ACO1 [The Human Chemical-Genetic Interaction Map Project]

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======= ACO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACO1
  * **<color #00a2e8>Official Name</color>**: aconitase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=48|48]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21399|P21399]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/100880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aconitase|
|Aconitase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|iron-responsive element binding|
|aconitate hydratase activity|
|3 iron, 4 sulfur cluster binding|
|citrate metabolic process|
|response to iron(II) ion|
|tricarboxylic acid metabolic process|
|intestinal absorption|
|response to iron ion|
|tricarboxylic acid cycle|
|4 iron, 4 sulfur cluster binding|
|cellular iron ion homeostasis|
|digestive system process|
|aerobic respiration|
|iron ion homeostasis|
|post-embryonic development|
|antibiotic metabolic process|
|cellular transition metal ion homeostasis|
|digestion|
|transition metal ion homeostasis|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|regulation of translation|
|response to metal ion|
|regulation of cellular amide metabolic process|
|generation of precursor metabolites and energy|
|drug metabolic process|
|posttranscriptional regulation of gene expression|
|response to inorganic substance|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|Golgi apparatus|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|chemical homeostasis|
|mitochondrion|
|RNA binding|
|homeostatic process|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.483|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13262
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACO1 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>