |
| positive regulation of cytokine-mediated signaling pathway |
| regulation of interleukin-10 production |
| positive regulation of chemokine production |
| positive regulation of response to cytokine stimulus |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of chemokine production |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of receptor signaling pathway via STAT |
| positive regulation of interleukin-6 production |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| positive regulation of inflammatory response |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| regulation of cytokine-mediated signaling pathway |
| cytokine activity |
| regulation of response to cytokine stimulus |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of cytokine secretion |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| regulation of inflammatory response |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| regulation of peptide secretion |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| positive regulation of transport |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| positive regulation of protein modification process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cisplatin 0.35μM R06 exp273 | 1.82 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.56 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17960
- Expression level (log2 read counts): -7.68
Expression Distribution
TSLP Expression in NALM6 Cells: -7.68
