XKR8

Entrez Summary: N/A
UniProt Summary: Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis. {ECO:0000269|PubMed:23845944}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.05μM R00 exp7	-3.16
Genistein 15μM R07 exp360	1.73

phosphatidylserine exposure on apoptotic cell surface
engulfment of apoptotic cell
plasma membrane phospholipid scrambling
apoptotic process involved in development
apoptotic cell clearance
phospholipid translocation
lipid translocation
regulation of membrane lipid distribution
execution phase of apoptosis
phospholipid transport
plasma membrane organization
organophosphate ester transport
phagocytosis, engulfment
plasma membrane invagination
membrane invagination
lipid transport
lipid localization
phagocytosis
endomembrane system organization
organic anion transport
endocytosis
anion transport
import into cell
membrane organization
apoptotic process
programmed cell death
cell death
ion transport
vesicle-mediated transport
membrane