ACSF2 [The Human Chemical-Genetic Interaction Map Project]

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======= ACSF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACSF2
  * **<color #00a2e8>Official Name</color>**: acyl-CoA synthetase family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80221|80221]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CM8|Q96CM8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACSF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACSF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation. {ECO:0000269|PubMed:16380219, ECO:0000269|PubMed:17762044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acyl-CoA ligase activity|
|acyl-CoA metabolic process|
|thioester metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.86|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.81|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.74|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.87|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.9|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.647|
|[[:human genes:r:rad51|RAD51]]|0.525|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.52|
|[[:human genes:c:cdc45|CDC45]]|0.511|
|[[:human genes:t:tfip11|TFIP11]]|0.509|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.506|
|[[:human genes:o:orc6|ORC6]]|0.504|
|[[:human genes:s:snrpa1|SNRPA1]]|0.498|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.498|
|[[:human genes:x:xylt2|XYLT2]]|0.495|
|[[:human genes:d:dtl|DTL]]|0.495|
|[[:human genes:s:slc4a1|SLC4A1]]|0.491|
|[[:human genes:c:ccna2|CCNA2]]|0.49|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.489|
|[[:human genes:p:psma6|PSMA6]]|0.489|
|[[:human genes:k:kctd17|KCTD17]]|0.488|
|[[:human genes:t:tceb3c|TCEB3C]]|0.487|
|[[:human genes:c:cactin|CACTIN]]|0.483|
|[[:human genes:p:psmc2|PSMC2]]|0.483|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.482|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.48|
|[[:human genes:p:psmb4|PSMB4]]|0.479|
|[[:human genes:u:utp3|UTP3]]|0.479|
|[[:human genes:s:supt5h|SUPT5H]]|0.477|
|[[:human genes:d:ddtl|DDTL]]|0.475|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.475|
|[[:human genes:m:mt1e|MT1E]]|0.473|
|[[:human genes:r:rpl35|RPL35]]|0.472|
|[[:human genes:n:nupl1|NUPL1]]|0.471|
|[[:human genes:r:rrn3|RRN3]]|0.471|
|[[:human genes:r:rps5|RPS5]]|0.47|
|[[:human genes:c:copg1|COPG1]]|0.468|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.465|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.464|
|[[:human genes:t:ticrr|TICRR]]|0.464|
|[[:human genes:d:dock6|DOCK6]]|0.461|
|[[:human genes:r:rrp7a|RRP7A]]|0.458|
|[[:human genes:n:nfatc4|NFATC4]]|0.458|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.458|
|[[:human genes:u:upf1|UPF1]]|0.457|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.456|
|[[:human genes:p:polr2l|POLR2L]]|0.455|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.455|
|[[:human genes:c:col2a1|COL2A1]]|0.454|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.453|
|[[:human genes:a:ankle1|ANKLE1]]|0.453|
|[[:human genes:i:ik|IK]]|0.453|
|[[:human genes:c:cebpz|CEBPZ]]|0.452|
|[[:human genes:a:ahctf1|AHCTF1]]|0.451|
|[[:human genes:p:pwp2|PWP2]]|0.451|
|[[:human genes:z:znf830|ZNF830]]|0.451|
|[[:human genes:c:cbwd3|CBWD3]]|0.449|
|[[:human genes:g:gar1|GAR1]]|0.448|
|[[:human genes:l:loc643669|LOC643669]]|0.448|
|[[:human genes:n:nipbl|NIPBL]]|0.447|
|[[:human genes:n:nsf|NSF]]|0.444|
|[[:human genes:c:cbwd5|CBWD5]]|0.444|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.443|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.443|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.443|
|[[:human genes:c:cdc73|CDC73]]|0.442|
|[[:human genes:f:fam160a1|FAM160A1]]|0.442|
|[[:human genes:p:psmb3|PSMB3]]|0.441|
|[[:human genes:c:chd4|CHD4]]|0.441|
|[[:human genes:v:vasn|VASN]]|0.441|
|[[:human genes:p:pole|POLE]]|0.44|
|[[:human genes:s:sec13|SEC13]]|0.439|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:t:tspy8|TSPY8]]|0.438|
|[[:human genes:n:nup160|NUP160]]|0.438|
|[[:human genes:m:myo1h|MYO1H]]|0.438|
|[[:human genes:a:ankle2|ANKLE2]]|0.435|
|[[:human genes:z:znf574|ZNF574]]|0.435|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.435|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.435|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.434|
|[[:human genes:a:atxn1|ATXN1]]|0.434|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.434|
|[[:human genes:d:dido1|DIDO1]]|0.434|
|[[:human genes:o:orc1|ORC1]]|0.433|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.433|
|[[:human genes:s:smg7|SMG7]]|0.432|
|[[:human genes:c:c14orf93|C14orf93]]|0.432|
|[[:human genes:p:psmc5|PSMC5]]|0.431|
|[[:human genes:c:cope|COPE]]|0.431|
|[[:human genes:z:znf655|ZNF655]]|0.431|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:p:psmc1|PSMC1]]|0.43|
|[[:human genes:c:cbwd6|CBWD6]]|0.429|
|[[:human genes:l:lrr1|LRR1]]|0.429|
|[[:human genes:u:ubap1|UBAP1]]|0.429|
|[[:human genes:r:rps9|RPS9]]|0.429|
|[[:human genes:n:narfl|NARFL]]|0.429|
|[[:human genes:w:wdr87|WDR87]]|0.429|
|[[:human genes:r:rps12|RPS12]]|0.429|
|[[:human genes:c:chmp2a|CHMP2A]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.428|
|[[:human genes:c:cdc6|CDC6]]|0.427|
|[[:human genes:d:ddx56|DDX56]]|0.427|
|[[:human genes:i:ints5|INTS5]]|0.426|
|[[:human genes:s:ssh2|SSH2]]|0.426|
|[[:human genes:r:rps2|RPS2]]|0.426|
|[[:human genes:s:sap30bp|SAP30BP]]|0.424|
|[[:human genes:z:zfand5|ZFAND5]]|0.424|
|[[:human genes:r:rpsa|RPSA]]|0.423|
|[[:human genes:o:osbp|OSBP]]|0.423|
|[[:human genes:p:psmd3|PSMD3]]|0.423|
|[[:human genes:i:iscu|ISCU]]|0.423|
|[[:human genes:g:golga8o|GOLGA8O]]|0.422|
|[[:human genes:i:ints6|INTS6]]|0.422|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.421|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.421|
|[[:human genes:s:stil|STIL]]|0.418|
|[[:human genes:t:tuba8|TUBA8]]|0.418|
|[[:human genes:p:pola2|POLA2]]|0.417|
|[[:human genes:c:copb1|COPB1]]|0.415|
|[[:human genes:r:rps28|RPS28]]|0.415|
|[[:human genes:a:aamp|AAMP]]|0.415|
|[[:human genes:c:chaf1a|CHAF1A]]|0.414|
|[[:human genes:t:twistnb|TWISTNB]]|0.413|
|[[:human genes:e:exosc5|EXOSC5]]|0.413|
|[[:human genes:v:vps54|VPS54]]|0.412|
|[[:human genes:c:ccdc116|CCDC116]]|0.412|
|[[:human genes:r:rrp15|RRP15]]|0.411|
|[[:human genes:g:golga6a|GOLGA6A]]|0.411|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.411|
|[[:human genes:r:rps3a|RPS3A]]|0.41|
|[[:human genes:p:psmd14|PSMD14]]|0.41|
|[[:human genes:o:ogfr|OGFR]]|0.41|
|[[:human genes:a:arcn1|ARCN1]]|0.409|
|[[:human genes:p:psmd11|PSMD11]]|0.408|
|[[:human genes:p:pola1|POLA1]]|0.408|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.408|
|[[:human genes:r:rpl9|RPL9]]|0.407|
|[[:human genes:c:ctage4|CTAGE4]]|0.407|
|[[:human genes:a:akirin2|AKIRIN2]]|0.405|
|[[:human genes:n:nol7|NOL7]]|0.405|
|[[:human genes:c:cln6|CLN6]]|0.404|
|[[:human genes:b:brd2|BRD2]]|0.404|
|[[:human genes:k:kif3c|KIF3C]]|0.404|
|[[:human genes:d:ddx47|DDX47]]|0.403|
|[[:human genes:p:psma7|PSMA7]]|0.403|
|[[:human genes:t:timeless|TIMELESS]]|0.402|
|[[:human genes:c:copa|COPA]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.402|
|[[:human genes:r:rps21|RPS21]]|0.401|
|[[:human genes:c:ckap5|CKAP5]]|0.401|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.4|
|[[:human genes:s:snx15|SNX15]]|0.4|
|[[:human genes:a:aqr|AQR]]|0.4|
|[[:human genes:r:rplp1|RPLP1]]|0.4|
|[[:human genes:p:psmd7|PSMD7]]|0.4|
|[[:human genes:h:hivep3|HIVEP3]]|0.4|
|[[:human genes:p:pan3|PAN3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACSF2 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>