ACOX2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACOX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACOX2
  * **<color #00a2e8>Official Name</color>**: acyl-CoA oxidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8309|8309]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99424|Q99424]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACOX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACOX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601641|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. {ECO:0000269|PubMed:27884763}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ACOX|
|Acyl-CoA dh M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|
|acyl-CoA oxidase activity|
|fatty acid beta-oxidation using acyl-CoA oxidase|
|positive regulation of response to oxidative stress|
|fatty acid binding|
|bile acid biosynthetic process|
|FAD binding|
|bile acid metabolic process|
|peroxisomal matrix|
|flavin adenine dinucleotide binding|
|fatty acid beta-oxidation|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|regulation of response to oxidative stress|
|fatty acid catabolic process|
|peroxisome|
|monocarboxylic acid catabolic process|
|steroid biosynthetic process|
|lipid homeostasis|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|cellular lipid catabolic process|
|lipid modification|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|protein targeting|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|protein localization to organelle|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of cell death|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14347
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACOX2 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>