ABL1 [The Human Chemical-Genetic Interaction Map Project]

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======= ABL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABL1
  * **<color #00a2e8>Official Name</color>**: ABL proto-oncogene 1, non-receptor tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25|25]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00519|P00519]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ABL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ABL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin- associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21- dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|Pkinase Tyr|
|SH3 1|
|Pkinase|
|F actin bind|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transitional stage B cell differentiation|
|transitional one stage B cell differentiation|
|positive regulation of actin filament binding|
|positive regulation of actin binding|
|actin filament branching|
|negative regulation of phospholipase C activity|
|activation of protein kinase C activity|
|regulation of actin filament binding|
|mitochondrial depolarization|
|regulation of actin binding|
|positive regulation of interleukin-2 secretion|
|positive regulation blood vessel branching|
|B-1 B cell homeostasis|
|microspike assembly|
|neuropilin signaling pathway|
|regulation of blood vessel branching|
|nicotinate-nucleotide adenylyltransferase activity|
|B cell proliferation involved in immune response|
|positive regulation of microtubule binding|
|activated T cell proliferation|
|supercoiled DNA binding|
|platelet-derived growth factor receptor-beta signaling pathway|
|regulation of interleukin-2 secretion|
|regulation of Cdc42 protein signal transduction|
|Bergmann glial cell differentiation|
|bubble DNA binding|
|positive regulation of interferon-gamma secretion|
|negative regulation of phospholipase activity|
|DNA damage induced protein phosphorylation|
|collateral sprouting|
|positive regulation of Wnt signaling pathway, planar cell polarity pathway|
|immature B cell differentiation|
|positive regulation of osteoblast proliferation|
|regulation of microtubule binding|
|regulation of interferon-gamma secretion|
|regulation of modification of synaptic structure|
|negative regulation of long-term synaptic potentiation|
|positive regulation of non-canonical Wnt signaling pathway|
|sequence-specific double-stranded DNA binding|
|regulation of Wnt signaling pathway, planar cell polarity pathway|
|four-way junction DNA binding|
|negative regulation of ubiquitin-protein transferase activity|
|negative regulation of lipase activity|
|negative regulation of cellular senescence|
|proline-rich region binding|
|neuropilin binding|
|positive regulation of actin cytoskeleton reorganization|
|positive regulation of cell migration involved in sprouting angiogenesis|
|regulation of osteoblast proliferation|
|mitogen-activated protein kinase binding|
|regulation of non-canonical Wnt signaling pathway|
|negative regulation of cell aging|
|B cell homeostasis|
|positive regulation of focal adhesion assembly|
|actin monomer binding|
|ephrin receptor binding|
|negative regulation of endothelial cell apoptotic process|
|positive regulation of interleukin-2 production|
|positive regulation of adherens junction organization|
|peptidyl-tyrosine autophosphorylation|
|positive regulation of cell junction assembly|
|platelet-derived growth factor receptor signaling pathway|
|spleen development|
|positive regulation of morphogenesis of an epithelium|
|mismatch repair|
|SH2 domain binding|
|positive regulation of substrate adhesion-dependent cell spreading|
|cerebellum morphogenesis|
|regulation of actin cytoskeleton reorganization|
|regulation of extracellular matrix organization|
|T cell proliferation|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|phosphotyrosine residue binding|
|positive regulation of release of sequestered calcium ion into cytosol|
|regulation of cellular senescence|
|hindbrain morphogenesis|
|B cell proliferation|
|negative regulation of epithelial cell apoptotic process|
|cell leading edge|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of long-term synaptic potentiation|
|neuroepithelial cell differentiation|
|B cell activation involved in immune response|
|thymus development|
|regulation of phospholipase C activity|
|non-membrane spanning protein tyrosine kinase activity|
|regulation of cell aging|
|negative regulation of BMP signaling pathway|
|alpha-beta T cell differentiation|
|epidermal growth factor receptor signaling pathway|
|regulation of endothelial cell apoptotic process|
|regulation of microtubule polymerization|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|regulation of ubiquitin-protein transferase activity|
|membrane depolarization|
|substrate adhesion-dependent cell spreading|
|regulation of substrate adhesion-dependent cell spreading|
|neuromuscular process controlling balance|
|protein kinase C binding|
|positive regulation of oxidoreductase activity|
|astrocyte differentiation|
|lymphocyte homeostasis|
|regulation of interleukin-2 production|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of blood vessel endothelial cell migration|
|syntaxin binding|
|regulation of morphogenesis of a branching structure|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|positive regulation of actin filament bundle assembly|
|alpha-beta T cell activation|
|manganese ion binding|
|positive regulation of interferon-gamma production|
|endothelial cell migration|
|negative regulation of ERK1 and ERK2 cascade|
|regulation of adherens junction organization|
|regulation of sprouting angiogenesis|
|leukocyte homeostasis|
|ERBB signaling pathway|
|cellular response to hydrogen peroxide|
|positive regulation of calcium ion transmembrane transport|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane potential|
|regulation of phospholipase activity|
|regulation of hematopoietic stem cell differentiation|
|negative regulation of protein ubiquitination|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of stress fiber assembly|
|regulation of epithelial cell apoptotic process|
|regulation of microtubule polymerization or depolymerization|
|kinase activity|
|negative regulation of protein modification by small protein conjugation or removal|
|postsynapse|
|epithelial cell migration|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|regulation of hematopoietic progenitor cell differentiation|
|cellular response to dopamine|
|response to dopamine|
|positive regulation of muscle cell differentiation|
|epithelium migration|
|protein tyrosine kinase activity|
|developmental cell growth|
|regulation of BMP signaling pathway|
|regulation of cell junction assembly|
|post-embryonic development|
|regulation of actomyosin structure organization|
|regulation of blood vessel endothelial cell migration|
|cell growth|
|neural tube closure|
|tube closure|
|positive regulation of neuron death|
|regulation of actin filament bundle assembly|
|tissue migration|
|integrin-mediated signaling pathway|
|positive regulation of protein binding|
|columnar/cuboidal epithelial cell differentiation|
|regulation of oxidoreductase activity|
|regulation of axon extension|
|primary neural tube formation|
|regulation of lipase activity|
|leukocyte proliferation|
|regulation of interferon-gamma production|
|regulation of calcium ion transport into cytosol|
|positive regulation of endothelial cell migration|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|cerebellum development|
|signal transduction in response to DNA damage|
|neural tube formation|
|response to monoamine|
|response to catecholamine|
|B cell differentiation|
|neuromuscular process|
|lymphocyte activation involved in immune response|
|regulation of extent of cell growth|
|regulation of establishment of planar polarity|
|metencephalon development|
|developmental growth involved in morphogenesis|
|regulation of cell-matrix adhesion|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stem cell differentiation|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of calcium ion transport|
|positive regulation of cell-substrate adhesion|
|embryonic epithelial tube formation|
|regulation of sequestering of calcium ion|
|B cell receptor signaling pathway|
|cellular response to ammonium ion|
|cellular response to reactive oxygen species|
|SH3 domain binding|
|epithelial tube formation|
|negative regulation of protein serine/threonine kinase activity|
|T cell differentiation|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|Fc-gamma receptor signaling pathway|
|positive regulation of epithelial cell migration|
|positive regulation of cation transmembrane transport|
|regulation of Rho protein signal transduction|
|peptidyl-tyrosine phosphorylation|
|morphogenesis of embryonic epithelium|
|cell cycle arrest|
|regulation of calcium ion transmembrane transport|
|tube formation|
|peptidyl-tyrosine modification|
|negative regulation of cellular response to growth factor stimulus|
|intrinsic apoptotic signaling pathway|
|positive regulation of mitotic cell cycle|
|hindbrain development|
|regulation of muscle cell differentiation|
|B cell activation|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of ion transmembrane transport|
|regulation of endothelial cell migration|
|neural tube development|
|positive regulation of angiogenesis|
|negative regulation of MAPK cascade|
|regulation of lymphocyte differentiation|
|glial cell differentiation|
|ameboidal-type cell migration|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|regulation of morphogenesis of an epithelium|
|regulation of cell size|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of axonogenesis|
|cellular response to lipopolysaccharide|
|response to ammonium ion|
|cell-substrate adhesion|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|protein autophosphorylation|
|response to reactive oxygen species|
|positive regulation of supramolecular fiber organization|
|homeostasis of number of cells|
|regulation of protein ubiquitination|
|positive regulation of transmembrane transport|
|actin filament binding|
|regulation of cytokine secretion|
|regulation of endocytosis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|cellular response to toxic substance|
|gliogenesis|
|magnesium ion binding|
|cellular response to biotic stimulus|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of response to DNA damage stimulus|
|regulation of protein binding|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of protein kinase activity|
|regulation of synapse structure or activity|
|regulation of protein modification by small protein conjugation or removal|
|T cell activation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|lymphocyte differentiation|
|protein kinase activity|
|nuclear membrane|
|actin filament organization|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|regulation of actin filament organization|
|process utilizing autophagic mechanism|
|autophagy|
|positive regulation of protein secretion|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|negative regulation of transferase activity|
|nuclear body|
|positive regulation of cytosolic calcium ion concentration|
|transcription coactivator activity|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|DNA conformation change|
|regulation of cell morphogenesis involved in differentiation|
|response to antibiotic|
|epithelial tube morphogenesis|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of T cell activation|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of developmental growth|
|phagocytosis|
|leukocyte differentiation|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of Wnt signaling pathway|
|axonogenesis|
|neuronal cell body|
|regulation of cellular component size|
|regulation of binding|
|positive regulation of cell cycle|
|lymphocyte activation|
|regulation of metal ion transport|
|response to oxidative stress|
|developmental growth|
|regulation of actin filament-based process|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|axon development|
|gland development|
|regulation of cell growth|
|dendrite|
|positive regulation of protein transport|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|regulation of neuron projection development|
|positive regulation of cell migration|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|DNA repair|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|endocytosis|
|cellular metal ion homeostasis|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|protein-containing complex|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|immune system development|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|import into cell|
|epithelial cell differentiation|
|regulation of cell adhesion|
|mitotic cell cycle|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|cellular response to DNA damage stimulus|
|head development|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|response to lipid|
|nucleolus|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|immune effector process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|DNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ABL1 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>