WNT1
Gene Information
- Official Symbol: WNT1
- Official Name: Wnt family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7471
- UniProt: P04628
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].
- UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (PubMed:23499309, PubMed:26902720, PubMed:28528193, PubMed:23656646). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis (PubMed:23499309, PubMed:23656646). {ECO:0000250|UniProtKB:P04426, ECO:0000269|PubMed:23499309, ECO:0000269|PubMed:23656646, ECO:0000269|PubMed:26902720, ECO:0000269|PubMed:28528193, ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| wnt |
GO Terms
| midbrain-hindbrain boundary maturation during brain development |
| astrocyte-dopaminergic neuron signaling |
| cerebellum formation |
| hindbrain formation |
| midbrain-hindbrain boundary maturation |
| glial cell-neuron signaling |
| central nervous system morphogenesis |
| positive regulation of dermatome development |
| forebrain anterior/posterior pattern specification |
| regulation of dermatome development |
| canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| Spemann organizer formation |
| cell proliferation in midbrain |
| neuron fate determination |
| ubiquitin-dependent SMAD protein catabolic process |
| morphogen activity |
| midbrain-hindbrain boundary development |
| Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| midbrain dopaminergic neuron differentiation |
| rostrocaudal neural tube patterning |
| embryonic brain development |
| hepatocyte differentiation |
| hematopoietic stem cell proliferation |
| positive regulation of insulin-like growth factor receptor signaling pathway |
| spinal cord association neuron differentiation |
| positive regulation of lamellipodium assembly |
| negative regulation of oxidative stress-induced neuron death |
| beta-catenin destruction complex disassembly |
| myoblast fusion |
| dorsal spinal cord development |
| regulation of insulin-like growth factor receptor signaling pathway |
| negative regulation of cell aging |
| forebrain regionalization |
| regulation of oxidative stress-induced neuron death |
| developmental induction |
| positive regulation of lamellipodium organization |
| dopaminergic neuron differentiation |
| regulation of lamellipodium assembly |
| receptor ligand activity |
| neural tube patterning |
| embryonic axis specification |
| syncytium formation by plasma membrane fusion |
| cell-cell fusion |
| positive regulation of embryonic development |
| cerebellum morphogenesis |
| syncytium formation |
| cell fate determination |
| frizzled binding |
| hindbrain morphogenesis |
| regulation of lamellipodium organization |
| branching involved in ureteric bud morphogenesis |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of fat cell differentiation |
| T cell differentiation in thymus |
| negative regulation of response to oxidative stress |
| negative regulation of ubiquitin-dependent protein catabolic process |
| regulation of cell aging |
| negative regulation of BMP signaling pathway |
| positive regulation of fibroblast proliferation |
| positive regulation of Notch signaling pathway |
| ureteric bud morphogenesis |
| stem cell proliferation |
| cell differentiation in spinal cord |
| mesonephric tubule morphogenesis |
| myotube differentiation |
| embryonic pattern specification |
| negative regulation of cell-substrate adhesion |
| regulation of oxidative stress-induced cell death |
| nephron tubule morphogenesis |
| neuron fate commitment |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| endocytic vesicle membrane |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| animal organ regeneration |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| neural precursor cell proliferation |
| regulation of cellular response to oxidative stress |
| diencephalon development |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| nephron tubule development |
| renal tubule development |
| regulation of fibroblast proliferation |
| regulation of response to oxidative stress |
| kidney morphogenesis |
| midbrain development |
| ureteric bud development |
| axis specification |
| mesonephric tubule development |
| mesonephric epithelium development |
| negative regulation of cellular protein catabolic process |
| regulation of BMP signaling pathway |
| canonical Wnt signaling pathway |
| mesonephros development |
| Wnt signaling pathway, planar cell polarity pathway |
| nephron epithelium development |
| inner ear morphogenesis |
| positive regulation of plasma membrane bounded cell projection assembly |
| Golgi lumen |
| cerebellum development |
| regulation of Notch signaling pathway |
| signal transduction in response to DNA damage |
| spinal cord development |
| regulation of establishment of planar polarity |
| metencephalon development |
| regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| ear morphogenesis |
| regulation of fat cell differentiation |
| nephron development |
| liver development |
| kidney epithelium development |
| hepaticobiliary system development |
| regulation of embryonic development |
| branching morphogenesis of an epithelial tube |
| negative regulation of protein catabolic process |
| non-canonical Wnt signaling pathway |
| T cell differentiation |
| anatomical structure maturation |
| negative regulation of cellular response to growth factor stimulus |
| hindbrain development |
| regulation of ubiquitin-dependent protein catabolic process |
| regeneration |
| morphogenesis of a branching epithelium |
| neural tube development |
| morphogenesis of a branching structure |
| cytokine activity |
| negative regulation of cell-cell adhesion |
| central nervous system neuron differentiation |
| regulation of morphogenesis of an epithelium |
| inner ear development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of plasma membrane bounded cell projection assembly |
| bone development |
| striated muscle cell differentiation |
| regulation of cell projection assembly |
| negative regulation of neuron death |
| regulation of cell-substrate adhesion |
| regulation of proteolysis involved in cellular protein catabolic process |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| ear development |
| T cell activation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| lymphocyte differentiation |
| developmental maturation |
| protein-containing complex disassembly |
| protein domain specific binding |
| muscle cell differentiation |
| cell fate commitment |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of DNA-binding transcription factor activity |
| cellular response to peptide hormone stimulus |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell adhesion |
| renal system development |
| embryonic organ morphogenesis |
| endoplasmic reticulum lumen |
| epithelial tube morphogenesis |
| negative regulation of catabolic process |
| regulation of neuron death |
| urogenital system development |
| cellular response to peptide |
| leukocyte differentiation |
| regionalization |
| negative regulation of proteolysis |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| positive regulation of cell projection organization |
| lymphocyte activation |
| regulation of protein catabolic process |
| forebrain development |
| response to peptide hormone |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| gland development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| response to peptide |
| muscle structure development |
| skeletal system development |
| positive regulation of cellular component biogenesis |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| sensory organ development |
| cell population proliferation |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| proteolysis involved in cellular protein catabolic process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| cellular protein catabolic process |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| cellular response to nitrogen compound |
| regulation of cell adhesion |
| epithelial cell differentiation |
| protein catabolic process |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| regulation of cellular response to stress |
| brain development |
| cellular response to DNA damage stimulus |
| head development |
| regulation of cellular catabolic process |
| tube development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| embryo development |
| central nervous system development |
| regulation of catabolic process |
| negative regulation of cell death |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| cell activation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.2μM R02 exp64 | -1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2806
- Expression level (log2 read counts): -7.68
Expression Distribution
WNT1 Expression in NALM6 Cells: -7.68
