ABHD5 [The Human Chemical-Genetic Interaction Map Project]

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======= ABHD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD5
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51099|51099]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTS1|Q8WTS1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity). {ECO:0000250|UniProtKB:Q9DBL9, ECO:0000269|PubMed:16679289, ECO:0000269|PubMed:18606822, ECO:0000269|PubMed:18832586}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 6|
|Abhydrolase 5|
|Abhydrolase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lysophosphatidic acid acyltransferase activity|
|negative regulation of sequestering of triglyceride|
|positive regulation of triglyceride catabolic process|
|positive regulation of lipoprotein lipase activity|
|positive regulation of triglyceride lipase activity|
|regulation of sequestering of triglyceride|
|regulation of triglyceride catabolic process|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|negative regulation of lipid storage|
|positive regulation of triglyceride metabolic process|
|regulation of lipoprotein lipase activity|
|triglyceride lipase activity|
|positive regulation of lipid catabolic process|
|carboxylic ester hydrolase activity|
|regulation of triglyceride metabolic process|
|phosphatidic acid biosynthetic process|
|negative regulation of lipid localization|
|phosphatidic acid metabolic process|
|regulation of lipid storage|
|regulation of lipid catabolic process|
|positive regulation of lipase activity|
|lipid droplet|
|regulation of lipase activity|
|lipid homeostasis|
|regulation of lipid localization|
|positive regulation of lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|fatty acid metabolic process|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|positive regulation of catabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|homeostatic process|
|small molecule metabolic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.66|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.36|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.34|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.05|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.83|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.83|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.82|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.81|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.72|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.77|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.83|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.89|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.13|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.17|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9914
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD5 Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>