VAV1
Gene Information
- Official Symbol: VAV1
- Official Name: vav guanine nucleotide exchange factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7409
- UniProt: P15498
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Pfam Domains GO Terms
Pfam Domains
| SH3 1 |
| PH |
| SH2 |
| C1 1 |
| RhoGEF |
| CH |
| CAMSAP CH |
| SH3 2 |
GO Terms
| Rac guanyl-nucleotide exchange factor activity |
| positive regulation of natural killer cell mediated cytotoxicity |
| positive regulation of natural killer cell mediated immunity |
| phosphotyrosine residue binding |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| T cell costimulation |
| lymphocyte costimulation |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of Ras protein signal transduction |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of cell killing |
| positive regulation of small GTPase mediated signal transduction |
| regulation of leukocyte mediated cytotoxicity |
| neutrophil chemotaxis |
| granulocyte chemotaxis |
| neutrophil migration |
| integrin-mediated signaling pathway |
| granulocyte migration |
| regulation of cell killing |
| guanyl-nucleotide exchange factor activity |
| positive regulation of lymphocyte mediated immunity |
| reactive oxygen species metabolic process |
| myeloid leukocyte migration |
| positive regulation of leukocyte mediated immunity |
| T cell differentiation |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| platelet activation |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of Rho protein signal transduction |
| leukocyte chemotaxis |
| regulation of lymphocyte mediated immunity |
| positive regulation of protein kinase B signaling |
| cell-cell junction |
| Fc-epsilon receptor signaling pathway |
| regulation of cell size |
| positive regulation of T cell activation |
| regulation of leukocyte mediated immunity |
| cell chemotaxis |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of protein kinase B signaling |
| T cell activation |
| lymphocyte differentiation |
| Fc receptor signaling pathway |
| regulation of Ras protein signal transduction |
| positive regulation of cell-cell adhesion |
| blood coagulation |
| coagulation |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| regulation of T cell activation |
| small GTPase mediated signal transduction |
| phagocytosis |
| leukocyte differentiation |
| positive regulation of innate immune response |
| regulation of small GTPase mediated signal transduction |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| regulation of cellular component size |
| leukocyte migration |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| regulation of body fluid levels |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| regulation of response to biotic stimulus |
| chemotaxis |
| taxis |
| hemopoiesis |
| immune response-activating signal transduction |
| response to wounding |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| positive regulation of immune response |
| leukocyte activation |
| cell migration |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of hydrolase activity |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of catalytic activity |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BVD-523 15μM R02 exp67 | -1.72 |
| Q15 2.7μM R02 exp79 | -1.71 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| NCK1 | 0.411 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5376
- Expression level (log2 read counts): 6.58
Expression Distribution
VAV1 Expression in NALM6 Cells: 6.58
