https://crispr.tyerslab.com/ 2026-04-04T13:03:08+00:00 https://crispr.tyerslab.com/ https://crispr.tyerslab.com/_media/wiki/dokuwiki.svg text/html 2025-12-04T01:26:06+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/start?rev=1764811566&do=diff Welcome to the Chemical-Genetic Interaction Map Project * Home * Results * All Screens * Control Screens * Genes * Contact Us ---------- [ ] Overview Gene mutations that alter the response to drugs can inform chemical mechanism-of-action and reveal the underlying genetic network structure of the cell. More than text/html 2025-12-04T01:10:37+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/controls?rev=1764810637&do=diff Control Screens * Home * Results * All Screens * Control Screens * Genes * Contact Us ---------- Overview Total control screens: 65 * No treatment controls: 54 * Vehicle controls: 10 * Induction control: 1 ---------- Round 00 Controls in this round: 3 No Treatment Controls text/html 2025-12-04T01:10:18+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/results?rev=1764810618&do=diff Results * Home * Results * All Screens * Control Screens * Genes * Contact Us ---------- Displaying 413 screens. * Unique Compounds: 295 * Combinations: 7 * Proteins: 8 * Conditions: 5 ---------- Substance/ConditionExperimentsDescription/Target MechanismClassification text/html 2025-12-04T01:09:58+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/contact?rev=1764810598&do=diff Contact Us * Home * Results * All Screens * Control Screens * Genes * Contact Us ---------- [Location Map] Contacts Principal Investigator Mike Tyers mike.tyers@sickkids.ca Laboratory Manager María Sánchez Osuna maria.sanchezosuna@sickkids.ca Email us Address Program in Molecular Medicine Peter Gilgan Centre for Research and Learning text/html 2025-10-23T01:28:01+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/results/exp434?rev=1761182881&do=diff Vemurafenib 6.6μM R08 exp434 Mechanism of Action Inhibits BRAF-V300E, paradoxical RAF activation by stabilization of CRAF/BRAF heterodimer * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Vemurafenib text/html 2025-10-18T15:03:35+00:00 tyersadmin (tyersadmin@undisclosed.example.com) https://crispr.tyerslab.com/results/exp1?rev=1760799815&do=diff 5-Fluorouracil 2μM R00 exp1 Mechanism of Action Thymidylate synthase inhibitor, blocks DNA replication * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor Technical Notes