ABCE1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABCE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABCE1
  * **<color #00a2e8>Official Name</color>**: ATP binding cassette subfamily E member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6059|6059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61221|P61221]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABCE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABCE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ABC tran|
|Fer4|
|RLI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoribonuclease inhibitor activity|
|negative regulation of endoribonuclease activity|
|negative regulation of ribonuclease activity|
|regulation of endoribonuclease activity|
|negative regulation of nuclease activity|
|regulation of ribonuclease activity|
|ribosomal subunit export from nucleus|
|ribosome localization|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|ribosomal small subunit binding|
|regulation of nuclease activity|
|regulation of type I interferon-mediated signaling pathway|
|translational termination|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|iron ion binding|
|cellular protein complex disassembly|
|translational initiation|
|protein export from nucleus|
|nuclear export|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|RNA transport|
|defense response to virus|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|ATPase activity|
|nucleobase-containing compound transport|
|protein-containing complex disassembly|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|response to virus|
|ribosome biogenesis|
|establishment of organelle localization|
|mitochondrial matrix|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|regulation of response to biotic stimulus|
|amide biosynthetic process|
|peptide metabolic process|
|organelle localization|
|viral process|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|defense response to other organism|
|intracellular protein transport|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of immune response|
|mitochondrion|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.78|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.74|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 531/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|16/28|
|bone|19/26|
|breast|22/33|
|central nervous system|42/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|15/21|
|liver|13/20|
|lung|49/75|
|lymphocyte|14/16|
|ovary|19/26|
|pancreas|15/24|
|peripheral nervous system|10/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1183
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABCE1 Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>