UNC5A

Gene Information
  • Official Symbol: UNC5A
  • Official Name: unc-5 netrin receptor A
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 90249
  • UniProt: Q6ZN44
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. {ECO:0000250|UniProtKB:O08721}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 8165
  • Expression level (log2 read counts): -5.01

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1