ABHD6 [The Human Chemical-Genetic Interaction Map Project]

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======= ABHD6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABHD6
  * **<color #00a2e8>Official Name</color>**: abhydrolase domain containing 6, acylglycerol lipase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57406|57406]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BV23|Q9BV23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABHD6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABHD6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616966|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ndr|
|Abhydrolase 1|
|Abhydrolase 6|
|Abhydrolase 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of endocannabinoid signaling pathway|
|lysobisphosphatidic acid metabolic process|
|monoacylglycerol catabolic process|
|monoacylglycerol metabolic process|
|acylglycerol lipase activity|
|alditol phosphate metabolic process|
|long-term synaptic depression|
|phospholipase activity|
|AMPA glutamate receptor complex|
|phospholipid catabolic process|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|integral component of postsynaptic membrane|
|negative regulation of cold-induced thermogenesis|
|glycerolipid catabolic process|
|negative regulation of synaptic transmission|
|GABA-ergic synapse|
|positive regulation of lipid biosynthetic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|mitochondrial membrane|
|late endosome membrane|
|organophosphate catabolic process|
|positive regulation of lipid metabolic process|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cold-induced thermogenesis|
|regulation of lipid biosynthetic process|
|regulation of synaptic plasticity|
|cellular lipid catabolic process|
|negative regulation of cell migration|
|negative regulation of cell motility|
|lipid catabolic process|
|lysosomal membrane|
|glycerophospholipid metabolic process|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|glutamatergic synapse|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell migration|
|organophosphate metabolic process|
|regulation of cell motility|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|carbohydrate derivative metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|mitochondrion|
|negative regulation of cell communication|
|negative regulation of signaling|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.87|
|[[:results:exp187|proTAME 5μM R04 exp187]]|4.9|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|5.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nceh1|NCEH1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABHD6 Expression in NALM6 Cells: 3.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>