ADAMTS9 [The Human Chemical-Genetic Interaction Map Project]

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======= ADAMTS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADAMTS9
  * **<color #00a2e8>Official Name</color>**: ADAM metallopeptidase with thrombospondin type 1 motif 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56999|56999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2N4|Q9P2N4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADAMTS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADAMTS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605421|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428- Glu-|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000269|PubMed:12514189, ECO:0000269|PubMed:22419820}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GON|
|TSP 1|
|Reprolysin|
|Pep M12B propep|
|ADAM spacer1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell-matrix adhesion|
|positive regulation of melanocyte differentiation|
|regulation of melanocyte differentiation|
|positive regulation of pigment cell differentiation|
|regulation of pigment cell differentiation|
|positive regulation of developmental pigmentation|
|regulation of developmental pigmentation|
|glycoprotein catabolic process|
|negative regulation of sprouting angiogenesis|
|aorta morphogenesis|
|negative regulation of endothelial cell migration|
|aorta development|
|heart valve morphogenesis|
|ventricular cardiac muscle tissue development|
|artery morphogenesis|
|heart valve development|
|metallopeptidase activity|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|artery development|
|negative regulation of angiogenesis|
|metalloendopeptidase activity|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|cell-matrix adhesion|
|regulation of endothelial cell migration|
|cardiac muscle tissue development|
|cell-substrate adhesion|
|carbohydrate derivative catabolic process|
|regulation of epithelial cell migration|
|extracellular matrix|
|negative regulation of cell migration|
|negative regulation of cell motility|
|striated muscle tissue development|
|regulation of angiogenesis|
|muscle tissue development|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|glycoprotein metabolic process|
|extracellular structure organization|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|cell surface|
|tube morphogenesis|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|response to bacterium|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|circulatory system development|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|negative regulation of multicellular organismal process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.73|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADAMTS9 Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>