ACACA [The Human Chemical-Genetic Interaction Map Project]

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======= ACACA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACACA
  * **<color #00a2e8>Official Name</color>**: acetyl-CoA carboxylase alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=31|31]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13085|Q13085]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACACA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACACA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/200350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Carboxyl trans|
|CPSase L chain|
|CPSase L D2|
|ACC central|
|Biotin lipoyl|
|Dala Dala lig C|
|Biotin carb C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetyl-CoA carboxylase activity|
|malonyl-CoA biosynthetic process|
|biotin carboxylase activity|
|malonyl-CoA metabolic process|
|carnitine shuttle|
|fatty acid transmembrane transport|
|cellular response to prostaglandin E stimulus|
|cellular response to prostaglandin stimulus|
|response to prostaglandin E|
|acetyl-CoA metabolic process|
|response to prostaglandin|
|fatty-acyl-CoA biosynthetic process|
|intracellular lipid transport|
|fatty-acyl-CoA metabolic process|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|thioester biosynthetic process|
|acyl-CoA biosynthetic process|
|cellular response to fatty acid|
|regulation of cholesterol metabolic process|
|long-chain fatty acid transport|
|ribonucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|fatty acid transport|
|regulation of alcohol biosynthetic process|
|cellular response to alcohol|
|response to fatty acid|
|regulation of steroid biosynthetic process|
|cellular response to ketone|
|fatty acid derivative biosynthetic process|
|protein homotetramerization|
|mitochondrial transmembrane transport|
|thioester metabolic process|
|acyl-CoA metabolic process|
|regulation of steroid metabolic process|
|fatty acid biosynthetic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|purine nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|fibrillar center|
|lipid homeostasis|
|coenzyme biosynthetic process|
|monocarboxylic acid transport|
|purine ribonucleotide biosynthetic process|
|protein tetramerization|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|tissue homeostasis|
|response to ketone|
|cellular response to acid chemical|
|cofactor biosynthetic process|
|mitochondrial transport|
|actin cytoskeleton|
|response to alcohol|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|purine ribonucleotide metabolic process|
|lipid localization|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|protein homooligomerization|
|anatomical structure homeostasis|
|response to acid chemical|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|protein complex oligomerization|
|cellular response to lipid|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|cellular response to hormone stimulus|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|response to lipid|
|organophosphate metabolic process|
|response to hormone|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|intracellular transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|small molecule metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.53|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.4|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.33|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.32|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.3|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.2|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.19|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.18|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.14|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.05|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.02|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.94|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.89|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.83|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.78|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.73|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.72|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.71|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.7|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.21|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.28|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.47|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.67|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.82|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.17|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.47|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|4.27|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|4.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mid1ip1|MID1IP1]]|0.485|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2977
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACACA Expression in NALM6 Cells: 8.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>