ABHD17B [The Human Chemical-Genetic Interaction Map Project]

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======= ABHD17B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD17B
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 17B, depalmitoylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51104|51104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VST6|Q5VST6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD17B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD17B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). {ECO:0000250|UniProtKB:Q7M759, ECO:0000269|PubMed:26701913}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 5|
|Abhydrolase 6|
|Peptidase S9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|anchored component of postsynaptic recycling endosome membrane|
|anchored component of postsynaptic density membrane|
|negative regulation of protein localization to microtubule|
|regulation of protein localization to microtubule|
|protein depalmitoylation|
|palmitoyl-(protein) hydrolase activity|
|macromolecule depalmitoylation|
|positive regulation of protein localization to endosome|
|regulation of dendritic spine maintenance|
|regulation of protein localization to endosome|
|lipoprotein catabolic process|
|regulation of protein localization to synapse|
|protein palmitoylation|
|protein deacylation|
|macromolecule deacylation|
|recycling endosome membrane|
|protein lipidation|
|lipoprotein biosynthetic process|
|regulation of postsynapse organization|
|negative regulation of cellular protein localization|
|lipoprotein metabolic process|
|dendritic spine|
|protein acylation|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|positive regulation of cellular protein localization|
|glutamatergic synapse|
|regulation of cellular protein localization|
|cell junction|
|protein catabolic process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cellular localization|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.14|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.87|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.73|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.84|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD17B Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>