LPAR6

Gene Information

Official Symbol: LPAR6
Official Name: lysophosphatidic acid receptor 6
Aliases and Previous Symbols: N/A
Entrez ID: 10161
UniProt: P43657
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18383
Expression level (log2 read counts): 4.28

Expression Distribution

Screen	Score
FK-506 5μM R07 exp358	-1.76
Oligomycin-A 20μM R00 exp26	1.72
UMK57 1μM R01 exp59	1.73

organism emergence from protective structure
hatching
blastocyst hatching
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phospholipase C-activating G protein-coupled receptor signaling pathway
blastocyst development
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
in utero embryonic development
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
chordate embryonic development
cellular ion homeostasis
embryo development ending in birth or egg hatching
intracellular membrane-bounded organelle
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
embryo development
positive regulation of intracellular signal transduction
chemical homeostasis
G protein-coupled receptor signaling pathway
integral component of plasma membrane
homeostatic process
positive regulation of signal transduction
positive regulation of cell communication