ZFYVE16

Entrez Summary: N/A
UniProt Summary: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Doxorubicin 0.02μM R08 exp478	-2.07
Betulinic acid 10 to 15μM on day4 R05 exp222	1.91

FYVE
DUF3480

1-phosphatidylinositol binding
protein targeting to lysosome
protein targeting to vacuole
protein localization to lysosome
phosphatidylinositol-3,4,5-trisphosphate binding
establishment of protein localization to vacuole
protein localization to vacuole
BMP signaling pathway
cellular response to BMP stimulus
response to BMP
lysosomal transport
vacuolar transport
early endosome membrane
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of endocytosis
endosomal transport
early endosome
vesicle organization
protein targeting
establishment of protein localization to organelle
cellular response to growth factor stimulus
response to growth factor
regulation of vesicle-mediated transport
intracellular membrane-bounded organelle
enzyme linked receptor protein signaling pathway
protein localization to organelle
intracellular protein transport
cellular response to endogenous stimulus
response to endogenous stimulus
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
regulation of transport
vesicle-mediated transport