CNOT6L

Gene Information

Official Symbol: CNOT6L
Official Name: CCR4-NOT transcription complex subunit 6 like
Aliases and Previous Symbols: N/A
Entrez ID: 246175
UniProt: Q96LI5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18872
Expression level (log2 read counts): 5.09

Expression Distribution

LRR 4
Exo endo phos

positive regulation of cytoplasmic mRNA processing body assembly
regulation of cytoplasmic mRNA processing body assembly
poly(A)-specific ribonuclease activity
CCR4-NOT complex
nuclear-transcribed mRNA poly(A) tail shortening
mRNA destabilization
3-5-exoribonuclease activity
RNA destabilization
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of mRNA catabolic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction involved in mitotic DNA damage checkpoint
signal transduction involved in mitotic G1 DNA damage checkpoint
signal transduction involved in mitotic cell cycle checkpoint
signal transduction involved in mitotic DNA integrity checkpoint
intracellular signal transduction involved in G1 DNA damage checkpoint
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
mitotic G1/S transition checkpoint
mitotic G1 DNA damage checkpoint
G1 DNA damage checkpoint
signal transduction involved in DNA integrity checkpoint
signal transduction involved in DNA damage checkpoint
signal transduction involved in cell cycle checkpoint
positive regulation of organelle assembly
positive regulation of mRNA metabolic process
DNA damage response, signal transduction by p53 class mediator
positive regulation of cell cycle arrest
gene silencing by RNA
mitotic DNA damage checkpoint
negative regulation of G1/S transition of mitotic cell cycle
signal transduction in response to DNA damage
mitotic DNA integrity checkpoint
negative regulation of cell cycle G1/S phase transition
regulation of cell cycle arrest
signal transduction by p53 class mediator
negative regulation of translation
DNA damage checkpoint
DNA integrity checkpoint
negative regulation of cellular amide metabolic process
regulation of G1/S transition of mitotic cell cycle