ADAMTS18 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAMTS18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAMTS18
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase with thrombospondin type 1 motif 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=170692|170692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TE60|Q8TE60]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAMTS18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAMTS18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLAC|
|Pep M12B propep|
|ADAM spacer1|
|Reprolysin|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of platelet aggregation|
|negative regulation of homotypic cell-cell adhesion|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|regulation of homotypic cell-cell adhesion|
|regulation of platelet activation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|metalloendopeptidase activity|
|regulation of wound healing|
|regulation of response to wounding|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|negative regulation of cell adhesion|
|eye development|
|visual system development|
|negative regulation of response to external stimulus|
|sensory system development|
|regulation of cell-cell adhesion|
|regulation of body fluid levels|
|sensory organ development|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of response to stress|
|negative regulation of response to stimulus|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.72|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.74|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.79|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.88|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5449
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAMTS18 Expression in NALM6 Cells: 1.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>