The Human Chemical-Genetic Interaction Map Project - wiki:results https://crispr.tyerslab.com/ 2026-04-04T18:22:58+00:00 The Human Chemical-Genetic Interaction Map Project https://crispr.tyerslab.com/ https://crispr.tyerslab.com/_media/wiki/dokuwiki.svg text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 5-Fluorouracil 2μM R00 exp1 https://crispr.tyerslab.com/wiki/results/exp1?rev=1767843420&do=diff 5-Fluorouracil 2μM R00 exp1 Mechanism of Action Thymidylate synthase inhibitor, blocks DNA replication * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 5-Fluorouracil 20μM R00 exp2 https://crispr.tyerslab.com/wiki/results/exp2?rev=1767843420&do=diff 5-Fluorouracil 20μM R00 exp2 Mechanism of Action Thymidylate synthase inhibitor, blocks DNA replication * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Actinomycin-D 0.001μM R00 exp3 https://crispr.tyerslab.com/wiki/results/exp3?rev=1767843420&do=diff Actinomycin-D 0.001μM R00 exp3 Mechanism of Action Inhibits RNA polymerases, intercalates DNA, prevents chain elongation * Class / Subclass 1: Gene Regulation / Transcription Inhibitor Technical Notes * PubChem Name: Dactinomycin * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Actinomycin-D 0.01μM R00 exp4 https://crispr.tyerslab.com/wiki/results/exp4?rev=1767843420&do=diff Actinomycin-D 0.01μM R00 exp4 Mechanism of Action Inhibits RNA polymerases, intercalates DNA, prevents chain elongation * Class / Subclass 1: Gene Regulation / Transcription Inhibitor Technical Notes * PubChem Name: Dactinomycin * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Alpha-Amanitin 0.5μM R00 exp5 https://crispr.tyerslab.com/wiki/results/exp5?rev=1767843420&do=diff Alpha-Amanitin 0.5μM R00 exp5 Mechanism of Action Inhibits RNA polymerase II and III, interferes with translocation * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Environmental Stresses / Toxin Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bortezomib 0.005μM R00 exp6 https://crispr.tyerslab.com/wiki/results/exp6?rev=1767843420&do=diff Bortezomib 0.005μM R00 exp6 Mechanism of Action Inhibits 26S proteasome, binds reversibly to chymotrypsin-like catalytic sites * Class / Subclass 1: Proteostasis / Proteasome Inhibitor Technical Notes * PubChem Name: Bortezomib * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bortezomib 0.05μM R00 exp7 https://crispr.tyerslab.com/wiki/results/exp7?rev=1767843420&do=diff Bortezomib 0.05μM R00 exp7 Mechanism of Action Inhibits 26S proteasome, binds reversibly to chymotrypsin-like catalytic sites * Class / Subclass 1: Proteostasis / Proteasome Inhibitor Technical Notes * PubChem Name: Bortezomib * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Brefeldin A 0.02μM R00 exp8 https://crispr.tyerslab.com/wiki/results/exp8?rev=1767843420&do=diff Brefeldin A 0.02μM R00 exp8 Mechanism of Action Inhibits Golgi to ER transport, forms uncompetitive complex with GBF1 and GDP-bound Arf1 * Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CCCP 0.1μM R00 exp10 https://crispr.tyerslab.com/wiki/results/exp10?rev=1767843420&do=diff CCCP 0.1μM R00 exp10 Mechanism of Action Mitochondrial proton gradient uncoupler, disrupts ATP synthesis * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor Technical Notes * PubChem Name: (3-Chlorophenyl)hydrazonomalononitrile text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CCCP 1μM R00 exp11 https://crispr.tyerslab.com/wiki/results/exp11?rev=1767843420&do=diff CCCP 1μM R00 exp11 Mechanism of Action Mitochondrial proton gradient uncoupler, disrupts ATP synthesis * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor Technical Notes * PubChem Name: (3-Chlorophenyl)hydrazonomalononitrile text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Chloramphenicol 2μM R00 exp12 https://crispr.tyerslab.com/wiki/results/exp12?rev=1767843420&do=diff Chloramphenicol 2μM R00 exp12 Mechanism of Action Binds 23S rRNA of 50S ribosomal subunit, inhibits protein synthesis * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Chloramphenicol 20μM R00 exp13 https://crispr.tyerslab.com/wiki/results/exp13?rev=1767843420&do=diff Chloramphenicol 20μM R00 exp13 Mechanism of Action Binds 23S rRNA of 50S ribosomal subunit, inhibits protein synthesis * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cycloheximide 0.02μM R00 exp14 https://crispr.tyerslab.com/wiki/results/exp14?rev=1767843420&do=diff Cycloheximide 0.02μM R00 exp14 Mechanism of Action Translation elongation inhibitor, binds 60S ribosomal subunit * Class / Subclass 1: Proteostasis / Translation Inhibitor * Class / Subclass 2: Environmental Stresses / Toxin Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cycloheximide 0.2μM R00 exp15 https://crispr.tyerslab.com/wiki/results/exp15?rev=1767843420&do=diff Cycloheximide 0.2μM R00 exp15 Mechanism of Action Translation elongation inhibitor, binds 60S ribosomal subunit * Class / Subclass 1: Proteostasis / Translation Inhibitor * Class / Subclass 2: Environmental Stresses / Toxin Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) DABN 2μM R00 exp16 https://crispr.tyerslab.com/wiki/results/exp16?rev=1767843420&do=diff DABN 2μM R00 exp16 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine * Synonyms: N/A * CAS #: 4488-22-6 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) DABN 20μM R00 exp17 https://crispr.tyerslab.com/wiki/results/exp17?rev=1767843420&do=diff DABN 20μM R00 exp17 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine * Synonyms: N/A * CAS #: 4488-22-6 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Doxycycline 10μM R00 exp18 https://crispr.tyerslab.com/wiki/results/exp18?rev=1767843420&do=diff Doxycycline 10μM R00 exp18 Mechanism of Action Inhibits bacterial 30S ribosome, also used in tet-on/tet-off gene expression control * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Etoposide 1μM R00 exp19 https://crispr.tyerslab.com/wiki/results/exp19?rev=1767843420&do=diff Etoposide 1μM R00 exp19 Mechanism of Action Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin * Class / Subclass 1: DNA Damage, Repair and Replication / Topoisomerase II Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Etoposide 10μM R00 exp20 https://crispr.tyerslab.com/wiki/results/exp20?rev=1767843420&do=diff Etoposide 10μM R00 exp20 Mechanism of Action Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin * Class / Subclass 1: DNA Damage, Repair and Replication / Topoisomerase II Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MLN-4924 0.2μM R00 exp21 https://crispr.tyerslab.com/wiki/results/exp21?rev=1767843420&do=diff MLN-4924 0.2μM R00 exp21 Mechanism of Action Inhibits NEDD8-activating enzyme (NAE), prevents activity of cullin-RING ligase (CRL) E3 enzymes * Class / Subclass 1: Proteostasis / NEDDylation Inhibitor Technical Notes * PubChem Name: Pevonedistat text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MLN-4924 2μM R00 exp22 https://crispr.tyerslab.com/wiki/results/exp22?rev=1767843420&do=diff MLN-4924 2μM R00 exp22 Mechanism of Action Inhibits NEDD8-activating enzyme (NAE), prevents activity of cullin-RING ligase (CRL) E3 enzymes * Class / Subclass 1: Proteostasis / NEDDylation Inhibitor Technical Notes * PubChem Name: Pevonedistat text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nocodazole 0.02μM R00 exp23 https://crispr.tyerslab.com/wiki/results/exp23?rev=1767843420&do=diff Nocodazole 0.02μM R00 exp23 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nocodazole 0.2μM R00 exp24 https://crispr.tyerslab.com/wiki/results/exp24?rev=1767843420&do=diff Nocodazole 0.2μM R00 exp24 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Oligomycin-A 2μM R00 exp25 https://crispr.tyerslab.com/wiki/results/exp25?rev=1767843420&do=diff Oligomycin-A 2μM R00 exp25 Mechanism of Action Inhibits F0 proton channel of mitochondrial ATP synthase, blocks electron flow through ETC * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor Technical Notes * PubChem Name: Oligomycin A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Oligomycin-A 20μM R00 exp26 https://crispr.tyerslab.com/wiki/results/exp26?rev=1767843420&do=diff Oligomycin-A 20μM R00 exp26 Mechanism of Action Inhibits F0 proton channel of mitochondrial ATP synthase, blocks electron flow through ETC * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor Technical Notes * PubChem Name: Oligomycin A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pimelic-diphenylamide-106 0.5μM R00 exp27 https://crispr.tyerslab.com/wiki/results/exp27?rev=1767843420&do=diff Pimelic-diphenylamide-106 0.5μM R00 exp27 Mechanism of Action Inhibits HDAC3 selectively, benzamide derivative * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Pimelic Diphenylamide 106 * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pimelic-diphenylamide-106 5μM R00 exp28 https://crispr.tyerslab.com/wiki/results/exp28?rev=1767843420&do=diff Pimelic-diphenylamide-106 5μM R00 exp28 Mechanism of Action Inhibits HDAC3 selectively, benzamide derivative * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Pimelic Diphenylamide 106 * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 1μM R00 exp29 https://crispr.tyerslab.com/wiki/results/exp29?rev=1767843420&do=diff Rapamycin 1μM R00 exp29 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 10μM R00 exp30 https://crispr.tyerslab.com/wiki/results/exp30?rev=1767843420&do=diff Rapamycin 10μM R00 exp30 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rifampicin 1μM R00 exp31 https://crispr.tyerslab.com/wiki/results/exp31?rev=1767843420&do=diff Rifampicin 1μM R00 exp31 Mechanism of Action Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Rifampicin * Synonyms: Rifampin; Rifamycin AMP text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rifampicin 10μM R00 exp32 https://crispr.tyerslab.com/wiki/results/exp32?rev=1767843420&do=diff Rifampicin 10μM R00 exp32 Mechanism of Action Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Rifampicin * Synonyms: Rifampin; Rifamycin AMP text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rotenone 2μM R00 exp33 https://crispr.tyerslab.com/wiki/results/exp33?rev=1767843420&do=diff Rotenone 2μM R00 exp33 Mechanism of Action Inhibits complex I, blocks electron transfer from iron-sulfur centers to ubiquinone, generates ROS, also inhibits microtubule assembly * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rotenone 20μM R00 exp34 https://crispr.tyerslab.com/wiki/results/exp34?rev=1767843420&do=diff Rotenone 20μM R00 exp34 Mechanism of Action Inhibits complex I, blocks electron transfer from iron-sulfur centers to ubiquinone, generates ROS, also inhibits microtubule assembly * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) TRAIL 5ng/ml R00 exp35 https://crispr.tyerslab.com/wiki/results/exp35?rev=1767843420&do=diff TRAIL 5ng/ml R00 exp35 Mechanism of Action TNF-related apoptosis-inducing ligand, TNF superfamily member, induces extrinsic apoptosis * Class / Subclass 1: Signal Transduction / Other Receptor Agonist Technical Notes * PubChem Name: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) TRAIL 50ng/ml R00 exp36 https://crispr.tyerslab.com/wiki/results/exp36?rev=1767843420&do=diff TRAIL 50ng/ml R00 exp36 Mechanism of Action TNF-related apoptosis-inducing ligand, TNF superfamily member, induces extrinsic apoptosis * Class / Subclass 1: Signal Transduction / Other Receptor Agonist Technical Notes * PubChem Name: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Wortmannin 0.5μM R00 exp37 https://crispr.tyerslab.com/wiki/results/exp37?rev=1767843420&do=diff Wortmannin 0.5μM R00 exp37 Mechanism of Action Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Proteostasis / Autophagy Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Wortmannin 5μM R00 exp38 https://crispr.tyerslab.com/wiki/results/exp38?rev=1767843420&do=diff Wortmannin 5μM R00 exp38 Mechanism of Action Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Proteostasis / Autophagy Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 2-Methoxyestradiol 0.2μM R01 exp40 https://crispr.tyerslab.com/wiki/results/exp40?rev=1767843420&do=diff 2-Methoxyestradiol 0.2μM R01 exp40 Mechanism of Action Endogenous estradiol metabolite, weak agonist for estrogen receptor, agonist of GPER1, microtubule destabilizer * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / GPCR Agonist text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-2536 0.001μM R01 exp41 https://crispr.tyerslab.com/wiki/results/exp41?rev=1767843420&do=diff BI-2536 0.001μM R01 exp41 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: BI-2536 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-6727 0.001μM R01 exp42 https://crispr.tyerslab.com/wiki/results/exp42?rev=1767843420&do=diff BI-6727 0.001μM R01 exp42 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest, improved version of BI-2536 * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Docetaxel 0.002μM R01 exp45 https://crispr.tyerslab.com/wiki/results/exp45?rev=1767843420&do=diff Docetaxel 0.002μM R01 exp45 Mechanism of Action Inihibts microtubule depolymerization, semi-synthetic analog of the paclitaxel * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) HMS-I1 1μM R01 exp46 https://crispr.tyerslab.com/wiki/results/exp46?rev=1767843420&do=diff HMS-I1 1μM R01 exp46 Mechanism of Action Inhibits HDAC * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-6-methylimidazo[1,2-a]pyridine * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Lapatinib 5μM R01 exp47 https://crispr.tyerslab.com/wiki/results/exp47?rev=1767843420&do=diff Lapatinib 5μM R01 exp47 Mechanism of Action Inhibits EGFR and ErbB2 receptor tyrosine kinases * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Lapatinib Ditosylate * Synonyms: GW-572016 ditosylate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Mubritinib 0.2μM R01 exp48 https://crispr.tyerslab.com/wiki/results/exp48?rev=1767843420&do=diff Mubritinib 0.2μM R01 exp48 Mechanism of Action Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Mubritinib * Synonyms: TAK-165 * CAS #: 366017-09-6 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NFN1 0.1μM R01 exp49 https://crispr.tyerslab.com/wiki/results/exp49?rev=1767843420&do=diff NFN1 0.1μM R01 exp49 Mechanism of Action Nitrofuran derivative, candidate ALDH2 inhibitor * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Ethyl 5-ethyl-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nicotinamide 2000μM R01 exp50 https://crispr.tyerslab.com/wiki/results/exp50?rev=1767843420&do=diff Nicotinamide 2000μM R01 exp50 Mechanism of Action NAD biosynthetic precursor, activates SIRT1 * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Nicotinamide * Synonyms: Niacinamide; Nicotinic acid amide; Vitamin B3 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nifuroxazide 1μM R01 exp51 https://crispr.tyerslab.com/wiki/results/exp51?rev=1767843420&do=diff Nifuroxazide 1μM R01 exp51 Mechanism of Action Nitrofuran antibiotic * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Nifuroxazide * Synonyms: N/A * CAS #: 965-52-6 * PubChem CID: 5337997 * IUPAC: 4-hydroxy-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ribavirin 10μM R01 exp52 https://crispr.tyerslab.com/wiki/results/exp52?rev=1767843420&do=diff Ribavirin 10μM R01 exp52 Mechanism of Action Prodrug metabolized to purine RNA nucleotide mimetic, also inhibits EIF4E * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: Metabolism / Antimetabolite * Class / Subclass 3: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53 https://crispr.tyerslab.com/wiki/results/exp53?rev=1767843420&do=diff Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53 Mechanism of Action Inhibits class I, II, IV HDACs, chelates active site zinc ion * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Vorinostat * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Taxol 0.002μM R01 exp54 https://crispr.tyerslab.com/wiki/results/exp54?rev=1767843420&do=diff Taxol 0.002μM R01 exp54 Mechanism of Action Inhibits microtubule depolymerisation, blocks metaphase to anaphase transition * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM131593 0.1μM R01 exp58 https://crispr.tyerslab.com/wiki/results/exp58?rev=1767843420&do=diff UM131593 0.1μM R01 exp58 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * IUPAC: N/A * INCHI Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UMK57 1μM R01 exp59 https://crispr.tyerslab.com/wiki/results/exp59?rev=1767843420&do=diff UMK57 1μM R01 exp59 Mechanism of Action Potentiates kinesin-13 (MCAK), destabilizes kinetochore-MT attachment, suppresses chromosome mis-segregation * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vinblastine 0.002μM R01 exp60 https://crispr.tyerslab.com/wiki/results/exp60?rev=1767843420&do=diff Vinblastine 0.002μM R01 exp60 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) YM155 0.0002μM R01 exp61 https://crispr.tyerslab.com/wiki/results/exp61?rev=1767843420&do=diff YM155 0.0002μM R01 exp61 Mechanism of Action Inhibits expression of survivin, amongst other ascribed mechanisms * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Apoptosis Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nocodazole 0.2μM R02 exp64 https://crispr.tyerslab.com/wiki/results/exp64?rev=1767843420&do=diff Nocodazole 0.2μM R02 exp64 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Mubritinib 0.2μM R02 exp65 https://crispr.tyerslab.com/wiki/results/exp65?rev=1767843420&do=diff Mubritinib 0.2μM R02 exp65 Mechanism of Action Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Mubritinib * Synonyms: TAK-165 * CAS #: 366017-09-6 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-D1870 3.15μM R02 exp66 https://crispr.tyerslab.com/wiki/results/exp66?rev=1767843420&do=diff BI-D1870 3.15μM R02 exp66 Mechanism of Action Inhibits ribosomal p90 S6 Kinase, active against RSK1/2/3/4 isoforms * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 2-((3,5-Difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BVD-523 15μM R02 exp67 https://crispr.tyerslab.com/wiki/results/exp67?rev=1767843420&do=diff BVD-523 15μM R02 exp67 Mechanism of Action Inhibits ERK1/2, ATP-competitive * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Ulixertinib * Synonyms: BVD-523; VRT752271 * CAS #: 869886-67-9 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Clomiphene 4.4μM R02 exp68 https://crispr.tyerslab.com/wiki/results/exp68?rev=1767843420&do=diff Clomiphene 4.4μM R02 exp68 Mechanism of Action Nonsteroidal selective estrogen receptor modulator (SERM), mixed agonist and antagonist of ER * Class / Subclass 1: Metabolism / Hormone Antagonist * Class / Subclass 2: Gene Regulation / Nuclear Receptor Ligand text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Deguelin 0.05μM R02 exp69 https://crispr.tyerslab.com/wiki/results/exp69?rev=1767843420&do=diff Deguelin 0.05μM R02 exp69 Mechanism of Action Derivative of rotenone, putative AKT inhibitor, complex I inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) INK128 0.2μM R02 exp70 https://crispr.tyerslab.com/wiki/results/exp70?rev=1767843420&do=diff INK128 0.2μM R02 exp70 Mechanism of Action Inhibits mTORC1 and mTORC2, ATP-competitive * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Proteostasis / mTOR inhibitor Technical Notes * PubChem Name: Sapanisertib text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) KU-0063794 3.8μM R02 exp71 https://crispr.tyerslab.com/wiki/results/exp71?rev=1767843420&do=diff KU-0063794 3.8μM R02 exp71 Mechanism of Action ATP-competitive mTORC1 and mTORC2 inhibitor * Class / Subclass 1: Proteostasis / mTOR inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Ku-0063794 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LB-100 4.1μM R02 exp72 https://crispr.tyerslab.com/wiki/results/exp72?rev=1767843420&do=diff LB-100 4.1μM R02 exp72 Mechanism of Action Inhibits protein phosphatase 2A * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: LB-100 * Synonyms: N/A * CAS #: 1026680-07-8 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LJH685 5μM R02 exp73 https://crispr.tyerslab.com/wiki/results/exp73?rev=1767843420&do=diff LJH685 5μM R02 exp73 Mechanism of Action Inhibits p90 ribosomal S6 kinase (RSK) * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MK-1775 0.32μM R02 exp75 https://crispr.tyerslab.com/wiki/results/exp75?rev=1767843420&do=diff MK-1775 0.32μM R02 exp75 Mechanism of Action Inhibits Wee1, alleviates CDK inhibition * Class / Subclass 1: Cell Cycle / Kinase Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor * Class / Subclass 3: DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Prochlorperazine 5.2μM R02 exp77 https://crispr.tyerslab.com/wiki/results/exp77?rev=1767843420&do=diff Prochlorperazine 5.2μM R02 exp77 Mechanism of Action Antagonist of DRD2 receptors, used to treat nausea, schizophrenia, migraines, anxiety * Class / Subclass 1: Signal Transduction / GPCR Antagonist Technical Notes * PubChem Name: Prochlorperazine maleate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pterostilbene 16μM R02 exp78 https://crispr.tyerslab.com/wiki/results/exp78?rev=1767843420&do=diff Pterostilbene 16μM R02 exp78 Mechanism of Action Putative sirtuin activator, anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, anti-obesity, analog of resveratrol * Class / Subclass 1: Gene Regulation / Epigenetic Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Q15 2.7μM R02 exp79 https://crispr.tyerslab.com/wiki/results/exp79?rev=1767843420&do=diff Q15 2.7μM R02 exp79 Mechanism of Action Putative condensin inhibitor * Class / Subclass 1: Cell Cycle / Chromosome Dynamics Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: 1071780-64-7 * PubChem CID: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) RO-3307 4.7μM R02 exp80 https://crispr.tyerslab.com/wiki/results/exp80?rev=1767843420&do=diff RO-3307 4.7μM R02 exp80 Mechanism of Action Inhibits CDK1, ATP-competitive, causes G2/M arrest * Class / Subclass 1: Cell Cycle / Kinase Inhibitor Technical Notes * PubChem Name: (5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Selumetinib 20μM R02 exp81 https://crispr.tyerslab.com/wiki/results/exp81?rev=1767843420&do=diff Selumetinib 20μM R02 exp81 Mechanism of Action Inhibits MEK1 and MEK2 * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Selumetinib * Synonyms: AZD6244; ARRY-142886 * CAS #: 606143-52-6 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Torin1 0.08μM R02 exp82 https://crispr.tyerslab.com/wiki/results/exp82?rev=1767843420&do=diff Torin1 0.08μM R02 exp82 Mechanism of Action Inhibits mTORC1 and mTORC2, ATP competitive * Class / Subclass 1: Proteostasis / mTOR inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Torin 1 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Trametinib 10μM R02 exp83 https://crispr.tyerslab.com/wiki/results/exp83?rev=1767843420&do=diff Trametinib 10μM R02 exp83 Mechanism of Action Inhibits MEK1 and MEK2, reversible allosteric mechanism, used in combination with BRAF V600E inhibitors * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0125461 0.74μM R02 exp84 https://crispr.tyerslab.com/wiki/results/exp84?rev=1767843420&do=diff UM0125461 0.74μM R02 exp84 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * IUPAC: N/A * INCHI Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0129480 7μM R02 exp85 https://crispr.tyerslab.com/wiki/results/exp85?rev=1767843420&do=diff UM0129480 7μM R02 exp85 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * IUPAC: N/A * INCHI Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vemurafenib 6.6μM R02 exp89 https://crispr.tyerslab.com/wiki/results/exp89?rev=1767843420&do=diff Vemurafenib 6.6μM R02 exp89 Mechanism of Action Inhibits BRAF-V300E, paradoxical RAF activation by stabilization of CRAF/BRAF heterodimer * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Vemurafenib text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) WYE-354 6μM R02 exp90 https://crispr.tyerslab.com/wiki/results/exp90?rev=1767843420&do=diff WYE-354 6μM R02 exp90 Mechanism of Action Inhibits mTORC1 and mTORC2, ATP-competitive inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Proteostasis / mTOR inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) DABN racemic mixture R03 exp93 https://crispr.tyerslab.com/wiki/results/exp93?rev=1767843420&do=diff DABN racemic mixture R03 exp93 Mechanism of Action Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes (R)-DABN * PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nocodazole 0.1μM R03 exp94 https://crispr.tyerslab.com/wiki/results/exp94?rev=1767843420&do=diff Nocodazole 0.1μM R03 exp94 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-2536 0.0042μM R03 exp95 https://crispr.tyerslab.com/wiki/results/exp95?rev=1767843420&do=diff BI-2536 0.0042μM R03 exp95 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: BI-2536 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-2536 0.02μM R03 exp96 https://crispr.tyerslab.com/wiki/results/exp96?rev=1767843420&do=diff BI-2536 0.02μM R03 exp96 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: BI-2536 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-6727 0.0125μM R03 exp97 https://crispr.tyerslab.com/wiki/results/exp97?rev=1767843420&do=diff BI-6727 0.0125μM R03 exp97 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest, improved version of BI-2536 * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-6727 0.04μM R03 exp98 https://crispr.tyerslab.com/wiki/results/exp98?rev=1767843420&do=diff BI-6727 0.04μM R03 exp98 Mechanism of Action Inhibits PLK1 kinase, causes G2/M arrest, improved version of BI-2536 * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NFN1 0.4μM R03 exp99 https://crispr.tyerslab.com/wiki/results/exp99?rev=1767843420&do=diff NFN1 0.4μM R03 exp99 Mechanism of Action Nitrofuran derivative, candidate ALDH2 inhibitor * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Ethyl 5-ethyl-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NFN1 1μM R03 exp100 https://crispr.tyerslab.com/wiki/results/exp100?rev=1767843420&do=diff NFN1 1μM R03 exp100 Mechanism of Action Nitrofuran derivative, candidate ALDH2 inhibitor * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Ethyl 5-ethyl-2-[(5-nitrofuran-2-carbonyl)amino]thiophene-3-carboxylate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nicotinamide 1000μM R03 exp101 https://crispr.tyerslab.com/wiki/results/exp101?rev=1767843420&do=diff Nicotinamide 1000μM R03 exp101 Mechanism of Action NAD biosynthetic precursor, activates SIRT1 * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Nicotinamide * Synonyms: Niacinamide; Nicotinic acid amide; Vitamin B3 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nifuroxazide 5μM R03 exp102 https://crispr.tyerslab.com/wiki/results/exp102?rev=1767843420&do=diff Nifuroxazide 5μM R03 exp102 Mechanism of Action Nitrofuran antibiotic * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Nifuroxazide * Synonyms: N/A * CAS #: 965-52-6 * PubChem CID: 5337997 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Taxol 0.004μM R03 exp103 https://crispr.tyerslab.com/wiki/results/exp103?rev=1767843420&do=diff Taxol 0.004μM R03 exp103 Mechanism of Action Inhibits microtubule depolymerisation, blocks metaphase to anaphase transition * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM131593 0.2μM R03 exp106 https://crispr.tyerslab.com/wiki/results/exp106?rev=1767843420&do=diff UM131593 0.2μM R03 exp106 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * IUPAC: N/A * INCHI Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UMK57 0.6μM R03 exp107 https://crispr.tyerslab.com/wiki/results/exp107?rev=1767843420&do=diff UMK57 0.6μM R03 exp107 Mechanism of Action Potentiates kinesin-13 (MCAK), destabilizes kinetochore-MT attachment, suppresses chromosome mis-segregation * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vinblastine 0.2μM R03 exp108 https://crispr.tyerslab.com/wiki/results/exp108?rev=1767843420&do=diff Vinblastine 0.2μM R03 exp108 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) R-DABN 8μM R03 exp111 https://crispr.tyerslab.com/wiki/results/exp111?rev=1767843420&do=diff R-DABN 8μM R03 exp111 Mechanism of Action Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) S-DABN 8μM R03 exp112 https://crispr.tyerslab.com/wiki/results/exp112?rev=1767843420&do=diff S-DABN 8μM R03 exp112 Mechanism of Action Unknown, (S) atropisomer of 1,1'-Binaphthyl-2,2'-diamine * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: [1,1'-Binaphthalene]-2,2'-diamine * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 1-Methyl-nicotinamide-chloride 1000μM R03 exp113 https://crispr.tyerslab.com/wiki/results/exp113?rev=1767843420&do=diff 1-Methyl-nicotinamide-chloride 1000μM R03 exp113 Mechanism of Action Nicotinamde metabolite, generated by nicotinamide N-methyltransferase (NNMT) * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: 3-Carbamyl-1-methylpyridinium chloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) A-196 10μM R03 exp114 https://crispr.tyerslab.com/wiki/results/exp114?rev=1767843420&do=diff A-196 10μM R03 exp114 Mechanism of Action Inhibits SUV420H1 and SUV420H2 inhibitor, blocks di/trimethylation of H4K20me * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) A-366 10μM R03 exp115 https://crispr.tyerslab.com/wiki/results/exp115?rev=1767843420&do=diff A-366 10μM R03 exp115 Mechanism of Action Inhibits G9a/EHMT1, blocks methylation of H3K9 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: CID 76285486 * Synonyms: N/A * CAS #: 1527503-11-2 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) AICAR 240μM R03 exp116 https://crispr.tyerslab.com/wiki/results/exp116?rev=1767843420&do=diff AICAR 240μM R03 exp116 Mechanism of Action Metabolic intermediate in purine biosynthesis, activates AMPK, has other putative targets * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / Kinase Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dimethyl-Sulfoxide 1pc R03 exp120 https://crispr.tyerslab.com/wiki/results/exp120?rev=1767843420&do=diff Dimethyl-Sulfoxide 1pc R03 exp120 Mechanism of Action N/A * Class / Subclass 1: Chemogenomic Negative Control / Solvent Technical Notes * PubChem Name: Dimethyl sulfoxide * Synonyms: N/A * CAS #: 67-68-5 * PubChem CID: 679 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Golgicide-A 2μM R03 exp121 https://crispr.tyerslab.com/wiki/results/exp121?rev=1767843420&do=diff Golgicide-A 2μM R03 exp121 Mechanism of Action Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi * Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor Technical Notes * PubChem Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Golgicide-A 4μM R03 exp122 https://crispr.tyerslab.com/wiki/results/exp122?rev=1767843420&do=diff Golgicide-A 4μM R03 exp122 Mechanism of Action Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi * Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor Technical Notes * PubChem Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK-LSD1 10μM R03 exp123 https://crispr.tyerslab.com/wiki/results/exp123?rev=1767843420&do=diff GSK-LSD1 10μM R03 exp123 Mechanism of Action Inhibits LSD1 histone demethylase (H3K4me/me2, H3K9me) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: GSK-LSD1 Dihydrochloride * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK343 3μM R03 exp124 https://crispr.tyerslab.com/wiki/results/exp124?rev=1767843420&do=diff GSK343 3μM R03 exp124 Mechanism of Action Inhibits EZH1 catalytic subunit of PRC2 histone methyltransferase (H3K27me3) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-propan-2-ylindazole-4-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK461364A 0.005μM R03 exp125 https://crispr.tyerslab.com/wiki/results/exp125?rev=1767843420&do=diff GSK461364A 0.005μM R03 exp125 Mechanism of Action Inhibits PLK1 * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor Technical Notes * PubChem Name: Gsk-461364 * Synonyms: GSK461364A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK461364A 0.1μM R03 exp126 https://crispr.tyerslab.com/wiki/results/exp126?rev=1767843420&do=diff GSK461364A 0.1μM R03 exp126 Mechanism of Action Inhibits PLK1 * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor Technical Notes * PubChem Name: Gsk-461364 * Synonyms: GSK461364A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK591 2.6μM R03 exp128 https://crispr.tyerslab.com/wiki/results/exp128?rev=1767843420&do=diff GSK591 2.6μM R03 exp128 Mechanism of Action Inhibits protein arginine methyltransferase PRMT5, inactive control is SGC2096 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Isonicotinamide 500μM R03 exp129 https://crispr.tyerslab.com/wiki/results/exp129?rev=1767843420&do=diff Isonicotinamide 500μM R03 exp129 Mechanism of Action nicotinamide antagonist, putative SIRT1 activator * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Isonicotinamide * Synonyms: N/A * CAS #: 1453-82-3 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) JQ1 0.01μM R03 exp130 https://crispr.tyerslab.com/wiki/results/exp130?rev=1767843420&do=diff JQ1 0.01μM R03 exp130 Mechanism of Action Inhibits BET bromodomain proteins BRD2, BRD3, BRD4, BRDT * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: JQ1 compound * Synonyms: JQ1 * CAS #: 1268524-70-4 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) L-74142 5μM R03 exp131 https://crispr.tyerslab.com/wiki/results/exp131?rev=1767843420&do=diff L-74142 5μM R03 exp131 Mechanism of Action DRD4 receptor antagonist * Class / Subclass 1: Signal Transduction / GPCR antagonist Technical Notes * PubChem Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-YL)isoxazole hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Metformin 40μM R03 exp132 https://crispr.tyerslab.com/wiki/results/exp132?rev=1767843420&do=diff Metformin 40μM R03 exp132 Mechanism of Action Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MKC9989 10μM R03 exp133 https://crispr.tyerslab.com/wiki/results/exp133?rev=1767843420&do=diff MKC9989 10μM R03 exp133 Mechanism of Action Inhibits IRE1, prevents ER unfolded protein response * Class / Subclass 1: Proteostasis / Unfolded Protein Response Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MS023 2μM R03 exp134 https://crispr.tyerslab.com/wiki/results/exp134?rev=1767843420&do=diff MS023 2μM R03 exp134 Mechanism of Action Inhibits protein arginine N-methyltransferase PRMT1 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: MS023 (dihydrochloride) * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MS023 7μM R03 exp135 https://crispr.tyerslab.com/wiki/results/exp135?rev=1767843420&do=diff MS023 7μM R03 exp135 Mechanism of Action Inhibits protein arginine N-methyltransferase PRMT1 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: MS023 (dihydrochloride) * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MS094 2μM R03 exp136 https://crispr.tyerslab.com/wiki/results/exp136?rev=1767843420&do=diff MS094 2μM R03 exp136 Mechanism of Action Inactive control for MS023 PRMT1 inhibitor * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: 1831110-55-4 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nicotinamide Riboside 100μM R03 exp139 https://crispr.tyerslab.com/wiki/results/exp139?rev=1767843420&do=diff Nicotinamide Riboside 100μM R03 exp139 Mechanism of Action NAD precursor, activates SIRT1 * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Nicotinamide riboside chloride * Synonyms: N/A * CAS #: 23111-00-4 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nicotinate 1000μM R03 exp140 https://crispr.tyerslab.com/wiki/results/exp140?rev=1767843420&do=diff Nicotinate 1000μM R03 exp140 Mechanism of Action NAD precursor (a.k.a. niacin, vitamin B3) * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Nicotinic acid * Synonyms: Nicotinic acid; Vitamin B3 * CAS #: 59-67-6 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nifurtimox 1μM R03 exp141 https://crispr.tyerslab.com/wiki/results/exp141?rev=1767843420&do=diff Nifurtimox 1μM R03 exp141 Mechanism of Action Nitrofuran derivative, forms nitro-anion radical metabolite, induces ROS * Class / Subclass 1: Infectious Disease / Antitrypanosomal Technical Notes * PubChem Name: Nifurtimox * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) OICR-9429 10μM R03 exp142 https://crispr.tyerslab.com/wiki/results/exp142?rev=1767843420&do=diff OICR-9429 10μM R03 exp142 Mechanism of Action Inhibits interaction between WDR5 and MLL1 (KMT2A) in MLL H3K4 trimethylase complex * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Phenformin 20μM R03 exp143 https://crispr.tyerslab.com/wiki/results/exp143?rev=1767843420&do=diff Phenformin 20μM R03 exp143 Mechanism of Action Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor * Class / Subclass 2: Metabolism / Metabolic Enzyme Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PFI-3 10μM R03 exp144 https://crispr.tyerslab.com/wiki/results/exp144?rev=1767843420&do=diff PFI-3 10μM R03 exp144 Mechanism of Action Inhibits SMARCA2/4 and PB1 bromodomain proteins, components of SNF/SWI chromatin remodelling complex * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: (E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-pyridin-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PNU96415E 10μM R03 exp145 https://crispr.tyerslab.com/wiki/results/exp145?rev=1767843420&do=diff PNU96415E 10μM R03 exp145 Mechanism of Action Antagonist of DRD4 and 5-HT2A receptors * Class / Subclass 1: Signal Transduction / GPCR Antagonist Technical Notes * PubChem Name: 1-(4-Fluorophenyl)-4-(2-(isochroman-1-yl)ethyl)piperazine dihydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Quinacrine 2.5μM R03 exp146 https://crispr.tyerslab.com/wiki/results/exp146?rev=1767843420&do=diff Quinacrine 2.5μM R03 exp146 Mechanism of Action Intercalates into DNA and RNA, interferes with transcription and translation * Class / Subclass 1: Infectious Disease / Antimalarial * Class / Subclass 2: DNA Damage, Repair and Replication / Intercalating Agent text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Resveratrol 16μM R03 exp147 https://crispr.tyerslab.com/wiki/results/exp147?rev=1767843420&do=diff Resveratrol 16μM R03 exp147 Mechanism of Action Putative sirtuin activator, many other ascribed activities, analog of pterostilbene * Class / Subclass 1: Gene Regulation / Epigenetic Activator Technical Notes * PubChem Name: Resveratrol * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SB202190 10μM R03 exp148 https://crispr.tyerslab.com/wiki/results/exp148?rev=1767843420&do=diff SB202190 10μM R03 exp148 Mechanism of Action Inhibits p38‘± (MAPK14)and p38‘_ (MAPK11) kinase, ATP competitive * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SB203580 25μM R03 exp149 https://crispr.tyerslab.com/wiki/results/exp149?rev=1767843420&do=diff SB203580 25μM R03 exp149 Mechanism of Action p38 MAP kinase inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Proteostasis / Autophagy Inhibitor Technical Notes * PubChem Name: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SGC0649 7μM R03 exp150 https://crispr.tyerslab.com/wiki/results/exp150?rev=1767843420&do=diff SGC0649 7μM R03 exp150 Mechanism of Action Inactive control for SGC0649 (DOT1L methyltransferase inhibitor) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SGC0946 7μM R03 exp151 https://crispr.tyerslab.com/wiki/results/exp151?rev=1767843420&do=diff SGC0946 7μM R03 exp151 Mechanism of Action DOT1L methyltransferase inhibitor * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: 1-[3-[[(2R,3S,4R,5R)-5-(4-Amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SGC2043 10μM R03 exp152 https://crispr.tyerslab.com/wiki/results/exp152?rev=1767843420&do=diff SGC2043 10μM R03 exp152 Mechanism of Action Inactive control for A-196 (SUV420H1/H2 inhibitor) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SGC2096 2.6μM R03 exp153 https://crispr.tyerslab.com/wiki/results/exp153?rev=1767843420&do=diff SGC2096 2.6μM R03 exp153 Mechanism of Action Inactive control for GSK591 (PRMT5 inhibitor) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UNC1999 2μM R03 exp155 https://crispr.tyerslab.com/wiki/results/exp155?rev=1767843420&do=diff UNC1999 2μM R03 exp155 Mechanism of Action Inhibits EZH2 catalytic subunit of PRC2 histone methyltransferase (H3K27me3) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UNC2400 2μM R03 exp156 https://crispr.tyerslab.com/wiki/results/exp156?rev=1767843420&do=diff UNC2400 2μM R03 exp156 Mechanism of Action Inactive control for UNC1999 (EZH2 inhibitor) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N-[(1,6-Dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Docetaxel 0.001 to 0.002μM on day4 R04 exp159 https://crispr.tyerslab.com/wiki/results/exp159?rev=1767843420&do=diff Docetaxel 0.001 to 0.002μM on day4 R04 exp159 Mechanism of Action Inihibts microtubule depolymerization, semi-synthetic analog of the paclitaxel * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ribavirin 10 to 15μM on day4 R04 exp160 https://crispr.tyerslab.com/wiki/results/exp160?rev=1767843420&do=diff Ribavirin 10 to 15μM on day4 R04 exp160 Mechanism of Action Prodrug metabolized to purine RNA nucleotide mimetic, also inhibits EIF4E * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: Metabolism / Antimetabolite * Class / Subclass 3: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BI-D1870 2μM R04 exp162 https://crispr.tyerslab.com/wiki/results/exp162?rev=1767843420&do=diff BI-D1870 2μM R04 exp162 Mechanism of Action Inhibits ribosomal p90 S6 Kinase, active against RSK1/2/3/4 isoforms * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 2-((3,5-Difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Q15 1 to 2μM on day4 R04 exp164 https://crispr.tyerslab.com/wiki/results/exp164?rev=1767843420&do=diff Q15 1 to 2μM on day4 R04 exp164 Mechanism of Action Putative condensin inhibitor * Class / Subclass 1: Cell Cycle / Chromosome Dynamics Inhibitor Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: 1071780-64-7 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) RO-3306 3 to 4μM on day4 R04 exp165 https://crispr.tyerslab.com/wiki/results/exp165?rev=1767843420&do=diff RO-3306 3 to 4μM on day4 R04 exp165 Mechanism of Action Inhibits CDK1, ATP-competitive, causes G2/M arrest * Class / Subclass 1: Cell Cycle / Kinase Inhibitor Technical Notes * PubChem Name: (5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BH1 1μM R04 exp169 https://crispr.tyerslab.com/wiki/results/exp169?rev=1767843420&do=diff BH1 1μM R04 exp169 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 4-Amino-N-[4-[5-[(4-aminobenzoyl)amino]-4-chloro-1H-benzimidazol-2-yl]-2-chlorophenyl]benzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Metformin 100 to 150μM on day4 R04 exp170 https://crispr.tyerslab.com/wiki/results/exp170?rev=1767843420&do=diff Metformin 100 to 150μM on day4 R04 exp170 Mechanism of Action Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 3-Bromopyruvate 7μM R04 exp175 https://crispr.tyerslab.com/wiki/results/exp175?rev=1767843420&do=diff 3-Bromopyruvate 7μM R04 exp175 Mechanism of Action Inhibits hexokinase II, pyruvate analog, enzyme alkylator, blocks glycolysis * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Bromopyruvic acid text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Apcin 50 to 100μM on day4 R04 exp176 https://crispr.tyerslab.com/wiki/results/exp176?rev=1767843420&do=diff Apcin 50 to 100μM on day4 R04 exp176 Mechanism of Action Inhibits substrate interactions with APC/C-Cdc20 * Class / Subclass 1: Proteostasis / E3 ubiquitin ligase inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Apcin 25μM plus proTAME 2μM R04 exp177 https://crispr.tyerslab.com/wiki/results/exp177?rev=1767843420&do=diff Apcin 25μM plus proTAME 2μM R04 exp177 Mechanism of Action Inhibits substrate interactions with APC/C-Cdc20 * Class / Subclass 1: Proteostasis / E3 ubiquitin ligase inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 https://crispr.tyerslab.com/wiki/results/exp179?rev=1767843420&do=diff Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 Mechanism of Action Inhibits microtubule polymerization * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dynasore 10μM R04 exp180 https://crispr.tyerslab.com/wiki/results/exp180?rev=1767843420&do=diff Dynasore 10μM R04 exp180 Mechanism of Action Putative dynamin GTPase inhibitor, blocks endocytosis * Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor Technical Notes * PubChem Name: Dynasore * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) IU1-47 25μM R04 exp182 https://crispr.tyerslab.com/wiki/results/exp182?rev=1767843420&do=diff IU1-47 25μM R04 exp182 Mechanism of Action Inhibits USP14, enhances protein degradation by 26S proteasome * Class / Subclass 1: Proteostasis / Deubiquitinase (DUB) Inhibitor Technical Notes * PubChem Name: 1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) IU1-C 25μM R04 exp183 https://crispr.tyerslab.com/wiki/results/exp183?rev=1767843420&do=diff IU1-C 25μM R04 exp183 Mechanism of Action Inactive analog of IU1-47 * Class / Subclass 1: Proteostasis / Ubiquitin-Proteasome Inhibitor Technical Notes * PubChem Name: [1-(4-Fluorophenyl)-2,5-dimethylpyrrol-3-yl]-(4-methylpiperidin-1-yl)methanone text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 https://crispr.tyerslab.com/wiki/results/exp184?rev=1767843420&do=diff Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 Mechanism of Action Inhibits microtubule depolymerization, semi-synthetic analog of epothilone * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) L-BMAA 500 to 750μM on day4 R04 exp185 https://crispr.tyerslab.com/wiki/results/exp185?rev=1767843420&do=diff L-BMAA 500 to 750μM on day4 R04 exp185 Mechanism of Action ‘_-Methylamino-l-alanine, cyanobacterial neurotoxin, possible causative agent of ALS * Class / Subclass 1: Environmental Stresses / Toxin Technical Notes * PubChem Name: (S)-2-Amino-3-(methylamino)propanoic acid hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) proTAME 5μM R04 exp187 https://crispr.tyerslab.com/wiki/results/exp187?rev=1767843420&do=diff proTAME 5μM R04 exp187 Mechanism of Action Inhibits APC/C interaction with Cdc20/Cdh1 substrate recognition cofactors * Class / Subclass 1: Proteostasis / E3 ubiquitin ligase inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Temozolomide 200μM R04 exp189 https://crispr.tyerslab.com/wiki/results/exp189?rev=1767843420&do=diff Temozolomide 200μM R04 exp189 Mechanism of Action Alkylates purine bases, prodrug hydrolyzes to 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) * Class / Subclass 1: DNA Damage, Repair and Replication / Base Alkylation Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vincristine 0.0005μM R04 exp190 https://crispr.tyerslab.com/wiki/results/exp190?rev=1767843420&do=diff Vincristine 0.0005μM R04 exp190 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hypoxia 5%O2 R04 exp191 https://crispr.tyerslab.com/wiki/results/exp191?rev=1767843420&do=diff Hypoxia 5%O2 R04 exp191 Mechanism of Action Reduced growth oxygen * Class / Subclass 1: Environmental Stresses / Stress Condition Screen Summary * Round: 04 * Dose: N/A * Days of incubation: 12 * Doublings: N/A * Numbers of reads text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Etoposide 0.1μM R05 exp198 https://crispr.tyerslab.com/wiki/results/exp198?rev=1767843420&do=diff Etoposide 0.1μM R05 exp198 Mechanism of Action Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin * Class / Subclass 1: DNA Damage, Repair and Replication / Topoisomerase II Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Etoposide 0.3μM R05 exp199 https://crispr.tyerslab.com/wiki/results/exp199?rev=1767843420&do=diff Etoposide 0.3μM R05 exp199 Mechanism of Action Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin * Class / Subclass 1: DNA Damage, Repair and Replication / Topoisomerase II Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vinblastine 0.015μM R05 exp208 https://crispr.tyerslab.com/wiki/results/exp208?rev=1767843420&do=diff Vinblastine 0.015μM R05 exp208 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Deguelin 0.15μM R05 exp209 https://crispr.tyerslab.com/wiki/results/exp209?rev=1767843420&do=diff Deguelin 0.15μM R05 exp209 Mechanism of Action Derivative of rotenone, putative AKT inhibitor, complex I inhibitor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LB-100 2μM R05 exp210 https://crispr.tyerslab.com/wiki/results/exp210?rev=1767843420&do=diff LB-100 2μM R05 exp210 Mechanism of Action Inhibits protein phosphatase 2A * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: LB-100 * Synonyms: N/A * CAS #: 1026680-07-8 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) AICAR 240μM R05 exp211 https://crispr.tyerslab.com/wiki/results/exp211?rev=1767843420&do=diff AICAR 240μM R05 exp211 Mechanism of Action Metabolic intermediate in purine biosynthesis, activates AMPK, has other putative targets * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / Kinase Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Phenformin 20μM R05 exp212 https://crispr.tyerslab.com/wiki/results/exp212?rev=1767843420&do=diff Phenformin 20μM R05 exp212 Mechanism of Action Inhibits mitochondrial respiratory chain complex I, indirectly activates AMPK * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor * Class / Subclass 2: Metabolism / Metabolic Enzyme Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 2-Deoxy-D-glucose 800μM R05 exp214 https://crispr.tyerslab.com/wiki/results/exp214?rev=1767843420&do=diff 2-Deoxy-D-glucose 800μM R05 exp214 Mechanism of Action Inhibits phosphoglucoisomerase, competitive, blocks glycolysis * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Deoxyglucose * Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Colchicine 0.009μM R05 exp215 https://crispr.tyerslab.com/wiki/results/exp215?rev=1767843420&do=diff Colchicine 0.009μM R05 exp215 Mechanism of Action Inhibits microtubule polymerization * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Erlotinib 10μM R05 exp216 https://crispr.tyerslab.com/wiki/results/exp216?rev=1767843420&do=diff Erlotinib 10μM R05 exp216 Mechanism of Action Inhibits EGFR, also cyclin G-associated kinase (GAK) * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Erlotinib * Synonyms: CP-358774; NSC 718781; OSI-774 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Mdivi-1 15μM R05 exp217 https://crispr.tyerslab.com/wiki/results/exp217?rev=1767843420&do=diff Mdivi-1 15μM R05 exp217 Mechanism of Action Inhibits GTPase dynamin-related protein 1 (Drp1), impairs mitochondrial fission, also inhibits respiratory complex I * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) A-395 10μM R05 exp218 https://crispr.tyerslab.com/wiki/results/exp218?rev=1767843420&do=diff A-395 10μM R05 exp218 Mechanism of Action Inhibits EED subunit of PRC2 complex, blocks H3K27me3 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]pyrrolidin-3-amine text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) A-395N 10μM R05 exp219 https://crispr.tyerslab.com/wiki/results/exp219?rev=1767843420&do=diff A-395N 10μM R05 exp219 Mechanism of Action Inactive analog of A-395 EED inhibitor * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: (3S,4R)-1-Benzyl-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BAY-598 4μM R05 exp220 https://crispr.tyerslab.com/wiki/results/exp220?rev=1767843420&do=diff BAY-598 4μM R05 exp220 Mechanism of Action Inhibits SMYD2 lysine methyltransferase that acts on H3K4me, H3K36me, p53 and other substrates * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N-[(4S)-2-[N-Cyano-N'-[3-(difluoromethoxy)phenyl]carbamimidoyl]-5-(3,4-dichlorophenyl)-3,4-dihydropyrazol-4-yl]-N-ethyl-2-hydroxyacetamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Betulinic acid 10 to 15μM on day4 R05 exp222 https://crispr.tyerslab.com/wiki/results/exp222?rev=1767843420&do=diff Betulinic acid 10 to 15μM on day4 R05 exp222 Mechanism of Action Pentacyclic triterpenoid, claimed antiretroviral, antimalarial, anti-inflammatory, topoisomerase I/II inhibitor * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cabazitaxel 0.001μM R05 exp223 https://crispr.tyerslab.com/wiki/results/exp223?rev=1767843420&do=diff Cabazitaxel 0.001μM R05 exp223 Mechanism of Action Microtubule stabilizer, semi-synthetic taxane * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CB-839 10μM R05 exp224 https://crispr.tyerslab.com/wiki/results/exp224?rev=1767843420&do=diff CB-839 10μM R05 exp224 Mechanism of Action Inhibits glutaminase (GLS1), reversible * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: CB-839 * Synonyms: CB-839 * CAS #: 1439399-58-2 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Celastrol 0.12μM R05 exp225 https://crispr.tyerslab.com/wiki/results/exp225?rev=1767843420&do=diff Celastrol 0.12μM R05 exp225 Mechanism of Action Putative antioxidant, anti-inflammatory, antiobesity anticancer, proteasome inhibitor * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Proteostasis / Ubiquitin-Proteasome Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cerivastatin 0.15μM R05 exp226 https://crispr.tyerslab.com/wiki/results/exp226?rev=1767843420&do=diff Cerivastatin 0.15μM R05 exp226 Mechanism of Action Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL receptors * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Cerivastatin sodium text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cryptotanshinone 12μM R05 exp227 https://crispr.tyerslab.com/wiki/results/exp227?rev=1767843420&do=diff Cryptotanshinone 12μM R05 exp227 Mechanism of Action Putative acetylcholinesterase and STAT3 inhibitor * Class / Subclass 1: Uncharacterized Mechanism / Natural Product Technical Notes * PubChem Name: Cryptotanshinone * Synonyms: Cryptotanshinon; Tanshinone c text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Demecolcine 0.03μM R05 exp228 https://crispr.tyerslab.com/wiki/results/exp228?rev=1767843420&do=diff Demecolcine 0.03μM R05 exp228 Mechanism of Action Inhibits microtubule polymerization, a.k.a. colcemid * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dimethyloxaloylglycine 100μM R05 exp229 https://crispr.tyerslab.com/wiki/results/exp229?rev=1767843420&do=diff Dimethyloxaloylglycine 100μM R05 exp229 Mechanism of Action Prolylhydroxylase inhibitor, induces HIF-1α accumulation * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor * Class / Subclass 2: Signal Transduction / Other inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Epigallocatechin gallate 20μM R05 exp230 https://crispr.tyerslab.com/wiki/results/exp230?rev=1767843420&do=diff Epigallocatechin gallate 20μM R05 exp230 Mechanism of Action Polyphenol antioxidant from green tea, numerous claimed activities * Class / Subclass 1: Metabolism / Nutraceutical * Class / Subclass 2: Environmental Stresses / Food Additive Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Epothilone-B 0.0015μM R05 exp231 https://crispr.tyerslab.com/wiki/results/exp231?rev=1767843420&do=diff Epothilone-B 0.0015μM R05 exp231 Mechanism of Action Inhibits microtubule depolymerization, parent compound of ixabepilone * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 https://crispr.tyerslab.com/wiki/results/exp232?rev=1767843420&do=diff Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 Mechanism of Action Microtubule stabilizer * Class / Subclass 1: Organelle Function / Cytoskeletal Inhibitor * Class / Subclass 2: Cell Cycle / Microtubule Poison Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) EPZ-5676 30μM R05 exp233 https://crispr.tyerslab.com/wiki/results/exp233?rev=1767843420&do=diff EPZ-5676 30μM R05 exp233 Mechanism of Action Inhibits DOT1L lysine methyltransferase (H3K79me2) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Pinometostat * Synonyms: EPZ-5676 * CAS #: 1380288-87-8 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ethanol 0.01 R05 exp234 https://crispr.tyerslab.com/wiki/results/exp234?rev=1767843420&do=diff Ethanol 0.01 R05 exp234 Mechanism of Action Pleiotropic effects on membranes, ion channels, enzymes, receptors * Class / Subclass 1: Environmental Stresses / Solvent Technical Notes * PubChem Name: Ethanol * Synonyms: N/A * CAS #: 64-17-5 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Geldanamycin 0.01μM R05 exp235 https://crispr.tyerslab.com/wiki/results/exp235?rev=1767843420&do=diff Geldanamycin 0.01μM R05 exp235 Mechanism of Action HSP90 inhibitor * Class / Subclass 1: Proteostasis / Chaperone Inhibitor Technical Notes * PubChem Name: Geldanamycin * Synonyms: N/A * CAS #: 30562-34-6 * PubChem CID: 5288382 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK2606414 1μM R05 exp236 https://crispr.tyerslab.com/wiki/results/exp236?rev=1767843420&do=diff GSK2606414 1μM R05 exp236 Mechanism of Action Inhibits PERK, also KIT receptor * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: CID 53469448 * Synonyms: N/A * CAS #: 1337531-36-8 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NN-Diethyl-meta-toluamide 100μM R05 exp237 https://crispr.tyerslab.com/wiki/results/exp237?rev=1767843420&do=diff NN-Diethyl-meta-toluamide 100μM R05 exp237 Mechanism of Action Insect repellent * Class / Subclass 1: Environmental Stresses / Environmental Contaminant Technical Notes * PubChem Name: N,N-Diethyl-3-methylbenzamide * Synonyms: DEET; N,N-Diethyl-m-toluamide; DEET;N,N-Diethyl-m-toluamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Parthenolide 2.5μM R05 exp238 https://crispr.tyerslab.com/wiki/results/exp238?rev=1767843420&do=diff Parthenolide 2.5μM R05 exp238 Mechanism of Action Sesquiterpene lactone with attributed activities in microtubule function, NF-κB activation, HDAC1 inhibition, MDM2 ubiquitination. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PFI-2 4μM R05 exp239 https://crispr.tyerslab.com/wiki/results/exp239?rev=1767843420&do=diff PFI-2 4μM R05 exp239 Mechanism of Action Inhibits SETD7 lysine methyltransferase (H3K4me) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: 8-Fluoro-N-[(2S)-1-oxo-1-pyrrolidin-1-yl-3-[3-(trifluoromethyl)phenyl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide;hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pyridostatin 4μM R05 exp240 https://crispr.tyerslab.com/wiki/results/exp240?rev=1767843420&do=diff Pyridostatin 4μM R05 exp240 Mechanism of Action Binds and stabilizes telomeric and interstitial G-quadruplexes * Class / Subclass 1: DNA Damage, Repair and Replication / G-Quadruplex Stabilizer Technical Notes * PubChem Name: Pyridostatin * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) QNZ 0.01μM R05 exp241 https://crispr.tyerslab.com/wiki/results/exp241?rev=1767843420&do=diff QNZ 0.01μM R05 exp241 Mechanism of Action Inhibits NF-κB activation, TNF-α production * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Apoptosis Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Radicicol 0.16μM R05 exp242 https://crispr.tyerslab.com/wiki/results/exp242?rev=1767843420&do=diff Radicicol 0.16μM R05 exp242 Mechanism of Action Inhibits HSP90 * Class / Subclass 1: Proteostasis / Chaperone Inhibitor * Class / Subclass 2: Infectious Disease / Antifungal Technical Notes * PubChem Name: Radicicol * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) S-trityl-L-cysteine 0.5μM R05 exp243 https://crispr.tyerslab.com/wiki/results/exp243?rev=1767843420&do=diff S-trityl-L-cysteine 0.5μM R05 exp243 Mechanism of Action Inhibits Eg5 kinesin, blocks centrosome separation and bipolar spindle formation, arrests cells with monoastral spindles * Class / Subclass 1: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SB743921 0.001μM R05 exp244 https://crispr.tyerslab.com/wiki/results/exp244?rev=1767843420&do=diff SB743921 0.001μM R05 exp244 Mechanism of Action Inhibits Eg5 kinesin, derivative of S-trityl-L-cysteine * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor Technical Notes * PubChem Name: N-(3-Aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide;hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0011500 5μM R05 exp245 https://crispr.tyerslab.com/wiki/results/exp245?rev=1767843420&do=diff UM0011500 5μM R05 exp245 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 3-(5,6-Dimethyl-1,3-dihydroisoindol-2-yl)-N-[(Z)-furan-2-ylmethylideneamino]benzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0011500 10μM R05 exp246 https://crispr.tyerslab.com/wiki/results/exp246?rev=1767843420&do=diff UM0011500 10μM R05 exp246 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 3-(5,6-Dimethyl-1,3-dihydroisoindol-2-yl)-N-[(Z)-furan-2-ylmethylideneamino]benzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0130462 0.025 to 0.035μM day4 R05 exp247 https://crispr.tyerslab.com/wiki/results/exp247?rev=1767843420&do=diff UM0130462 0.025 to 0.035μM day4 R05 exp247 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 1-Chloro-2-(2-chloroethyl)-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) UM0131023 0.05μM R05 exp248 https://crispr.tyerslab.com/wiki/results/exp248?rev=1767843420&do=diff UM0131023 0.05μM R05 exp248 Mechanism of Action Unknown * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * IUPAC: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vinorelbine 0.001μM R05 exp249 https://crispr.tyerslab.com/wiki/results/exp249?rev=1767843420&do=diff Vinorelbine 0.001μM R05 exp249 Mechanism of Action Inhibits microtubule polymerization and mitotic spindle formation, induces spindle assembly checkpoint (SAC) * Class / Subclass 1: Cell Cycle / Microtubule Poison * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) HMS-I1 10μM R06 exp256 https://crispr.tyerslab.com/wiki/results/exp256?rev=1767843420&do=diff HMS-I1 10μM R06 exp256 Mechanism of Action Inhibits HDAC * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-6-methylimidazo[1,2-a]pyridine * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 6-Thio-2-deoxyguanosine 2μM R06 exp259 https://crispr.tyerslab.com/wiki/results/exp259?rev=1767843420&do=diff 6-Thio-2-deoxyguanosine 2μM R06 exp259 Mechanism of Action Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 0.1μM R06 exp260 https://crispr.tyerslab.com/wiki/results/exp260?rev=1767843420&do=diff ABT-702 0.1μM R06 exp260 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Adenosine Kinase Inhibitor * Synonyms: N/A * CAS #: 1188890-28-9 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 5μM R06 exp261 https://crispr.tyerslab.com/wiki/results/exp261?rev=1767843420&do=diff ABT-702 5μM R06 exp261 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Adenosine Kinase Inhibitor * Synonyms: N/A * CAS #: 1188890-28-9 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Alda-1 10μM R06 exp262 https://crispr.tyerslab.com/wiki/results/exp262?rev=1767843420&do=diff Alda-1 10μM R06 exp262 Mechanism of Action Activates mitochondrial aldehyde dehydrogenase (ALDH2), may attenuate ethanol addiction * Class / Subclass 1: Metabolism / Metabolic Enzyme Activator Technical Notes * PubChem Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Aphidicolin 0.04μM R06 exp263 https://crispr.tyerslab.com/wiki/results/exp263?rev=1767843420&do=diff Aphidicolin 0.04μM R06 exp263 Mechanism of Action Inhibits DNA polymerases Polα, Polδ, Polϵ and Polζ * Class / Subclass 1: DNA Damage, Repair and Replication / Replication Inhibitor * Class / Subclass 2: Cell Cycle / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Arsenate 40μM R06 exp264 https://crispr.tyerslab.com/wiki/results/exp264?rev=1767843420&do=diff Arsenate 40μM R06 exp264 Mechanism of Action Heavy metal toxin, environmental contaminant * Class / Subclass 1: Environmental Stresses / Heavy Metal Technical Notes * PubChem Name: Sodium arsenate heptahydrate * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bisphenol A 100μM R06 exp269 https://crispr.tyerslab.com/wiki/results/exp269?rev=1767843420&do=diff Bisphenol A 100μM R06 exp269 Mechanism of Action Widely-used in plastics and epoxy resins, endocrine disrupter * Class / Subclass 1: Environmental Stresses / Industrial Chemical Technical Notes * PubChem Name: Bisphenol A * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Campthothecin 0.001μM R06 exp270 https://crispr.tyerslab.com/wiki/results/exp270?rev=1767843420&do=diff Campthothecin 0.001μM R06 exp270 Mechanism of Action Inhibits topoisomerase I, stabilizes TopoI-DNA complex, causes DNA strand breaks * Class / Subclass 1: DNA Damage, Repair and Replication / Clastogen Technical Notes * PubChem Name: Camptothecin text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CCT251545 0.2μM R06 exp271 https://crispr.tyerslab.com/wiki/results/exp271?rev=1767843420&do=diff CCT251545 0.2μM R06 exp271 Mechanism of Action Inhibits CDK8 and CDK19 mediator-associated kinases * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CHIR-124 0.04μM R06 exp272 https://crispr.tyerslab.com/wiki/results/exp272?rev=1767843420&do=diff CHIR-124 0.04μM R06 exp272 Mechanism of Action Inhibits CHK1, blocks checkpoint arrest, potentiates DNA damaging agents * Class / Subclass 1: DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cisplatin 0.35μM R06 exp273 https://crispr.tyerslab.com/wiki/results/exp273?rev=1767843420&do=diff Cisplatin 0.35μM R06 exp273 Mechanism of Action Intrastrand cross-linker * Class / Subclass 1: DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker Technical Notes * PubChem Name: Cisplatin * Synonyms: CDDP; cis-Diaminodichloroplatinum text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Citral 50μM R06 exp274 https://crispr.tyerslab.com/wiki/results/exp274?rev=1767843420&do=diff Citral 50μM R06 exp274 Mechanism of Action putative ALDH inhibitor, essential oil * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Citral 75μM R06 exp275 https://crispr.tyerslab.com/wiki/results/exp275?rev=1767843420&do=diff Citral 75μM R06 exp275 Mechanism of Action putative ALDH inhibitor, essential oil * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Curcumin 6.5μM R06 exp277 https://crispr.tyerslab.com/wiki/results/exp277?rev=1767843420&do=diff Curcumin 6.5μM R06 exp277 Mechanism of Action Component of tumeric spice, many claimed activities but viewed as pan-assay interference compound * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Metabolism / Nutraceutical text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CVT-10216 0.1μM R06 exp278 https://crispr.tyerslab.com/wiki/results/exp278?rev=1767843420&do=diff CVT-10216 0.1μM R06 exp278 Mechanism of Action Inhibits mitochondrial aldehyde dehydrogenase (ALDH2), main enzyme for oxidative alcohol metabolism * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) D-Fructose 10000μM R06 exp279 https://crispr.tyerslab.com/wiki/results/exp279?rev=1767843420&do=diff D-Fructose 10000μM R06 exp279 Mechanism of Action Monosaccharide * Class / Subclass 1: Metabolism / Nutrient Technical Notes * PubChem Name: D-(-)-Fructose * Synonyms: D(-?)?-?Fructose * CAS #: 57-48-7 * PubChem CID: 5984 * IUPAC: (3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Daidzin 10μM R06 exp280 https://crispr.tyerslab.com/wiki/results/exp280?rev=1767843420&do=diff Daidzin 10μM R06 exp280 Mechanism of Action Isoflavone from soy bean, putative ALDH inhibitor * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Disulfiram 4.3μM R06 exp281 https://crispr.tyerslab.com/wiki/results/exp281?rev=1767843420&do=diff Disulfiram 4.3μM R06 exp281 Mechanism of Action ALDH1 inhibitor, putative 26S proteasome inhibitor * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor * Class / Subclass 2: Proteostasis / Ubiquitin-Proteasome Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Fluvastatin 2.2μM R06 exp282 https://crispr.tyerslab.com/wiki/results/exp282?rev=1767843420&do=diff Fluvastatin 2.2μM R06 exp282 Mechanism of Action Inhibits HMG-CoA reductase, decreases cholesterol biogenesis, upregulates LDL-receptors * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Fluvastatin sodium text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Glyphosate 1000μM R06 exp283 https://crispr.tyerslab.com/wiki/results/exp283?rev=1767843420&do=diff Glyphosate 1000μM R06 exp283 Mechanism of Action Inhibits 5-enolpyruvylshikimate-3-phosphate synthase, a.k.a Roundup * Class / Subclass 1: Environmental Stresses / Herbicide Technical Notes * PubChem Name: Glyphosate * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GW501516 25μM R06 exp285 https://crispr.tyerslab.com/wiki/results/exp285?rev=1767843420&do=diff GW501516 25μM R06 exp285 Mechanism of Action PPARδ receptor agonist, increases metabolism, banned performance enhancer * Class / Subclass 1: Gene Regulation / Nuclear Receptor Ligand * Class / Subclass 2: Metabolism / Hormone Agonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) HMS-I2 1μM R06 exp286 https://crispr.tyerslab.com/wiki/results/exp286?rev=1767843420&do=diff HMS-I2 1μM R06 exp286 Mechanism of Action putative HDAC inhibitor from cell-based screen * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N-(1-Benzothiophen-2-yl)-4-[(2-chloro-6-fluorophenyl)methyl]piperazine-1-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) HMS-I2 5μM R06 exp287 https://crispr.tyerslab.com/wiki/results/exp287?rev=1767843420&do=diff HMS-I2 5μM R06 exp287 Mechanism of Action putative HDAC inhibitor from cell-based screen * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N-(1-Benzothiophen-2-yl)-4-[(2-chloro-6-fluorophenyl)methyl]piperazine-1-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) HMS-I2 10μM R06 exp288 https://crispr.tyerslab.com/wiki/results/exp288?rev=1767843420&do=diff HMS-I2 10μM R06 exp288 Mechanism of Action putative HDAC inhibitor from cell-based screen * Class / Subclass 1: Uncharacterized Mechanism / Chemical Screen Hit Technical Notes * PubChem Name: N-(1-Benzothiophen-2-yl)-4-[(2-chloro-6-fluorophenyl)methyl]piperazine-1-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hydroxyurea 15μM R06 exp289 https://crispr.tyerslab.com/wiki/results/exp289?rev=1767843420&do=diff Hydroxyurea 15μM R06 exp289 Mechanism of Action Inhibits ribonucleotide reductase, scavenges tyrosyl radicals * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LLY-283 2.6μM R06 exp290 https://crispr.tyerslab.com/wiki/results/exp290?rev=1767843420&do=diff LLY-283 2.6μM R06 exp290 Mechanism of Action Inhibits protein arginine methyltransferase PRMT5, inactive control is LLY-284 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LLY-284 2.6μM R06 exp291 https://crispr.tyerslab.com/wiki/results/exp291?rev=1767843420&do=diff LLY-284 2.6μM R06 exp291 Mechanism of Action Inactive control for LLY-283 PRMT5 inhibitor * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(S)-hydroxy(phenyl)methyl]oxolane-3,4-diol text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Menadione 5μM R06 exp292 https://crispr.tyerslab.com/wiki/results/exp292?rev=1767843420&do=diff Menadione 5μM R06 exp292 Mechanism of Action Synthetic analog of vitamin K, quinone redox cycle generates ROS * Class / Subclass 1: Metabolism / Nutrient * Class / Subclass 2: Environmental Stresses / Food Additive Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Myriocin 25μM R06 exp293 https://crispr.tyerslab.com/wiki/results/exp293?rev=1767843420&do=diff Myriocin 25μM R06 exp293 Mechanism of Action Inhibits serine palmitoyltransferase (SPT1), sphingolipid biosynthesis * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nutlin-3A 1.6μM R06 exp294 https://crispr.tyerslab.com/wiki/results/exp294?rev=1767843420&do=diff Nutlin-3A 1.6μM R06 exp294 Mechanism of Action Inhibits p53-MDM2 interaction * Class / Subclass 1: Proteostasis / E3 ubiquitin ligase inhibitor * Class / Subclass 2: Signal Transduction / Apoptosis Activator Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pyronaridine 1μM R06 exp295 https://crispr.tyerslab.com/wiki/results/exp295?rev=1767843420&do=diff Pyronaridine 1μM R06 exp295 Mechanism of Action Prevents sequestration of heme into hemozoin, forms toxic complex with heme, enhances hematin-induced red blood cell lysis, also intercalates into DNA * Class / Subclass 1: Infectious Disease / Antimalarial text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Sucrose 20000μM R06 exp298 https://crispr.tyerslab.com/wiki/results/exp298?rev=1767843420&do=diff Sucrose 20000μM R06 exp298 Mechanism of Action Disaccharide composed of glucose and fructose * Class / Subclass 1: Metabolism / Nutrient Technical Notes * PubChem Name: Sucrose * Synonyms: D-(+)-Saccharose * CAS #: 57-50-1 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Talazoparib 0.006μM R06 exp299 https://crispr.tyerslab.com/wiki/results/exp299?rev=1767843420&do=diff Talazoparib 0.006μM R06 exp299 Mechanism of Action Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers * Class / Subclass 1: DNA Damage, Repair and Replication / PARP Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) VE-822 0.04μM R06 exp300 https://crispr.tyerslab.com/wiki/results/exp300?rev=1767843420&do=diff VE-822 0.04μM R06 exp300 Mechanism of Action Inhibits ATR * Class / Subclass 1: DNA Damage, Repair and Replication / Checkpoint Signaling Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) VER-155008 3.9μM R06 exp301 https://crispr.tyerslab.com/wiki/results/exp301?rev=1767843420&do=diff VER-155008 3.9μM R06 exp301 Mechanism of Action Inhibits HSP70 * Class / Subclass 1: Proteostasis / Chaperone Inhibitor Technical Notes * PubChem Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 35°C R06 exp302 https://crispr.tyerslab.com/wiki/results/exp302?rev=1767843420&do=diff 35°C R06 exp302 Mechanism of Action Reduced growth temperature * Class / Subclass 1: Environmental Stresses / Stress Condition Screen Summary * Round: 06 * Dose: N/A * Days of incubation: 8 * Doublings: 6.4 * Numbers of reads: 7989918 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 39°C R06 exp303 https://crispr.tyerslab.com/wiki/results/exp303?rev=1767843420&do=diff 39°C R06 exp303 Mechanism of Action Elevated growth temperature * Class / Subclass 1: Environmental Stresses / Stress Condition Screen Summary * Round: 06 * Dose: N/A * Days of incubation: 8 * Doublings: 7.8 * Numbers of reads: 6641990 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 2μM R07 exp306 https://crispr.tyerslab.com/wiki/results/exp306?rev=1767843420&do=diff Rapamycin 2μM R07 exp306 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307 https://crispr.tyerslab.com/wiki/results/exp307?rev=1767843420&do=diff Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 2μM plus FK-506 5μM R07 exp308 https://crispr.tyerslab.com/wiki/results/exp308?rev=1767843420&do=diff Rapamycin 2μM plus FK-506 5μM R07 exp308 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 2-Methoxyestradiol 0.55μM R07 exp310 https://crispr.tyerslab.com/wiki/results/exp310?rev=1767843420&do=diff 2-Methoxyestradiol 0.55μM R07 exp310 Mechanism of Action Endogenous estradiol metabolite, weak agonist for estrogen receptor, agonist of GPER1, microtubule destabilizer * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / GPCR Agonist text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 https://crispr.tyerslab.com/wiki/results/exp311?rev=1767843420&do=diff 2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 Mechanism of Action Endogenous estradiol metabolite, weak agonist for estrogen receptor, agonist of GPER1, microtubule destabilizer * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 https://crispr.tyerslab.com/wiki/results/exp312?rev=1767843420&do=diff 2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 Mechanism of Action Endogenous estradiol metabolite, weak agonist for estrogen receptor, agonist of GPER1, microtubule destabilizer * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dimethyloxaloylglycine 11μM R07 exp314 https://crispr.tyerslab.com/wiki/results/exp314?rev=1767843420&do=diff Dimethyloxaloylglycine 11μM R07 exp314 Mechanism of Action Prolylhydroxylase inhibitor, induces HIF-1α accumulation * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor * Class / Subclass 2: Signal Transduction / Other inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Geldanamycin 0.015 to 0.025μM on day4 R07 exp316 https://crispr.tyerslab.com/wiki/results/exp316?rev=1767843420&do=diff Geldanamycin 0.015 to 0.025μM on day4 R07 exp316 Mechanism of Action HSP90 inhibitor * Class / Subclass 1: Proteostasis / Chaperone Inhibitor Technical Notes * PubChem Name: Geldanamycin * Synonyms: N/A * CAS #: 30562-34-6 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Geldanamycin 0.015 to 0.05μM on day4 R07 exp317 https://crispr.tyerslab.com/wiki/results/exp317?rev=1767843420&do=diff Geldanamycin 0.015 to 0.05μM on day4 R07 exp317 Mechanism of Action HSP90 inhibitor * Class / Subclass 1: Proteostasis / Chaperone Inhibitor Technical Notes * PubChem Name: Geldanamycin * Synonyms: N/A * CAS #: 30562-34-6 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 5μM R07 exp318 https://crispr.tyerslab.com/wiki/results/exp318?rev=1767843420&do=diff ABT-702 5μM R07 exp318 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Adenosine Kinase Inhibitor * Synonyms: N/A * CAS #: 1188890-28-9 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319 https://crispr.tyerslab.com/wiki/results/exp319?rev=1767843420&do=diff ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes ABT-702 * PubChem Name: Adenosine Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 5μM plus CoCl2 18μM R07 exp320 https://crispr.tyerslab.com/wiki/results/exp320?rev=1767843420&do=diff ABT-702 5μM plus CoCl2 18μM R07 exp320 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes ABT-702 * PubChem Name: Adenosine Kinase Inhibitor * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ABT-702 5μM plus Deferoxamine 11μM R07 exp321 https://crispr.tyerslab.com/wiki/results/exp321?rev=1767843420&do=diff ABT-702 5μM plus Deferoxamine 11μM R07 exp321 Mechanism of Action Inhibits adenosine kinase (ADK) * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes ABT-702 * PubChem Name: Adenosine Kinase Inhibitor * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CCT251545 20μM R07 exp326 https://crispr.tyerslab.com/wiki/results/exp326?rev=1767843420&do=diff CCT251545 20μM R07 exp326 Mechanism of Action Inhibits CDK8 and CDK19 mediator-associated kinases * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hydroxyurea 100μM R07 exp329 https://crispr.tyerslab.com/wiki/results/exp329?rev=1767843420&do=diff Hydroxyurea 100μM R07 exp329 Mechanism of Action Inhibits ribonucleotide reductase, scavenges tyrosyl radicals * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 5-Azacytidine 2μM R07 exp330 https://crispr.tyerslab.com/wiki/results/exp330?rev=1767843420&do=diff 5-Azacytidine 2μM R07 exp330 Mechanism of Action Analog of cytidine ribonucleoside, DNA methyltransferase inhibitor * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: Gene Regulation / Epigenetic Inhibitor * Class / Subclass 3: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) A-769662 20μM R07 exp331 https://crispr.tyerslab.com/wiki/results/exp331?rev=1767843420&do=diff A-769662 20μM R07 exp331 Mechanism of Action Activates AMP-activated protein kinase (AMPK), allosteric * Class / Subclass 1: Signal Transduction / Kinase Activator Technical Notes * PubChem Name: 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Adefovir 20μM R07 exp332 https://crispr.tyerslab.com/wiki/results/exp332?rev=1767843420&do=diff Adefovir 20μM R07 exp332 Mechanism of Action Nucleoside reverse transcriptase inhibitor (NRTI), active against HBV and HSV * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: DNA Damage, Repair and Replication / Reverse Transcriptase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) All-trans-Retinoic-Acid 8μM R07 exp333 https://crispr.tyerslab.com/wiki/results/exp333?rev=1767843420&do=diff All-trans-Retinoic-Acid 8μM R07 exp333 Mechanism of Action Ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR), metabolite of vitamin A1 * Class / Subclass 1: Gene Regulation / Nuclear Receptor Ligand * Class / Subclass 2: Metabolism / Metabolite text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) All-trans-Retinoic-Acid 40μM R07 exp334 https://crispr.tyerslab.com/wiki/results/exp334?rev=1767843420&do=diff All-trans-Retinoic-Acid 40μM R07 exp334 Mechanism of Action Ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR), metabolite of vitamin A1 * Class / Subclass 1: Gene Regulation / Nuclear Receptor Ligand * Class / Subclass 2: Metabolism / Metabolite text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Aminopterin 0.005μM R07 exp335 https://crispr.tyerslab.com/wiki/results/exp335?rev=1767843420&do=diff Aminopterin 0.005μM R07 exp335 Mechanism of Action Inhibits dihydrofolate reductase (DHFR) * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Asunaprenir 3μM R07 exp336 https://crispr.tyerslab.com/wiki/results/exp336?rev=1767843420&do=diff Asunaprenir 3μM R07 exp336 Mechanism of Action Block the enzymatic activity of the HCV NS3 protease * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: Proteostasis / Protease Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BN82002 4μM R07 exp340 https://crispr.tyerslab.com/wiki/results/exp340?rev=1767843420&do=diff BN82002 4μM R07 exp340 Mechanism of Action Inhibits CDC25 phosphatases, active against CDC25A/B/C isoforms * Class / Subclass 1: Cell Cycle / Phosphatase inhibitor * Class / Subclass 2: Signal Transduction / Phosphatase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BRD2 inhibitor II 20μM R07 exp341 https://crispr.tyerslab.com/wiki/results/exp341?rev=1767843420&do=diff BRD2 inhibitor II 20μM R07 exp341 Mechanism of Action Inhibits BRD2, blocks recognition of acetylated H4K12 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: 1-[2-(1H-Benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Calcium Ionophore 0.4μM R07 exp342 https://crispr.tyerslab.com/wiki/results/exp342?rev=1767843420&do=diff Calcium Ionophore 0.4μM R07 exp342 Mechanism of Action Calcium ionophore * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Organelle Function / Membrane Ionophore Technical Notes * PubChem Name: Calcium ionophore A23187 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Centrinone 0.5μM R07 exp343 https://crispr.tyerslab.com/wiki/results/exp343?rev=1767843420&do=diff Centrinone 0.5μM R07 exp343 Mechanism of Action Inhibits PLK4, blocks centriole duplication, causes p53-dependent G1 arrest * Class / Subclass 1: Cell Cycle / Mitotic Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Chlorpromazine 10μM R07 exp344 https://crispr.tyerslab.com/wiki/results/exp344?rev=1767843420&do=diff Chlorpromazine 10μM R07 exp344 Mechanism of Action Antipsychotic, pleiotropic antagonist for dopamine, seratonin, histamine, adrenergic, muscarinic receptors, potassium and sodium channels, also disrupts clathrin-mediated endocytosis * Class / Subclass 1: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cidofovir 10μM R07 exp345 https://crispr.tyerslab.com/wiki/results/exp345?rev=1767843420&do=diff Cidofovir 10μM R07 exp345 Mechanism of Action Acyclic nucleoside phosphonate, inhibits DNA polymerase * Class / Subclass 1: Infectious Disease / Antiviral * Class / Subclass 2: Metabolism / Antimetabolite * Class / Subclass 3: DNA Damage, Repair and Replication / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CoCl2 18μM R07 exp346 https://crispr.tyerslab.com/wiki/results/exp346?rev=1767843420&do=diff CoCl2 18μM R07 exp346 Mechanism of Action Hypoxia mimetic, inhibits VHL-HIF-1α interaction, induces HIF-1α accumulation * Class / Subclass 1: Environmental Stresses / Heavy Metal * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cyclosporin-A 0.8μM R07 exp347 https://crispr.tyerslab.com/wiki/results/exp347?rev=1767843420&do=diff Cyclosporin-A 0.8μM R07 exp347 Mechanism of Action Inhibits calcineurin, forms ternary complex with immunophilin (FBKP) and calcineurin * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: Cyclosporin A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cyclosporin-A 3μM R07 exp348 https://crispr.tyerslab.com/wiki/results/exp348?rev=1767843420&do=diff Cyclosporin-A 3μM R07 exp348 Mechanism of Action Inhibits calcineurin, forms ternary complex with immunophilin (FBKP) and calcineurin * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: Cyclosporin A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cytochalasin-B 5μM R07 exp349 https://crispr.tyerslab.com/wiki/results/exp349?rev=1767843420&do=diff Cytochalasin-B 5μM R07 exp349 Mechanism of Action Binds fast-growing (barbed) end of F-actin filament, inhibits actin polymerization * Class / Subclass 1: Cell Cycle / Cytokinesis Inhibitor * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Deferoxamine 11μM R07 exp350 https://crispr.tyerslab.com/wiki/results/exp350?rev=1767843420&do=diff Deferoxamine 11μM R07 exp350 Mechanism of Action Iron chelator, hypoxia mimetic, induces HIF-1‘± accumulation * Class / Subclass 1: Environmental Stresses / Metal Chelator * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dexamethasone 0.006μM R07 exp351 https://crispr.tyerslab.com/wiki/results/exp351?rev=1767843420&do=diff Dexamethasone 0.006μM R07 exp351 Mechanism of Action Glucocorticoid receptor agonist, anti-inflammatory * Class / Subclass 1: Metabolism / Hormone Agonist * Class / Subclass 2: Signal Transduction / GPCR Agonist Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dexamethasone 0.006 to 0.015μM on day4 R07 exp352 https://crispr.tyerslab.com/wiki/results/exp352?rev=1767843420&do=diff Dexamethasone 0.006 to 0.015μM on day4 R07 exp352 Mechanism of Action Glucocorticoid receptor agonist, anti-inflammatory * Class / Subclass 1: Metabolism / Hormone Agonist * Class / Subclass 2: Signal Transduction / GPCR Agonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Diepoxybutane 3μM R07 exp354 https://crispr.tyerslab.com/wiki/results/exp354?rev=1767843420&do=diff Diepoxybutane 3μM R07 exp354 Mechanism of Action DNA crosslinker, carcinogen * Class / Subclass 1: DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker Technical Notes * PubChem Name: 2,2'-Bioxirane * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dinaciclib 0.007μM R07 exp355 https://crispr.tyerslab.com/wiki/results/exp355?rev=1767843420&do=diff Dinaciclib 0.007μM R07 exp355 Mechanism of Action Inhibits CDK2, CDK5, CDK1, CDK9 * Class / Subclass 1: Cell Cycle / Cell Cycle Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor * Class / Subclass 3: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Docosahexaenoic-acid 50μM R07 exp356 https://crispr.tyerslab.com/wiki/results/exp356?rev=1767843420&do=diff Docosahexaenoic-acid 50μM R07 exp356 Mechanism of Action Essential omega-3 fatty acid * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Docosahexaenoic acid * Synonyms: DHA; Cervonic Acid; DHA;Cervonic Acid * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dorsomorphin 5μM R07 exp357 https://crispr.tyerslab.com/wiki/results/exp357?rev=1767843420&do=diff Dorsomorphin 5μM R07 exp357 Mechanism of Action Putative inhibitor of AMPK and BMP signalling * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Dorsomorphin * Synonyms: BML-275; Compound C * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) FK-506 5μM R07 exp358 https://crispr.tyerslab.com/wiki/results/exp358?rev=1767843420&do=diff FK-506 5μM R07 exp358 Mechanism of Action Inhibits calcineurin * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: Tacrolimus * Synonyms: FK506; Fujimycin; FR900506 * CAS #: 104987-11-3 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) FK-506 30μM R07 exp359 https://crispr.tyerslab.com/wiki/results/exp359?rev=1767843420&do=diff FK-506 30μM R07 exp359 Mechanism of Action Inhibits calcineurin * Class / Subclass 1: Signal Transduction / Phosphatase Inhibitor Technical Notes * PubChem Name: Tacrolimus * Synonyms: FK506; Fujimycin; FR900506 * CAS #: 104987-11-3 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Genistein 15μM R07 exp360 https://crispr.tyerslab.com/wiki/results/exp360?rev=1767843420&do=diff Genistein 15μM R07 exp360 Mechanism of Action Inhibits tyrosine kinases, phytoestrogen, toposiomerase II, pleiotropic effects * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Metabolism / Hormone Agonist * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK-J4 1μM R07 exp362 https://crispr.tyerslab.com/wiki/results/exp362?rev=1767843420&do=diff GSK-J4 1μM R07 exp362 Mechanism of Action JMJD3/KDM6B, UTX/KDM6A histone demethylase inhibitor (H3K27me2/me3) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: GSK J4 HCl * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK-J4 1-1.25μM to day4 R07 exp363 https://crispr.tyerslab.com/wiki/results/exp363?rev=1767843420&do=diff GSK-J4 1-1.25μM to day4 R07 exp363 Mechanism of Action JMJD3/KDM6B, UTX/KDM6A histone demethylase inhibitor (H3K27me2/me3) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: GSK J4 HCl * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) I-BRD9 4μM R07 exp365 https://crispr.tyerslab.com/wiki/results/exp365?rev=1767843420&do=diff I-BRD9 4μM R07 exp365 Mechanism of Action Inhibits BRD9 subunit of SWI/SNF complex * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: N'-(1,1-Dioxothian-4-yl)-5-ethyl-4-oxo-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ibrutinib 1μM R07 exp372 https://crispr.tyerslab.com/wiki/results/exp372?rev=1767843420&do=diff Ibrutinib 1μM R07 exp372 Mechanism of Action Inhibits BTK * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Ibrutinib * Synonyms: PCI-32765 * CAS #: 936563-96-1 * PubChem CID: 24821094 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Latrunculin-B 10μM R07 exp374 https://crispr.tyerslab.com/wiki/results/exp374?rev=1767843420&do=diff Latrunculin-B 10μM R07 exp374 Mechanism of Action Binds actin monomers, inhibits actin polymerization * Class / Subclass 1: Cell Cycle / Cytokinesis Inhibitor * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor * Class / Subclass 3: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Lenalidomide 20μM R07 exp375 https://crispr.tyerslab.com/wiki/results/exp375?rev=1767843420&do=diff Lenalidomide 20μM R07 exp375 Mechanism of Action IMiD that targets IKZF1/3 for ubiquitination by CUL4-cereblon complex * Class / Subclass 1: Proteostasis / Bivalent Ligand Technical Notes * PubChem Name: Lenalidomide * Synonyms: CC-5013 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Losmapimod 1μM R07 exp376 https://crispr.tyerslab.com/wiki/results/exp376?rev=1767843420&do=diff Losmapimod 1μM R07 exp376 Mechanism of Action Inhibits p38‘±/‘_ MAP kinases * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Losmapimod * Synonyms: GSK-AHAB; GW856553X; SB856553 * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MSC2530818 10μM R07 exp379 https://crispr.tyerslab.com/wiki/results/exp379?rev=1767843420&do=diff MSC2530818 10μM R07 exp379 Mechanism of Action Inhibits CDK8 * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: [(2s)-2-(4-Chlorophenyl)pyrrolidin-1-Yl](3-Methyl-1h-Pyrazolo[3,4-B]pyridin-5-Yl)methanone text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NMS-873 0.07μM R07 exp380 https://crispr.tyerslab.com/wiki/results/exp380?rev=1767843420&do=diff NMS-873 0.07μM R07 exp380 Mechanism of Action Inhibits p97 AAA-ATPase * Class / Subclass 1: Proteostasis / Ubiquitin-Proteasome Inhibitor Technical Notes * PubChem Name: CID 71521142 * Synonyms: N/A * CAS #: 1418013-75-8 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Palbociclib 1μM R07 exp382 https://crispr.tyerslab.com/wiki/results/exp382?rev=1767843420&do=diff Palbociclib 1μM R07 exp382 Mechanism of Action Inhibits CDK4 and CDK6, causes G1 arrest * Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PF-06409577 20μM R07 exp389 https://crispr.tyerslab.com/wiki/results/exp389?rev=1767843420&do=diff PF-06409577 20μM R07 exp389 Mechanism of Action Activates AMPK, lowers cholesterol levels in NAFLD/NASH preclinical models * Class / Subclass 1: Signal Transduction / Kinase Activator Technical Notes * PubChem Name: 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pifithrin-alpha 20μM R07 exp390 https://crispr.tyerslab.com/wiki/results/exp390?rev=1767843420&do=diff Pifithrin-alpha 20μM R07 exp390 Mechanism of Action Claimed to inhibit p53 but has p53-independent effects, cyclic form may increase stem cell reprogramming * Class / Subclass 1: Signal Transduction / Apoptosis Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pomalidomide 20μM R07 exp391 https://crispr.tyerslab.com/wiki/results/exp391?rev=1767843420&do=diff Pomalidomide 20μM R07 exp391 Mechanism of Action IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex * Class / Subclass 1: Proteostasis / Ubiquitin-Proteasome Activator Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PT-1 25μM R07 exp392 https://crispr.tyerslab.com/wiki/results/exp392?rev=1767843420&do=diff PT-1 25μM R07 exp392 Mechanism of Action Activates AMPK, selectivefor ‘_1-complexes, may antagonize autoinhibition * Class / Subclass 1: Signal Transduction / Kinase Activator Technical Notes * PubChem Name: 2-Chloro-5-[[(5Z)-5-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Resminostat 0.5μM R07 exp393 https://crispr.tyerslab.com/wiki/results/exp393?rev=1767843420&do=diff Resminostat 0.5μM R07 exp393 Mechanism of Action Inhibits HDAC 1, HDAC3, HDAC6 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Resminostat (hydrochloride) * Synonyms: RAS2410 hydrochloride; 4SC-201 hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Salubrinal 20μM R07 exp399 https://crispr.tyerslab.com/wiki/results/exp399?rev=1767843420&do=diff Salubrinal 20μM R07 exp399 Mechanism of Action Inhibits eIF2‘± phosphatase, indirectly inhibits eIF2‘± * Class / Subclass 1: Proteostasis / Translation Inhibitor Technical Notes * PubChem Name: Salubrinal * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Senexin-A 25μM R07 exp400 https://crispr.tyerslab.com/wiki/results/exp400?rev=1767843420&do=diff Senexin-A 25μM R07 exp400 Mechanism of Action Inhibits CDK8, suppresses induction of gene expression * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Gene Regulation / Transcription Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SNS-032 25μM R07 exp401 https://crispr.tyerslab.com/wiki/results/exp401?rev=1767843420&do=diff SNS-032 25μM R07 exp401 Mechanism of Action Inhibits CDK2, CDK7, CDK9 * Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Sns-032 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tenofovir 10μM R07 exp405 https://crispr.tyerslab.com/wiki/results/exp405?rev=1767843420&do=diff Tenofovir 10μM R07 exp405 Mechanism of Action Nucleoside reverse transcriptase inhibitor, chain terminator * Class / Subclass 1: Infectious Disease / Antiviral Technical Notes * PubChem Name: Tenofovir * Synonyms: GS 1278; PMPA; TDF * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Thalidomide 20μM R07 exp406 https://crispr.tyerslab.com/wiki/results/exp406?rev=1767843420&do=diff Thalidomide 20μM R07 exp406 Mechanism of Action IMiD that targets neo-substrates IKZF1/3 for ubiquitination by CUL4A-DDB1-cereblon complex * Class / Subclass 1: Proteostasis / Bivalent Ligand Technical Notes * PubChem Name: Thalidomide * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Thapsigargin 0.005μM R07 exp407 https://crispr.tyerslab.com/wiki/results/exp407?rev=1767843420&do=diff Thapsigargin 0.005μM R07 exp407 Mechanism of Action Inhibits sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), non-competitive inhibitor, raises intracellular calcium concentration * Class / Subclass 1: Organelle Function / Membrane Transport Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ531 0.11μM R07 exp409 https://crispr.tyerslab.com/wiki/results/exp409?rev=1767843420&do=diff THZ531 0.11μM R07 exp409 Mechanism of Action Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ531 0.11 to 0.125μM on day4 R07 exp410 https://crispr.tyerslab.com/wiki/results/exp410?rev=1767843420&do=diff THZ531 0.11 to 0.125μM on day4 R07 exp410 Mechanism of Action Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412 https://crispr.tyerslab.com/wiki/results/exp412?rev=1767843420&do=diff THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412 Mechanism of Action Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ531 0.11 to 0.175μM on day4 R07 exp413 https://crispr.tyerslab.com/wiki/results/exp413?rev=1767843420&do=diff THZ531 0.11 to 0.175μM on day4 R07 exp413 Mechanism of Action Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tozasertib 0.1μM R07 exp414 https://crispr.tyerslab.com/wiki/results/exp414?rev=1767843420&do=diff Tozasertib 0.1μM R07 exp414 Mechanism of Action Inhibits Aurora A,B,C kinases, blocks cytokinesis, also inhibits RIPK1 and blocks necroptosis * Class / Subclass 1: Cell Cycle / Cytokinesis Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Trichostatin-A 0.06μM R07 exp415 https://crispr.tyerslab.com/wiki/results/exp415?rev=1767843420&do=diff Trichostatin-A 0.06μM R07 exp415 Mechanism of Action Inhibits class I and II HDAC enzymes * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor * Class / Subclass 2: Infectious Disease / Antifungal Technical Notes * PubChem Name: Trichostatin A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tubacin 1.6μM R07 exp416 https://crispr.tyerslab.com/wiki/results/exp416?rev=1767843420&do=diff Tubacin 1.6μM R07 exp416 Mechanism of Action Inhibits HDAC6 selectively * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Tubacin * Synonyms: N/A * CAS #: 537049-40-4 * PubChem CID: 6675804 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tubastatin-A 2.5μM R07 exp417 https://crispr.tyerslab.com/wiki/results/exp417?rev=1767843420&do=diff Tubastatin-A 2.5μM R07 exp417 Mechanism of Action Inhibits HDAC6 selectively * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Tubastatin A * Synonyms: N/A * CAS #: 1252003-15-8 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tunicamycin 0.04μM R07 exp418 https://crispr.tyerslab.com/wiki/results/exp418?rev=1767843420&do=diff Tunicamycin 0.04μM R07 exp418 Mechanism of Action Inhibits GlcNAc phosphotransferase (GPT), blocks N-linked glycoslylation, induces protein unfolding in ER, nucleoside antibiotic * Class / Subclass 1: Proteostasis / Unfolded Protein Response Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tunicamycin 0.04 to 0.075μM on day4 R07 exp419 https://crispr.tyerslab.com/wiki/results/exp419?rev=1767843420&do=diff Tunicamycin 0.04 to 0.075μM on day4 R07 exp419 Mechanism of Action Inhibits GlcNAc phosphotransferase (GPT), blocks N-linked glycoslylation, induces protein unfolding in ER, nucleoside antibiotic * Class / Subclass 1: Proteostasis / Unfolded Protein Response Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tunicamycin 0.04 to 0.125μM on day4 R07 exp420 https://crispr.tyerslab.com/wiki/results/exp420?rev=1767843420&do=diff Tunicamycin 0.04 to 0.125μM on day4 R07 exp420 Mechanism of Action Inhibits GlcNAc phosphotransferase (GPT), blocks N-linked glycoslylation, induces protein unfolding in ER, nucleoside antibiotic * Class / Subclass 1: Proteostasis / Unfolded Protein Response Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) VHL-ligand-1 20μM R07 exp421 https://crispr.tyerslab.com/wiki/results/exp421?rev=1767843420&do=diff VHL-ligand-1 20μM R07 exp421 Mechanism of Action Binds VHL, targeting moiety for PROTACs * Class / Subclass 1: Proteostasis / Bivalent Ligand Technical Notes * PubChem Name: Protein degrader 1 hydrochloride * Synonyms: N/A * CAS #: 1448189-80-7 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Wiskostatin 3μM R07 exp422 https://crispr.tyerslab.com/wiki/results/exp422?rev=1767843420&do=diff Wiskostatin 3μM R07 exp422 Mechanism of Action Inhibits N-WASP, blocks actin polymerization * Class / Subclass 1: Organelle Function / Cytoskeletal Inhibitor * Class / Subclass 2: Cell Cycle / Actin Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Zebularine 20μM R07 exp423 https://crispr.tyerslab.com/wiki/results/exp423?rev=1767843420&do=diff Zebularine 20μM R07 exp423 Mechanism of Action Inhibits cytidine deaminase, transition state analog, also inhibits DNMT1 via reversible covalent complex * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Beta-Estradiol 0.55μM R07 exp425 https://crispr.tyerslab.com/wiki/results/exp425?rev=1767843420&do=diff Beta-Estradiol 0.55μM R07 exp425 Mechanism of Action Agonist for estrogen receptor (ER), inactive control for 2-Methoxyestradiol * Class / Subclass 1: Gene Regulation / Transcription Activator * Class / Subclass 2: Metabolism / Hormone Agonist text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) FBS-Wisent 0.1 R07 exp426 https://crispr.tyerslab.com/wiki/results/exp426?rev=1767843420&do=diff FBS-Wisent 0.1 R07 exp426 Mechanism of Action Unknown, poor batch of FBS * Class / Subclass 1: Environmental Stresses / Toxin Screen Summary * Round: 07 * Dose: 10% * Days of incubation: 8 * Doublings: 5.4 * Numbers of reads: 23344123 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rapamycin 0.001μM R08 exp429 https://crispr.tyerslab.com/wiki/results/exp429?rev=1767843420&do=diff Rapamycin 0.001μM R08 exp429 Mechanism of Action Allosteric mTORC1 inhibitor, forms ternary complex with FKBP12 and mTOR, attenuates protein synthesis and metabolism * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rifampicin 30μM R08 exp430 https://crispr.tyerslab.com/wiki/results/exp430?rev=1767843420&do=diff Rifampicin 30μM R08 exp430 Mechanism of Action Inhibits bacterial RNA polymerase, induces hepatic cytochrome P450 enzymes * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Rifampicin * Synonyms: Rifampin; Rifamycin AMP text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rotenone 0.07μM R08 exp431 https://crispr.tyerslab.com/wiki/results/exp431?rev=1767843420&do=diff Rotenone 0.07μM R08 exp431 Mechanism of Action Inhibits complex I, blocks electron transfer from iron-sulfur centers to ubiquinone, generates ROS, also inhibits microtubule assembly * Class / Subclass 1: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) YM155 0.001μM R08 exp432 https://crispr.tyerslab.com/wiki/results/exp432?rev=1767843420&do=diff YM155 0.001μM R08 exp432 Mechanism of Action Inhibits expression of survivin, amongst other ascribed mechanisms * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Apoptosis Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LJH685 50μM R08 exp433 https://crispr.tyerslab.com/wiki/results/exp433?rev=1767843420&do=diff LJH685 50μM R08 exp433 Mechanism of Action Inhibits p90 ribosomal S6 kinase (RSK) * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 2,6-Difluoro-4-{4-[4-(4-Methylpiperazin-1-Yl)phenyl]pyridin-3-Yl}phenol text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vemurafenib 6.6μM R08 exp434 https://crispr.tyerslab.com/wiki/results/exp434?rev=1767843420&do=diff Vemurafenib 6.6μM R08 exp434 Mechanism of Action Inhibits BRAF-V300E, paradoxical RAF activation by stabilization of CRAF/BRAF heterodimer * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Vemurafenib text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) JQ1 0.8μM R08 exp435 https://crispr.tyerslab.com/wiki/results/exp435?rev=1767843420&do=diff JQ1 0.8μM R08 exp435 Mechanism of Action Inhibits BET bromodomain proteins BRD2, BRD3, BRD4, BRDT * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: JQ1 compound * Synonyms: JQ1 * CAS #: 1268524-70-4 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dynasore 7μM R08 exp436 https://crispr.tyerslab.com/wiki/results/exp436?rev=1767843420&do=diff Dynasore 7μM R08 exp436 Mechanism of Action Putative dynamin GTPase inhibitor, blocks endocytosis * Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor Technical Notes * PubChem Name: Dynasore * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ethanol 0.003 R08 exp437 https://crispr.tyerslab.com/wiki/results/exp437?rev=1767843420&do=diff Ethanol 0.003 R08 exp437 Mechanism of Action Pleiotropic effects on membranes, ion channels, enzymes, receptors * Class / Subclass 1: Environmental Stresses / Solvent Technical Notes * PubChem Name: Ethanol * Synonyms: N/A * CAS #: 64-17-5 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NN-Diethyl-meta-toluamide 500μM R08 exp438 https://crispr.tyerslab.com/wiki/results/exp438?rev=1767843420&do=diff NN-Diethyl-meta-toluamide 500μM R08 exp438 Mechanism of Action Insect repellent * Class / Subclass 1: Environmental Stresses / Environmental Contaminant Technical Notes * PubChem Name: N,N-Diethyl-3-methylbenzamide * Synonyms: DEET; N,N-Diethyl-m-toluamide; DEET;N,N-Diethyl-m-toluamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) QNZ 0.01μM R08 exp439 https://crispr.tyerslab.com/wiki/results/exp439?rev=1767843420&do=diff QNZ 0.01μM R08 exp439 Mechanism of Action Inhibits NF-κB activation, TNF-α production * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Apoptosis Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Aphidicolin 0.4μM R08 exp440 https://crispr.tyerslab.com/wiki/results/exp440?rev=1767843420&do=diff Aphidicolin 0.4μM R08 exp440 Mechanism of Action Inhibits DNA polymerases Polα, Polδ, Polϵ and Polζ * Class / Subclass 1: DNA Damage, Repair and Replication / Replication Inhibitor * Class / Subclass 2: Cell Cycle / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK-J4 1.5μM R08 exp441 https://crispr.tyerslab.com/wiki/results/exp441?rev=1767843420&do=diff GSK-J4 1.5μM R08 exp441 Mechanism of Action JMJD3/KDM6B, UTX/KDM6A histone demethylase inhibitor (H3K27me2/me3) * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: GSK J4 HCl * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ibrutinib 10μM R08 exp442 https://crispr.tyerslab.com/wiki/results/exp442?rev=1767843420&do=diff Ibrutinib 10μM R08 exp442 Mechanism of Action Inhibits BTK * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Ibrutinib * Synonyms: PCI-32765 * CAS #: 936563-96-1 * PubChem CID: 24821094 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) SNS-032 15μM R08 exp443 https://crispr.tyerslab.com/wiki/results/exp443?rev=1767843420&do=diff SNS-032 15μM R08 exp443 Mechanism of Action Inhibits CDK2, CDK7, CDK9 * Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Sns-032 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ531 0.225μM R08 exp444 https://crispr.tyerslab.com/wiki/results/exp444?rev=1767843420&do=diff THZ531 0.225μM R08 exp444 Mechanism of Action Inhibits CDK12 and CDK13, forms covalent adduct, more selective analog of THZ1, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ∆-9-Tetrahydrocannabinol 30μM R08 exp445 https://crispr.tyerslab.com/wiki/results/exp445?rev=1767843420&do=diff ∆-9-Tetrahydrocannabinol 30μM R08 exp445 Mechanism of Action Agonist of CB1 and CB2 cannabinoid receptors * Class / Subclass 1: Environmental Stresses / Controlled Substance * Class / Subclass 2: Signal Transduction / GPCR Agonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 https://crispr.tyerslab.com/wiki/results/exp446?rev=1767843420&do=diff 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 Mechanism of Action UV mimetic, metabolized to electrohpile that forms stable quinolone monoadducts * Class / Subclass 1: DNA Damage, Repair and Replication / Helix-Distorting Adduct Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Amiloride 100μM R08 exp447 https://crispr.tyerslab.com/wiki/results/exp447?rev=1767843420&do=diff Amiloride 100μM R08 exp447 Mechanism of Action Inhibits epithelial sodium channel (ENaC) and other Na+/H+ channels, also inhibits urokinase-type plasminogen activator (uPA) * Class / Subclass 1: Signal Transduction / Ion Channel Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ammonium tetrathiomolybdate 10μM R08 exp448 https://crispr.tyerslab.com/wiki/results/exp448?rev=1767843420&do=diff Ammonium tetrathiomolybdate 10μM R08 exp448 Mechanism of Action Inhibits cuproenzymes superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX) * Class / Subclass 1: Environmental Stresses / Metal Chelator * Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Arsenic trioxide 60μM R08 exp449 https://crispr.tyerslab.com/wiki/results/exp449?rev=1767843420&do=diff Arsenic trioxide 60μM R08 exp449 Mechanism of Action Induces degradation of aberrant PML-RAR‘± fusion protein in acute promyelocytic leukemia * Class / Subclass 1: Environmental Stresses / Heavy Metal * Class / Subclass 2: Signal Transduction / Apoptosis Inducer text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Artemisinin 50μM R08 exp450 https://crispr.tyerslab.com/wiki/results/exp450?rev=1767843420&do=diff Artemisinin 50μM R08 exp450 Mechanism of Action Sesquiterpene endoperoxide activated by heme, kills malaria parasite through oxidative damage * Class / Subclass 1: Infectious Disease / Antimalarial Technical Notes * PubChem Name: Artemisinin text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Atovaquone 15μM R08 exp451 https://crispr.tyerslab.com/wiki/results/exp451?rev=1767843420&do=diff Atovaquone 15μM R08 exp451 Mechanism of Action Ubiquinone analog, inhibits mitochondrial complex III, induces DNA strand breaks * Class / Subclass 1: Infectious Disease / Antimalarial * Class / Subclass 2: Organelle Function / Mitochondrial Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Azithromycin 100μM R08 exp452 https://crispr.tyerslab.com/wiki/results/exp452?rev=1767843420&do=diff Azithromycin 100μM R08 exp452 Mechanism of Action Binds 50S subunit of bacterial ribosome, inhibits translation * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Proteostasis / Translation Inhibitor Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) B02 10μM R08 exp453 https://crispr.tyerslab.com/wiki/results/exp453?rev=1767843420&do=diff B02 10μM R08 exp453 Mechanism of Action Inhibits RAD51 recombinase, blocks homologous recombination * Class / Subclass 1: DNA Damage, Repair and Replication / Repair Protein Inhibitor Technical Notes * PubChem Name: RAD51 inhibitor B02 * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bafilomycin-A1 0.009μM R08 exp454 https://crispr.tyerslab.com/wiki/results/exp454?rev=1767843420&do=diff Bafilomycin-A1 0.009μM R08 exp454 Mechanism of Action Inhibits vacuolar-type H+ ATPase, blocks acidification of lysosome * Class / Subclass 1: Signal Transduction / Ion Channel Inhibitor * Class / Subclass 2: Organelle Function / Membrane Transport Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Benzoate 10000μM R08 exp455 https://crispr.tyerslab.com/wiki/results/exp455?rev=1767843420&do=diff Benzoate 10000μM R08 exp455 Mechanism of Action Food additive (E211), bacteriostatic and fungistatic * Class / Subclass 1: Environmental Stresses / Food Preservative Technical Notes * PubChem Name: Sodium benzoate * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Benzoate 20000μM R08 exp456 https://crispr.tyerslab.com/wiki/results/exp456?rev=1767843420&do=diff Benzoate 20000μM R08 exp456 Mechanism of Action Food additive (E211), bacteriostatic and fungistatic * Class / Subclass 1: Environmental Stresses / Food Preservative Technical Notes * PubChem Name: Sodium benzoate * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bisphenol F 50μM R08 exp457 https://crispr.tyerslab.com/wiki/results/exp457?rev=1767843420&do=diff Bisphenol F 50μM R08 exp457 Mechanism of Action BPA analog and substitute, endocrine disrupter * Class / Subclass 1: Environmental Stresses / Industrial Chemical Technical Notes * PubChem Name: 4,4'-Methylenediphenol * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bisphenol S 100μM R08 exp458 https://crispr.tyerslab.com/wiki/results/exp458?rev=1767843420&do=diff Bisphenol S 100μM R08 exp458 Mechanism of Action BPA analog and substitute in BPA-free plastics, endocrine disrupter * Class / Subclass 1: Environmental Stresses / Industrial Chemical Technical Notes * PubChem Name: 4,4'-Sulfonyldiphenol * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Bleomycin 5μM R08 exp459 https://crispr.tyerslab.com/wiki/results/exp459?rev=1767843420&do=diff Bleomycin 5μM R08 exp459 Mechanism of Action Induces DNA strand breaks, possibly by iron chelation and ROS generation, or generation of alkali-labile lesions * Class / Subclass 1: DNA Damage, Repair and Replication / Clastogen Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BML-284 0.09μM R08 exp460 https://crispr.tyerslab.com/wiki/results/exp460?rev=1767843420&do=diff BML-284 0.09μM R08 exp460 Mechanism of Action Wnt agonist, GSK3-‘_ dependent, activates ‘_-catenin/TCF-dependent transcription * Class / Subclass 1: Signal Transduction / GPCR Agonist * Class / Subclass 2: Gene Regulation / Transcription Activator text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) BS-181 20μM R08 exp461 https://crispr.tyerslab.com/wiki/results/exp461?rev=1767843420&do=diff BS-181 20μM R08 exp461 Mechanism of Action Inhibits CDK7, causes G1 arrest and apoptosis * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cadmium 60μM R08 exp462 https://crispr.tyerslab.com/wiki/results/exp462?rev=1767843420&do=diff Cadmium 60μM R08 exp462 Mechanism of Action Widely used metal in manufacturing and pigments, known carcinogen * Class / Subclass 1: Environmental Stresses / Heavy Metal Technical Notes * PubChem Name: Cadmium chloride * Synonyms: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Caffeine 2600μM R08 exp463 https://crispr.tyerslab.com/wiki/results/exp463?rev=1767843420&do=diff Caffeine 2600μM R08 exp463 Mechanism of Action CNS stimulant, antagonist of adenosine receptors, inhibits phosphodiesterases, modulates intracellular calcium * Class / Subclass 1: Signal Transduction / GPCR Antagonist * Class / Subclass 2: Environmental Stresses / Food Additive text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Calcipotriol 5μM R08 exp464 https://crispr.tyerslab.com/wiki/results/exp464?rev=1767843420&do=diff Calcipotriol 5μM R08 exp464 Mechanism of Action Synthetic vitamin D3 analog, binds vitamin D nuclear hormone receptor * Class / Subclass 1: Metabolism / Vitamin * Class / Subclass 2: Signal Transduction / Nuclear Receptor Ligand Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cannabidiol 13μM R08 exp465 https://crispr.tyerslab.com/wiki/results/exp465?rev=1767843420&do=diff Cannabidiol 13μM R08 exp465 Mechanism of Action Negative allosteric modulator of cannabinoid CB1 receptor * Class / Subclass 1: Environmental Stresses / Psychoactive Drug * Class / Subclass 2: Signal Transduction / GPCR Antagonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cannabidiol 20μM R08 exp466 https://crispr.tyerslab.com/wiki/results/exp466?rev=1767843420&do=diff Cannabidiol 20μM R08 exp466 Mechanism of Action Negative allosteric modulator of cannabinoid CB1 receptor * Class / Subclass 1: Environmental Stresses / Psychoactive Drug * Class / Subclass 2: Signal Transduction / GPCR Antagonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CAY10603 0.55μM R08 exp467 https://crispr.tyerslab.com/wiki/results/exp467?rev=1767843420&do=diff CAY10603 0.55μM R08 exp467 Mechanism of Action Inhibits HDAC6, selective over other HDACs * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: HDAC6 Inhibitor * Synonyms: BML-281 * CAS #: 1045792-66-2 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CB-5083 0.4μM R08 exp468 https://crispr.tyerslab.com/wiki/results/exp468?rev=1767843420&do=diff CB-5083 0.4μM R08 exp468 Mechanism of Action Inhibits p97 AAA-ATPase * Class / Subclass 1: Proteostasis / Unfoldase Inhibitor Technical Notes * PubChem Name: CB-5083 * Synonyms: N/A * CAS #: 1542705-92-9 * PubChem CID: 73051434 * IUPAC: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CFI-400945 25μM R08 exp469 https://crispr.tyerslab.com/wiki/results/exp469?rev=1767843420&do=diff CFI-400945 25μM R08 exp469 Mechanism of Action Inhibits PLK4, blocks centriole duplication, induces mitotic defects and cell death * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Cell Cycle / Mitotic Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Chloroquine 32μM R08 exp470 https://crispr.tyerslab.com/wiki/results/exp470?rev=1767843420&do=diff Chloroquine 32μM R08 exp470 Mechanism of Action Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, enhances hematin-induced red blood cell lysis, also intercalates into DNA * Class / Subclass 1: Infectious Disease / Antimalarial text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471 https://crispr.tyerslab.com/wiki/results/exp471?rev=1767843420&do=diff Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471 Mechanism of Action Major membrane lipid, precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D * Class / Subclass 1: Metabolism / Metabolite Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CI-1040 9.5μM R08 exp472 https://crispr.tyerslab.com/wiki/results/exp472?rev=1767843420&do=diff CI-1040 9.5μM R08 exp472 Mechanism of Action Inhibits MEK1, blocks ERK1/2 activation * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Cincreasin 100μM R08 exp473 https://crispr.tyerslab.com/wiki/results/exp473?rev=1767843420&do=diff Cincreasin 100μM R08 exp473 Mechanism of Action Inhibits budding yeast Mps1 but not human MPS1 (TTK), overrides spindle checkpoint * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CR131-b 0.005μM R08 exp474 https://crispr.tyerslab.com/wiki/results/exp474?rev=1767843420&do=diff CR131-b 0.005μM R08 exp474 Mechanism of Action Inhibits EIF4A, blocks translation by trapping EIF4A on mRNA at poly-purine sites * Class / Subclass 1: Proteostasis / Translation Inhibitor Technical Notes * PubChem Name: (1R,2R,3S,3Ar,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) CyclicAMP 200μM R08 exp475 https://crispr.tyerslab.com/wiki/results/exp475?rev=1767843420&do=diff CyclicAMP 200μM R08 exp475 Mechanism of Action Second messenger, activates PKA, ion channels, cyclic nucleotide-binding proteins * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / Kinase Activator Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Dihydrosphingosine 8μM R08 exp476 https://crispr.tyerslab.com/wiki/results/exp476?rev=1767843420&do=diff Dihydrosphingosine 8μM R08 exp476 Mechanism of Action Inhibits cytosolic phospholipase A2α (cPLA2α) activity * Class / Subclass 1: Metabolism / Metabolite Technical Notes * PubChem Name: Sphinganine * Synonyms: N/A * CAS #: 764-22-7 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) DKK1 89ng/ml R08 exp477 https://crispr.tyerslab.com/wiki/results/exp477?rev=1767843420&do=diff DKK1 89ng/ml R08 exp477 Mechanism of Action Dickkopf1 (DKK1), recombinant protein inhibitor of WNT signaling, binds LRP5/LRP6 co-receptor and KRM1 * Class / Subclass 1: Signal Transduction / GPCR Antagonist Technical Notes * PubChem Name: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Doxorubicin 0.02μM R08 exp478 https://crispr.tyerslab.com/wiki/results/exp478?rev=1767843420&do=diff Doxorubicin 0.02μM R08 exp478 Mechanism of Action DNA intercalator, traps topoisomerase II complex * Class / Subclass 1: DNA Damage, Repair and Replication / Topoisomerase II Inhibitor * Class / Subclass 2: Infectious Disease / Antibiotic Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ETC-159 50μM R08 exp480 https://crispr.tyerslab.com/wiki/results/exp480?rev=1767843420&do=diff ETC-159 50μM R08 exp480 Mechanism of Action Inhibits PORCN palmitoyl transferase that modifies WNT ligands * Class / Subclass 1: Signal Transduction / Other Inhibitor Technical Notes * PubChem Name: Etc-159 * Synonyms: ETC-1922159 * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Ethambutol 25μM R08 exp481 https://crispr.tyerslab.com/wiki/results/exp481?rev=1767843420&do=diff Ethambutol 25μM R08 exp481 Mechanism of Action Inhibits arabinosyl transferase, interferes with cell wall formation * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Ethambutol Hydrochloride * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Fas-L 44ng/ml R08 exp482 https://crispr.tyerslab.com/wiki/results/exp482?rev=1767843420&do=diff Fas-L 44ng/ml R08 exp482 Mechanism of Action Ligand for Fas receptor, triggers apoptosis * Class / Subclass 1: Signal Transduction / Other Receptor Agonist Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) FTY720 3μM R08 exp483 https://crispr.tyerslab.com/wiki/results/exp483?rev=1767843420&do=diff FTY720 3μM R08 exp483 Mechanism of Action Agonist of sphingosine 1-phosphate receptor-1 (S1P1), derived from myriocin * Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor Technical Notes * PubChem Name: Fingolimod hydrochloride * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK-J5 1.5μM R08 exp484 https://crispr.tyerslab.com/wiki/results/exp484?rev=1767843420&do=diff GSK-J5 1.5μM R08 exp484 Mechanism of Action Inactive isomer of GSKJ4 * Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor Technical Notes * PubChem Name: Ethyl 3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate;hydrochloride text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) GSK626616 14μM R08 exp485 https://crispr.tyerslab.com/wiki/results/exp485?rev=1767843420&do=diff GSK626616 14μM R08 exp485 Mechanism of Action Inhibits DYRK3, prevents stress granule dissolution, mTORC1 release * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 4(5H)-Thiazolone, 2-((2,6-dichlorophenyl)amino)-5-(6-quinoxalinylmethylene)-, (5Z)- text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Heregulin-B 44ng/ml R08 exp486 https://crispr.tyerslab.com/wiki/results/exp486?rev=1767843420&do=diff Heregulin-B 44ng/ml R08 exp486 Mechanism of Action EGF family ligand for ErbB receptors, a.k.a. neuregulin-1 * Class / Subclass 1: Signal Transduction / Receptor Ligand Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hinokiflavone 12μM R08 exp487 https://crispr.tyerslab.com/wiki/results/exp487?rev=1767843420&do=diff Hinokiflavone 12μM R08 exp487 Mechanism of Action Putative splicing inhibitor, ROS generation * Class / Subclass 1: Uncharacterized Mechanism / Natural Product * Class / Subclass 2: Gene Regulation / Splicing Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hippuristanol 0.12μM R08 exp488 https://crispr.tyerslab.com/wiki/results/exp488?rev=1767843420&do=diff Hippuristanol 0.12μM R08 exp488 Mechanism of Action Inhibits translation by trapping EIF4A on mRNA at poly-purine sites * Class / Subclass 1: Proteostasis / Translation Inhibitor Technical Notes * PubChem Name: Hippuristanol * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hippuristanol 0.12μM R08 exp489 no dilution day6 https://crispr.tyerslab.com/wiki/results/exp489?rev=1767843420&do=diff Hippuristanol 0.12μM R08 exp489 no dilution day6 Mechanism of Action Inhibits translation by trapping EIF4A on mRNA at poly-purine sites * Class / Subclass 1: Proteostasis / Translation Inhibitor Technical Notes * PubChem Name: Hippuristanol text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Hydroxychloroquine 30μM R08 exp490 https://crispr.tyerslab.com/wiki/results/exp490?rev=1767843420&do=diff Hydroxychloroquine 30μM R08 exp490 Mechanism of Action Lysosomotropic agent, prevents sequestration of heme into hemozoin, forms toxic complex with heme, also inhibits TLR 7/9 * Class / Subclass 1: Infectious Disease / Antimalarial * Class / Subclass 2: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) iCRT14 30μM R08 exp492 https://crispr.tyerslab.com/wiki/results/exp492?rev=1767843420&do=diff iCRT14 30μM R08 exp492 Mechanism of Action Inhibits β-catenin-dependent transcription, may alter interaction of β-catenin with TCF4 * Class / Subclass 1: Gene Regulation / Transcription Inhibitor Technical Notes * PubChem Name: CID 5967294 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) IL-3 9ng/ml R08 exp493 https://crispr.tyerslab.com/wiki/results/exp493?rev=1767843420&do=diff IL-3 9ng/ml R08 exp493 Mechanism of Action Ligand for IL3RA receptor, induces myeloid lineage proliferation and differentiation * Class / Subclass 1: Signal Transduction / Receptor Ligand Technical Notes * PubChem Name: N/A * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Isoniazid 100μM R08 exp494 https://crispr.tyerslab.com/wiki/results/exp494?rev=1767843420&do=diff Isoniazid 100μM R08 exp494 Mechanism of Action Inhibits fatty acid synthases, pro-drug activated by catalase-peroxidase KatG * Class / Subclass 1: Infectious Disease / Antibiotic Technical Notes * PubChem Name: Isoniazid * Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) IWR1 50μM R08 exp495 https://crispr.tyerslab.com/wiki/results/exp495?rev=1767843420&do=diff IWR1 50μM R08 exp495 Mechanism of Action Stabilizes axin complex, inhibits Wnt/β-catenin signaling, also inhibits tankyrase * Class / Subclass 1: Signal Transduction / Other Inhibitor Technical Notes * PubChem Name: IWR-1-endo * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Lead acetate 990μM R08 exp496 https://crispr.tyerslab.com/wiki/results/exp496?rev=1767843420&do=diff Lead acetate 990μM R08 exp496 Mechanism of Action Industrial pollutant, heavy metal toxin * Class / Subclass 1: Environmental Stresses / Heavy Metal Technical Notes * PubChem Name: Lead acetate trihydrate * Synonyms: N/A * CAS #: 6080-56-4 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Lead acetate 2000μM R08 exp497 https://crispr.tyerslab.com/wiki/results/exp497?rev=1767843420&do=diff Lead acetate 2000μM R08 exp497 Mechanism of Action Industrial pollutant, heavy metal toxin * Class / Subclass 1: Environmental Stresses / Heavy Metal Technical Notes * PubChem Name: Lead acetate trihydrate * Synonyms: N/A * CAS #: 6080-56-4 text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Lead acetate 2000μM R08 exp498 no dilution day6 https://crispr.tyerslab.com/wiki/results/exp498?rev=1767843420&do=diff Lead acetate 2000μM R08 exp498 no dilution day6 Mechanism of Action Industrial pollutant, heavy metal toxin * Class / Subclass 1: Environmental Stresses / Heavy Metal Technical Notes * PubChem Name: Lead acetate trihydrate * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LY2090314 0.003μM R08 exp499 https://crispr.tyerslab.com/wiki/results/exp499?rev=1767843420&do=diff LY2090314 0.003μM R08 exp499 Mechanism of Action Inhibits glycogen synthase kinase-3 (GSK-3), activates Wnt signalling * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 3-[6-Fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) LY2090314 0.003μM R08 exp500 no dilution day6 https://crispr.tyerslab.com/wiki/results/exp500?rev=1767843420&do=diff LY2090314 0.003μM R08 exp500 no dilution day6 Mechanism of Action Inhibits glycogen synthase kinase-3 (GSK-3), activates Wnt signalling * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: 3-[6-Fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Methotrexate 0.01μM R08 exp501 https://crispr.tyerslab.com/wiki/results/exp501?rev=1767843420&do=diff Methotrexate 0.01μM R08 exp501 Mechanism of Action Inhibits dihydrofolate reductase (DHFR) * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor Technical Notes * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Milciclib 2μM R08 exp502 https://crispr.tyerslab.com/wiki/results/exp502?rev=1767843420&do=diff Milciclib 2μM R08 exp502 Mechanism of Action Inhibits CDK2, also TRKA, CDK1, CDK4 * Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Mitomycin-C 0.06μM R08 exp503 https://crispr.tyerslab.com/wiki/results/exp503?rev=1767843420&do=diff Mitomycin-C 0.06μM R08 exp503 Mechanism of Action DNA crosslinker, reductive activation forms a mitosene that N-alkylates successively DNA bases * Class / Subclass 1: DNA Damage, Repair and Replication / Inter/Intra-strand Crosslinker Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) MK2206 4μM R08 exp504 https://crispr.tyerslab.com/wiki/results/exp504?rev=1767843420&do=diff MK2206 4μM R08 exp504 Mechanism of Action Inhibit Akt1, Akt2, Akt3 * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: MK-2206 dihydrochloride * Synonyms: N/A * CAS #: 1032350-13-2 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ML-792 0.2μM R08 exp505 https://crispr.tyerslab.com/wiki/results/exp505?rev=1767843420&do=diff ML-792 0.2μM R08 exp505 Mechanism of Action Inhibits SUMO-activating enzyme (SAE) * Class / Subclass 1: Proteostasis / SUMOylation Inhibitor Technical Notes * PubChem Name: [(1R,2S,4R)-4-[[5-[1-[(3-Bromophenyl)methyl]pyrazole-3-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Momordin-Ic 10μM R08 exp506 https://crispr.tyerslab.com/wiki/results/exp506?rev=1767843420&do=diff Momordin-Ic 10μM R08 exp506 Mechanism of Action Triterpenoid saponin, putative SUMO-specific protease 1 (SENP1) inhibitor * Class / Subclass 1: Uncharacterized Mechanism / Traditional Medicine * Class / Subclass 2: Proteostasis / SUMOylation Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Monensin 0.3μM R08 exp507 https://crispr.tyerslab.com/wiki/results/exp507?rev=1767843420&do=diff Monensin 0.3μM R08 exp507 Mechanism of Action Polyether antibiotic, binds monovalent cations, Na+/H+ antiporter, blocks Golgi transport * Class / Subclass 1: Infectious Disease / Antibiotic * Class / Subclass 2: Organelle Function / Membrane Ionophore text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) NN-Dimethylsphingosine 2.5μM R08 exp508 https://crispr.tyerslab.com/wiki/results/exp508?rev=1767843420&do=diff NN-Dimethylsphingosine 2.5μM R08 exp508 Mechanism of Action Inhibits sphingosine kinase, blocks sphingosine 1-phosphate (SPP) formation * Class / Subclass 1: Metabolism / Metabolite * Class / Subclass 2: Signal Transduction / Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Nicotine 3000μM R08 exp510 https://crispr.tyerslab.com/wiki/results/exp510?rev=1767843420&do=diff Nicotine 3000μM R08 exp510 Mechanism of Action Agonist for nicotinic acetylcholine receptors (nAChRs) * Class / Subclass 1: Environmental Stresses / Psychoactive Drug * Class / Subclass 2: Signal Transduction / Other Receptor Agonist Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Olaparib 4μM R08 exp512 https://crispr.tyerslab.com/wiki/results/exp512?rev=1767843420&do=diff Olaparib 4μM R08 exp512 Mechanism of Action Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers * Class / Subclass 1: DNA Damage, Repair and Replication / PARP Inhibitor Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ONC212 0.15μM R08 exp513 https://crispr.tyerslab.com/wiki/results/exp513?rev=1767843420&do=diff ONC212 0.15μM R08 exp513 Mechanism of Action Inhibits mitochondrial CLPP protease, more potent derivative of TIC10/ONC201, possible agonist of GPR132 * Class / Subclass 1: Proteostasis / Protease Inhibitor * Class / Subclass 2: Signal Transduction / GPCR Agonist text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Phorbol-12-myristate-13-acetate 0.57μM R08 exp514 https://crispr.tyerslab.com/wiki/results/exp514?rev=1767843420&do=diff Phorbol-12-myristate-13-acetate 0.57μM R08 exp514 Mechanism of Action Activates PKC isoforms, potent tumour promoter * Class / Subclass 1: Signal Transduction / Kinase Activator Technical Notes * PubChem Name: Phorbol 12-myristate 13-acetate text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) PU-H71 1μM R08 exp515 https://crispr.tyerslab.com/wiki/results/exp515?rev=1767843420&do=diff PU-H71 1μM R08 exp515 Mechanism of Action Inhibits HSP90 * Class / Subclass 1: Proteostasis / Chaperone Inhibitor Technical Notes * PubChem Name: 9H-Purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)- * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Pyrazinamide 100μM R08 exp516 https://crispr.tyerslab.com/wiki/results/exp516?rev=1767843420&do=diff Pyrazinamide 100μM R08 exp516 Mechanism of Action Inhibits growth of Mycobacterium tuberculosis in combination with isoniazid, ethambutanol and rifampicin, converted to active pyrazinamide by pyrazinamidase * Class / Subclass 1: Infectious Disease / Antibiotic text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Quercetin 20μM R08 exp517 https://crispr.tyerslab.com/wiki/results/exp517?rev=1767843420&do=diff Quercetin 20μM R08 exp517 Mechanism of Action General kinase inhibitor, may inhibit NF-‘_B, anti-oxidant, putative senolytic * Class / Subclass 1: Signal Transduction / Kinase Inhibitor * Class / Subclass 2: Gene Regulation / Transcription Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) RK-33 8μM R08 exp518 https://crispr.tyerslab.com/wiki/results/exp518?rev=1767843420&do=diff RK-33 8μM R08 exp518 Mechanism of Action Inhibits DDX3 RNA helicase, causes G1 arrest and apoptosis, broad spectrum anti-viral * Class / Subclass 1: Proteostasis / Translation Inhibitor * Class / Subclass 2: Infectious Disease / Antiviral Technical Notes text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) RS-1 10μM R08 exp519 https://crispr.tyerslab.com/wiki/results/exp519?rev=1767843420&do=diff RS-1 10μM R08 exp519 Mechanism of Action Activates DNA binding by RAD51 * Class / Subclass 1: DNA Damage, Repair and Replication / Repair Protein Activator Technical Notes * PubChem Name: 3-(Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Rucaparib 6.5μM R08 exp520 https://crispr.tyerslab.com/wiki/results/exp520?rev=1767843420&do=diff Rucaparib 6.5μM R08 exp520 Mechanism of Action PARP1/2/3 inhibitor (Clovis), PARP1 mediates single-strand break repair, which can lead to replication-induced double strand breaks to form if not repaired; specifically target cancer with BRCA1, BRCA2 or PALB2 mutations; FDA granted an accelerated approval for use in cases of pretreated advanced ovarian cancer text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Salinomycin 3.5μM R08 exp521 https://crispr.tyerslab.com/wiki/results/exp521?rev=1767843420&do=diff Salinomycin 3.5μM R08 exp521 Mechanism of Action Potassium ionophore antibiotic, has activity against cancer stem cells * Class / Subclass 1: Organelle Function / Membrane Ionophore Technical Notes * PubChem Name: Salinomycin * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Staurosporine 0.02μM R08 exp524 https://crispr.tyerslab.com/wiki/results/exp524?rev=1767843420&do=diff Staurosporine 0.02μM R08 exp524 Mechanism of Action Inhibits many protein kinases including PKC, PKA, tyrosine kinases, CDKs, others * Class / Subclass 1: Signal Transduction / Kinase Inhibitor Technical Notes * PubChem Name: Staurosporine text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Sulforaphane 9μM R08 exp525 https://crispr.tyerslab.com/wiki/results/exp525?rev=1767843420&do=diff Sulforaphane 9μM R08 exp525 Mechanism of Action Organosulfur compound, found in cruciferous plants * Class / Subclass 1: Uncharacterized Mechanism / Natural Product Technical Notes * PubChem Name: Sulforaphane * Synonyms: N/A * CAS #: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Sulforaphane 9μM R08 exp526 no dilution day6 https://crispr.tyerslab.com/wiki/results/exp526?rev=1767843420&do=diff Sulforaphane 9μM R08 exp526 no dilution day6 Mechanism of Action Organosulfur compound, found in cruciferous plants * Class / Subclass 1: Uncharacterized Mechanism / Natural Product Technical Notes * PubChem Name: Sulforaphane * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Tanespimycin 14μM R08 exp527 https://crispr.tyerslab.com/wiki/results/exp527?rev=1767843420&do=diff Tanespimycin 14μM R08 exp527 Mechanism of Action Inhibits HSP90, derivative of geldanamycin, a.k.a 17-AAG * Class / Subclass 1: Proteostasis / Chaperone Inhibitor * Class / Subclass 2: Infectious Disease / Antibiotic Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) TGF-beta1 44ng/ml R08 exp528 https://crispr.tyerslab.com/wiki/results/exp528?rev=1767843420&do=diff TGF-beta1 44ng/ml R08 exp528 Mechanism of Action Ligand for TGF-β1 receptor * Class / Subclass 1: Signal Transduction / Other Receptor Agonist Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: N/A * text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Thimerosal 0.85μM R08 exp529 https://crispr.tyerslab.com/wiki/results/exp529?rev=1767843420&do=diff Thimerosal 0.85μM R08 exp529 Mechanism of Action Organomercury compound, antiseptic and antifungal, approved preservative in vaccines * Class / Subclass 1: Infectious Disease / Antifungal Technical Notes * PubChem Name: Thimerosal * Synonyms: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Thioridazine 5μM R08 exp530 https://crispr.tyerslab.com/wiki/results/exp530?rev=1767843420&do=diff Thioridazine 5μM R08 exp530 Mechanism of Action DRD2/4 selectivity, causes cardiac arrhythmia, also has antibiotic activity against M. tuberculosis * Class / Subclass 1: Signal Transduction / GPCR Antagonist Technical Notes * PubChem Name: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) THZ1 0.06μM R08 exp531 https://crispr.tyerslab.com/wiki/results/exp531?rev=1767843420&do=diff THZ1 0.06μM R08 exp531 Mechanism of Action Inhibits CDK7, forms covalent adduct, blocks phosphorylation of the C-terminal domain of RNA polymerase II * Class / Subclass 1: Gene Regulation / Transcription Inhibitor * Class / Subclass 2: Signal Transduction / Kinase Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) TIC10 10μM R08 exp532 https://crispr.tyerslab.com/wiki/results/exp532?rev=1767843420&do=diff TIC10 10μM R08 exp532 Mechanism of Action Inhibits mitochondrial CLPP protease, a.k.a. ONC201, parent of ONC212, possible agonist of GPR132 * Class / Subclass 1: Proteostasis / Protease Inhibitor * Class / Subclass 2: Signal Transduction / GPCR Agonist text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) TNF-alpha 44ng/ml R08 exp533 https://crispr.tyerslab.com/wiki/results/exp533?rev=1767843420&do=diff TNF-alpha 44ng/ml R08 exp533 Mechanism of Action Ligand for TNFR1, induces apoptosis or necrosis * Class / Subclass 1: Signal Transduction / Other Receptor Agonist Technical Notes * PubChem Name: N/A * Synonyms: N/A * CAS #: N/A * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Trientine 500μM R08 exp534 https://crispr.tyerslab.com/wiki/results/exp534?rev=1767843420&do=diff Trientine 500μM R08 exp534 Mechanism of Action Copper-selective chelator, enhances renal excretion of copper * Class / Subclass 1: Environmental Stresses / Metal Chelator Technical Notes * PubChem Name: Triethylenetetramine * Synonyms: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Trimetrexate 0.03μM R08 exp535 https://crispr.tyerslab.com/wiki/results/exp535?rev=1767843420&do=diff Trimetrexate 0.03μM R08 exp535 Mechanism of Action Inhibits bacterial, protozoan, and mammalian dihydrofolate reductase (DHFR), methotrexate analog * Class / Subclass 1: Metabolism / Antimetabolite * Class / Subclass 2: DNA Damage, Repair and Replication / Replication Inhibitor text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) Vitamin-D3 40μM R08 exp536 https://crispr.tyerslab.com/wiki/results/exp536?rev=1767843420&do=diff Vitamin-D3 40μM R08 exp536 Mechanism of Action Steroid hormone, converted to active 1,25-dihydroxycholecalciferol (calcitriol), role in calcium homeostasis * Class / Subclass 1: Metabolism / Vitamin * Class / Subclass 2: Metabolism / Metabolite text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) WNT3A 44ng/ml R08 exp537 https://crispr.tyerslab.com/wiki/results/exp537?rev=1767843420&do=diff WNT3A 44ng/ml R08 exp537 Mechanism of Action Ligand for Frizzled receptor complex, stabilizes ‘_-catenin, induces TCS/LEF-dependent transcription * Class / Subclass 1: Signal Transduction / GPCR Agonist Technical Notes * PubChem Name: N/A text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) ZLN024 50μM R08 exp538 https://crispr.tyerslab.com/wiki/results/exp538?rev=1767843420&do=diff ZLN024 50μM R08 exp538 Mechanism of Action Activates AMPK, allosteric * Class / Subclass 1: Signal Transduction / Kinase Activator Technical Notes * PubChem Name: ZLN024 hydrochloride * Synonyms: N/A * CAS #: 1883548-91-1 * PubChem CID: text/html 2026-01-08T03:37:00+00:00 Anonymous (anonymous@undisclosed.example.com) 42°C R08 exp539 https://crispr.tyerslab.com/wiki/results/exp539?rev=1767843420&do=diff 42°C R08 exp539 Mechanism of Action Elevated growth temperature * Class / Subclass 1: Environmental Stresses / Stress Condition Screen Summary * Round: 08 * Dose: N/A * Days of incubation: 8 * Doublings: -0.5 * Numbers of reads: 18691098