ZADH2

Entrez Summary: N/A
UniProt Summary: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. {ECO:0000250|UniProtKB:Q8BGC4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADH N
ADH zinc N

13-prostaglandin reductase activity
15-oxoprostaglandin 13-oxidase activity
prostanoid metabolic process
prostaglandin metabolic process
negative regulation of fat cell differentiation
unsaturated fatty acid metabolic process
peroxisome
icosanoid metabolic process
regulation of fat cell differentiation
fatty acid derivative metabolic process
fatty acid metabolic process
monocarboxylic acid metabolic process
negative regulation of cell differentiation
molecular function
zinc ion binding
carboxylic acid metabolic process
negative regulation of developmental process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
regulation of cell differentiation