ACTC1 [The Human Chemical-Genetic Interaction Map Project]

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======= ACTC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ACTC1
  * **<color #00a2e8>Official Name</color>**: actin alpha cardiac muscle 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=70|70]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68032|P68032]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ACTC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ACTC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Actin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actomyosin, actin portion|
|mesenchyme migration|
|skeletal muscle thin filament assembly|
|skeletal myofibril assembly|
|I band|
|myosin binding|
|cardiac myofibril assembly|
|muscle filament sliding|
|actin-myosin filament sliding|
|mesenchyme morphogenesis|
|sarcomere|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|cell body|
|filopodium|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|actin filament|
|muscle organ morphogenesis|
|heart contraction|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|tissue migration|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiocyte differentiation|
|response to ethanol|
|striated muscle cell development|
|blood microparticle|
|muscle cell development|
|cardiac muscle tissue development|
|lamellipodium|
|striated muscle cell differentiation|
|mesenchyme development|
|response to alcohol|
|ATPase activity|
|actin filament organization|
|muscle cell differentiation|
|muscle contraction|
|heart morphogenesis|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|response to antibiotic|
|glutamatergic synapse|
|blood circulation|
|circulatory system process|
|focal adhesion|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|response to toxic substance|
|heart development|
|tissue morphogenesis|
|actin filament-based process|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|negative regulation of cell death|
|response to drug|
|cytoskeleton organization|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|cell development|
|regulation of cell death|
|tissue development|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2.53|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.34|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.83|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.82|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.71|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.71|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:trmt10a|TRMT10A]]|0.426|
|[[:human genes:r:rptor|RPTOR]]|0.409|
|[[:human genes:e:eif3f|EIF3F]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7714
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ACTC1 Expression in NALM6 Cells: -0.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>