NRD1

Entrez Summary: This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
UniProt Summary: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK2606414 1μM R05 exp236	-1.71
VER-155008 3.9μM R06 exp301	1.71

Peptidase M16
Peptidase M16 C

epidermal growth factor binding
positive regulation of membrane protein ectodomain proteolysis
regulation of membrane protein ectodomain proteolysis
neuromuscular junction development
negative regulation of cold-induced thermogenesis
metalloendopeptidase activity
regulation of cold-induced thermogenesis
positive regulation of protein catabolic process
synapse organization
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
regulation of endopeptidase activity
positive regulation of catabolic process
regulation of peptidase activity
cell population proliferation
cell surface
regulation of proteolysis
regulation of cellular catabolic process
cell migration
regulation of catabolic process
cell motility
localization of cell
negative regulation of multicellular organismal process
mitochondrion
proteolysis
regulation of hydrolase activity
locomotion
movement of cell or subcellular component
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process