AAMP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= AAMP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AAMP
  * **<color #00a2e8>Official Name</color>**: angio associated migratory cell protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=14|14]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13685|Q13685]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AAMP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AAMP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603488|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. {ECO:0000269|PubMed:10329261, ECO:0000269|PubMed:18634987}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle cell migration|
|muscle cell migration|
|intercellular bridge|
|ribosomal large subunit biogenesis|
|positive regulation of endothelial cell migration|
|unfolded protein binding|
|positive regulation of epithelial cell migration|
|microtubule cytoskeleton|
|regulation of endothelial cell migration|
|heparin binding|
|regulation of epithelial cell migration|
|ribosome biogenesis|
|angiogenesis|
|blood vessel morphogenesis|
|ribonucleoprotein complex biogenesis|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell surface|
|tube morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|localization of cell|
|cell motility|
|locomotion|
|movement of cell or subcellular component|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.42|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.93|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.71|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.72|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.74|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.85|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.86|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.87|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.87|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.92|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.93|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.93|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.99|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.19|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.23|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|2.53|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|3.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.589|
|[[:human genes:n:npipb5|NPIPB5]]|0.57|
|[[:human genes:p:psmb4|PSMB4]]|0.55|
|[[:human genes:t:tceb3c|TCEB3C]]|0.545|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.542|
|[[:human genes:v:vasn|VASN]]|0.539|
|[[:human genes:c:c14orf93|C14orf93]]|0.528|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.519|
|[[:human genes:n:nupl1|NUPL1]]|0.518|
|[[:human genes:d:dtl|DTL]]|0.517|
|[[:human genes:s:sap30bp|SAP30BP]]|0.514|
|[[:human genes:c:cdh24|CDH24]]|0.51|
|[[:human genes:c:copg1|COPG1]]|0.51|
|[[:human genes:c:cbwd3|CBWD3]]|0.508|
|[[:human genes:r:rps2|RPS2]]|0.506|
|[[:human genes:u:utp3|UTP3]]|0.501|
|[[:human genes:s:sf3a1|SF3A1]]|0.498|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.498|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.497|
|[[:human genes:p:psmd11|PSMD11]]|0.496|
|[[:human genes:i:ik|IK]]|0.495|
|[[:human genes:t:tpx2|TPX2]]|0.494|
|[[:human genes:r:ranbp2|RANBP2]]|0.493|
|[[:human genes:o:orc1|ORC1]]|0.493|
|[[:human genes:c:copb1|COPB1]]|0.492|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.491|
|[[:human genes:p:psmc2|PSMC2]]|0.49|
|[[:human genes:e:eif4a3|EIF4A3]]|0.486|
|[[:human genes:c:cbwd6|CBWD6]]|0.485|
|[[:human genes:p:pan3|PAN3]]|0.484|
|[[:human genes:t:ticrr|TICRR]]|0.48|
|[[:human genes:a:arcn1|ARCN1]]|0.479|
|[[:human genes:n:nop16|NOP16]]|0.478|
|[[:human genes:d:disp2|DISP2]]|0.478|
|[[:human genes:s:supt5h|SUPT5H]]|0.477|
|[[:human genes:s:supt6h|SUPT6H]]|0.476|
|[[:human genes:n:nol10|NOL10]]|0.475|
|[[:human genes:c:cln6|CLN6]]|0.475|
|[[:human genes:g:gosr2|GOSR2]]|0.475|
|[[:human genes:c:cbwd5|CBWD5]]|0.473|
|[[:human genes:a:aqr|AQR]]|0.473|
|[[:human genes:p:pole|POLE]]|0.472|
|[[:human genes:n:napa|NAPA]]|0.471|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.469|
|[[:human genes:c:copa|COPA]]|0.469|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.469|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.468|
|[[:human genes:p:polr2f|POLR2F]]|0.468|
|[[:human genes:c:cep192|CEP192]]|0.468|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.468|
|[[:human genes:s:slc6a17|SLC6A17]]|0.465|
|[[:human genes:r:rpl12|RPL12]]|0.464|
|[[:human genes:m:myb|MYB]]|0.463|
|[[:human genes:o:or10g3|OR10G3]]|0.462|
|[[:human genes:k:kpnb1|KPNB1]]|0.462|
|[[:human genes:p:psma6|PSMA6]]|0.462|
|[[:human genes:d:dock6|DOCK6]]|0.461|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.461|
|[[:human genes:g:golga8o|GOLGA8O]]|0.46|
|[[:human genes:g:golga6a|GOLGA6A]]|0.46|
|[[:human genes:o:orc6|ORC6]]|0.46|
|[[:human genes:t:twistnb|TWISTNB]]|0.46|
|[[:human genes:n:numa1|NUMA1]]|0.458|
|[[:human genes:s:slc4a1|SLC4A1]]|0.457|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.456|
|[[:human genes:t:timeless|TIMELESS]]|0.455|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.455|
|[[:human genes:c:ccna2|CCNA2]]|0.454|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.454|
|[[:human genes:m:mt1e|MT1E]]|0.454|
|[[:human genes:r:rps19|RPS19]]|0.453|
|[[:human genes:d:ddt|DDT]]|0.452|
|[[:human genes:n:narfl|NARFL]]|0.452|
|[[:human genes:r:rrp1|RRP1]]|0.452|
|[[:human genes:n:ncapg|NCAPG]]|0.451|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.451|
|[[:human genes:p:pola2|POLA2]]|0.45|
|[[:human genes:a:atxn1|ATXN1]]|0.45|
|[[:human genes:c:col2a1|COL2A1]]|0.45|
|[[:human genes:h:hinfp|HINFP]]|0.449|
|[[:human genes:p:psmd14|PSMD14]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.448|
|[[:human genes:r:rrs1|RRS1]]|0.448|
|[[:human genes:e:exosc6|EXOSC6]]|0.448|
|[[:human genes:t:tspy8|TSPY8]]|0.448|
|[[:human genes:n:nup160|NUP160]]|0.448|
|[[:human genes:p:paf1|PAF1]]|0.446|
|[[:human genes:s:snrpa1|SNRPA1]]|0.445|
|[[:human genes:z:znf655|ZNF655]]|0.444|
|[[:human genes:v:vps54|VPS54]]|0.444|
|[[:human genes:a:akt1s1|AKT1S1]]|0.444|
|[[:human genes:p:ppfia4|PPFIA4]]|0.444|
|[[:human genes:d:ddtl|DDTL]]|0.444|
|[[:human genes:z:znf830|ZNF830]]|0.444|
|[[:human genes:m:mylk3|MYLK3]]|0.443|
|[[:human genes:m:med14|MED14]]|0.443|
|[[:human genes:a:ankle1|ANKLE1]]|0.443|
|[[:human genes:k:kctd17|KCTD17]]|0.443|
|[[:human genes:l:lrr1|LRR1]]|0.443|
|[[:human genes:k:kif3c|KIF3C]]|0.442|
|[[:human genes:r:rad51|RAD51]]|0.441|
|[[:human genes:c:cope|COPE]]|0.441|
|[[:human genes:z:znf106|ZNF106]]|0.441|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.44|
|[[:human genes:x:xylt2|XYLT2]]|0.437|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.437|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.437|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.437|
|[[:human genes:c:chaf1a|CHAF1A]]|0.436|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.436|
|[[:human genes:s:sec13|SEC13]]|0.436|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.436|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.435|
|[[:human genes:s:snip1|SNIP1]]|0.435|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.434|
|[[:human genes:p:pno1|PNO1]]|0.434|
|[[:human genes:r:rbm39|RBM39]]|0.432|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.431|
|[[:human genes:p:psma7|PSMA7]]|0.43|
|[[:human genes:a:ankle2|ANKLE2]]|0.43|
|[[:human genes:r:rpl35|RPL35]]|0.43|
|[[:human genes:r:rps7|RPS7]]|0.428|
|[[:human genes:e:exd1|EXD1]]|0.427|
|[[:human genes:l:lad1|LAD1]]|0.427|
|[[:human genes:c:cdca3|CDCA3]]|0.426|
|[[:human genes:i:igfn1|IGFN1]]|0.425|
|[[:human genes:p:polr1a|POLR1A]]|0.425|
|[[:human genes:r:rrp7a|RRP7A]]|0.425|
|[[:human genes:r:rbbp5|RBBP5]]|0.424|
|[[:human genes:c:cactin|CACTIN]]|0.424|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.424|
|[[:human genes:v:vps28|VPS28]]|0.423|
|[[:human genes:a:akirin2|AKIRIN2]]|0.423|
|[[:human genes:e:egr2|EGR2]]|0.423|
|[[:human genes:r:rffl|RFFL]]|0.422|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.422|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.422|
|[[:human genes:p:psmd2|PSMD2]]|0.422|
|[[:human genes:b:brd2|BRD2]]|0.422|
|[[:human genes:g:gar1|GAR1]]|0.422|
|[[:human genes:t:tfip11|TFIP11]]|0.422|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.421|
|[[:human genes:n:nup133|NUP133]]|0.42|
|[[:human genes:i:ints5|INTS5]]|0.42|
|[[:human genes:e:exosc5|EXOSC5]]|0.419|
|[[:human genes:p:prim1|PRIM1]]|0.419|
|[[:human genes:s:stil|STIL]]|0.418|
|[[:human genes:p:pola1|POLA1]]|0.417|
|[[:human genes:m:mfsd12|MFSD12]]|0.416|
|[[:human genes:a:acsf2|ACSF2]]|0.415|
|[[:human genes:k:krt2|KRT2]]|0.415|
|[[:human genes:i:ints1|INTS1]]|0.415|
|[[:human genes:r:rrp15|RRP15]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:p:pan2|PAN2]]|0.414|
|[[:human genes:t:tsg101|TSG101]]|0.414|
|[[:human genes:t:tuba8|TUBA8]]|0.414|
|[[:human genes:r:rpl6|RPL6]]|0.413|
|[[:human genes:m:myt1l|MYT1L]]|0.413|
|[[:human genes:a:abhd8|ABHD8]]|0.411|
|[[:human genes:c:c3orf17|C3orf17]]|0.411|
|[[:human genes:c:copb2|COPB2]]|0.411|
|[[:human genes:f:fcn2|FCN2]]|0.411|
|[[:human genes:t:taf1|TAF1]]|0.41|
|[[:human genes:r:rps12|RPS12]]|0.41|
|[[:human genes:r:rps9|RPS9]]|0.409|
|[[:human genes:m:mcoln1|MCOLN1]]|0.409|
|[[:human genes:f:fam231c|FAM231C]]|0.409|
|[[:human genes:n:nsf|NSF]]|0.408|
|[[:human genes:f:fam231a|FAM231A]]|0.408|
|[[:human genes:n:ndc80|NDC80]]|0.407|
|[[:human genes:s:snx15|SNX15]]|0.407|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:r:rrn3|RRN3]]|0.406|
|[[:human genes:c:cwc22|CWC22]]|0.406|
|[[:human genes:c:ctr9|CTR9]]|0.404|
|[[:human genes:z:znf574|ZNF574]]|0.404|
|[[:human genes:p:psmd6|PSMD6]]|0.403|
|[[:human genes:s:snrnp200|SNRNP200]]|0.402|
|[[:human genes:m:med15|MED15]]|0.402|
|[[:human genes:p:parp3|PARP3]]|0.402|
|[[:human genes:g:gprin2|GPRIN2]]|0.401|
|[[:human genes:m:myo1h|MYO1H]]|0.401|
|[[:human genes:s:s1pr4|S1PR4]]|0.401|
|[[:human genes:s:sprr2b|SPRR2B]]|0.401|
|[[:human genes:r:rpl9|RPL9]]|0.401|
|[[:human genes:r:rnpc3|RNPC3]]|0.401|
|[[:human genes:f:fam160a1|FAM160A1]]|0.4|
|[[:human genes:n:nup153|NUP153]]|0.4|
|[[:human genes:a:aatf|AATF]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 117/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|4/28|
|bone|3/26|
|breast|3/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|6/21|
|liver|1/20|
|lung|8/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|7/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 538
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AAMP Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>