ADAM15 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAM15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAM15
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase domain 15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8751|8751]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13444|Q13444]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAM15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAM15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605548|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pep M12B propep|
|Disintegrin|
|ADAM CR|
|Reprolysin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immune response to tumor cell|
|response to hypobaric hypoxia|
|response to phorbol 13-acetate 12-myristate|
|cellular response to phorbol 13-acetate 12-myristate|
|response to tumor cell|
|negative regulation of receptor binding|
|regulation of receptor binding|
|cardiac epithelial to mesenchymal transition|
|negative regulation of cell-matrix adhesion|
|collagen catabolic process|
|negative regulation of cell-substrate adhesion|
|adherens junction|
|tissue regeneration|
|metallopeptidase activity|
|collagen metabolic process|
|extracellular matrix disassembly|
|epithelial to mesenchymal transition|
|cellular response to alcohol|
|acrosomal vesicle|
|cellular response to ketone|
|integrin-mediated signaling pathway|
|response to antineoplastic agent|
|motile cilium|
|negative regulation of protein binding|
|metalloendopeptidase activity|
|regulation of cell-matrix adhesion|
|cell-matrix adhesion|
|SH3 domain binding|
|integrin binding|
|male gonad development|
|development of primary male sexual characteristics|
|regeneration|
|male sex differentiation|
|mesenchymal cell differentiation|
|negative regulation of binding|
|negative regulation of cell growth|
|cell-substrate adhesion|
|response to ketone|
|gonad development|
|regulation of cell-substrate adhesion|
|development of primary sexual characteristics|
|regulation of protein binding|
|mesenchyme development|
|response to alcohol|
|negative regulation of growth|
|heart morphogenesis|
|negative regulation of cell migration|
|sex differentiation|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|angiogenesis|
|negative regulation of locomotion|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|regulation of binding|
|response to oxygen levels|
|extracellular structure organization|
|developmental growth|
|growth|
|cellular component disassembly|
|cellular response to drug|
|blood vessel morphogenesis|
|regulation of cell growth|
|reproductive structure development|
|reproductive system development|
|wound healing|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|response to wounding|
|cell surface|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|regulation of cell adhesion|
|innate immune response|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|negative regulation of molecular function|
|response to abiotic stimulus|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|tissue development|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.95|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.71|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3534
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAM15 Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>