USP44

Gene Information

Official Symbol: USP44
Official Name: ubiquitin specific peptidase 44
Aliases and Previous Symbols: N/A
Entrez ID: 84101
UniProt: Q9H0E7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016].
UniProt Summary: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination. {ECO:0000269|PubMed:17443180, ECO:0000269|PubMed:22681888}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4986
Expression level (log2 read counts): -1.2

Expression Distribution

zf-UBP
UCH

negative regulation of ubiquitin protein ligase activity
regulation of mitotic spindle checkpoint
regulation of spindle checkpoint
regulation of mitotic cell cycle spindle assembly checkpoint
negative regulation of ubiquitin-protein transferase activity
regulation of ubiquitin protein ligase activity
regulation of cell cycle checkpoint
regulation of mitotic metaphase/anaphase transition
regulation of ubiquitin-protein transferase activity
regulation of metaphase/anaphase transition of cell cycle
thiol-dependent ubiquitinyl hydrolase activity
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
negative regulation of protein ubiquitination
regulation of sister chromatid segregation
negative regulation of protein modification by small protein conjugation or removal
regulation of chromosome segregation
thiol-dependent ubiquitin-specific protease activity
regulation of mitotic nuclear division
regulation of nuclear division
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
chromosome segregation
negative regulation of transferase activity
protein deubiquitination
protein modification by small protein removal
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of chromosome organization
proteasomal protein catabolic process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
negative regulation of protein modification process
cellular protein catabolic process
regulation of mitotic cell cycle