TXNDC5

Entrez Summary: N/A
UniProt Summary: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

isomerase activity
apoptotic cell clearance
cell redox homeostasis
azurophil granule lumen
lysosomal lumen
endoplasmic reticulum lumen
phagocytosis
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
negative regulation of apoptotic process
cellular homeostasis
negative regulation of programmed cell death
leukocyte activation
negative regulation of cell death
secretion by cell
endoplasmic reticulum
export from cell
cell activation
immune effector process
secretion
regulation of apoptotic process
regulation of programmed cell death
homeostatic process
regulation of cell death
immune response
extracellular region
vesicle-mediated transport