ZBED3

Gene Information

Official Symbol: ZBED3
Official Name: zinc finger BED-type containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 84327
UniProt: Q96IU2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4375
Expression level (log2 read counts): 5.08

Expression Distribution

Screen	Score
AICAR 240μM R05 exp211	1.7
Demecolcine 0.03μM R05 exp228	1.81

positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
protein stabilization
regulation of canonical Wnt signaling pathway
regulation of protein stability
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
negative regulation of protein phosphorylation
cell surface receptor signaling pathway involved in cell-cell signaling
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
cell-cell signaling
positive regulation of transcription by RNA polymerase II
regulation of protein phosphorylation
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of phosphorylation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of signal transduction
positive regulation of RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of protein modification process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
positive regulation of biosynthetic process