ACER1 [The Human Chemical-Genetic Interaction Map Project]

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======= ACER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACER1
  * **<color #00a2e8>Official Name</color>**: alkaline ceramidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=125981|125981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDN7|Q8TDN7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613491|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ceramidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to alkaline pH|
|dihydroceramidase activity|
|ceramidase activity|
|N-acylsphingosine amidohydrolase activity|
|sebaceous gland development|
|sphingosine biosynthetic process|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|sphingoid metabolic process|
|diol biosynthetic process|
|ceramide catabolic process|
|diol metabolic process|
|regulation of water loss via skin|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|response to pH|
|polyol biosynthetic process|
|multicellular organismal water homeostasis|
|water homeostasis|
|ceramide metabolic process|
|cellular response to calcium ion|
|sphingolipid biosynthetic process|
|polyol metabolic process|
|alcohol biosynthetic process|
|membrane lipid biosynthetic process|
|response to calcium ion|
|sphingolipid metabolic process|
|organic hydroxy compound biosynthetic process|
|cellular response to metal ion|
|ammonium ion metabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|cellular response to inorganic substance|
|keratinocyte differentiation|
|lipid catabolic process|
|epidermal cell differentiation|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|response to metal ion|
|skin development|
|regulation of lipid metabolic process|
|gland development|
|epidermis development|
|organic hydroxy compound metabolic process|
|regulation of body fluid levels|
|response to inorganic substance|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|epithelial cell differentiation|
|cellular amide metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.81|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.71|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8704
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACER1 Expression in NALM6 Cells: 0.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>