ADCYAP1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ADCYAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADCYAP1
  * **<color #00a2e8>Official Name</color>**: adenylate cyclase activating polypeptide 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=116|116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18509|P18509]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADCYAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADCYAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:O70176, ECO:0000250|UniProtKB:P13589, ECO:0000269|PubMed:11175907, ECO:0000269|PubMed:23800469}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of acute inflammatory response to non-antigenic stimulus|
|pituitary adenylate cyclase activating polypeptide activity|
|pituitary adenylate cyclase-activating polypeptide receptor binding|
|regulation of somatostatin secretion|
|positive regulation of somatostatin secretion|
|regulation of acute inflammatory response to non-antigenic stimulus|
|positive regulation of chemokine (C-C motif) ligand 5 production|
|negative regulation of acute inflammatory response to antigenic stimulus|
|histamine secretion|
|histamine transport|
|regulation of oligodendrocyte progenitor proliferation|
|positive regulation of growth hormone secretion|
|regulation of chemokine (C-C motif) ligand 5 production|
|peptide hormone receptor binding|
|negative regulation of acute inflammatory response|
|negative regulation of inflammatory response to antigenic stimulus|
|regulation of acute inflammatory response to antigenic stimulus|
|regulation of growth hormone secretion|
|negative regulation of glial cell proliferation|
|azole transport|
|positive regulation of cAMP-mediated signaling|
|regulation of inflammatory response to antigenic stimulus|
|neuropeptide hormone activity|
|behavioral fear response|
|regulation of glial cell proliferation|
|behavioral defense response|
|positive regulation of synaptic transmission, glutamatergic|
|negative regulation of potassium ion transport|
|fear response|
|negative regulation of muscle cell apoptotic process|
|insulin secretion|
|activation of adenylate cyclase activity|
|negative regulation of gliogenesis|
|pituitary gland development|
|regulation of acute inflammatory response|
|negative regulation of GTPase activity|
|regulation of cAMP-mediated signaling|
|terminal bouton|
|ovarian follicle development|
|ammonium transport|
|cellular response to glucocorticoid stimulus|
|positive regulation of chemokine production|
|positive regulation of blood vessel diameter|
|peptide hormone secretion|
|cellular response to corticosteroid stimulus|
|regulation of muscle cell apoptotic process|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|hormone secretion|
|sensory perception of pain|
|diencephalon development|
|regulation of chemokine production|
|hormone transport|
|regulation of neural precursor cell proliferation|
|female gonad development|
|development of primary female sexual characteristics|
|positive regulation of interleukin-6 production|
|regulation of potassium ion transport|
|positive regulation of peptide hormone secretion|
|positive regulation of cold-induced thermogenesis|
|regulation of postsynaptic membrane potential|
|neuropeptide signaling pathway|
|female sex differentiation|
|regulation of gliogenesis|
|endocrine system development|
|response to ethanol|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|perikaryon|
|negative regulation of inflammatory response|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of interleukin-6 production|
|regulation of tube size|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of cold-induced thermogenesis|
|response to glucocorticoid|
|negative regulation of ion transport|
|cAMP-mediated signaling|
|negative regulation of immune response|
|positive regulation of synaptic transmission|
|protein secretion|
|establishment of protein localization to extracellular region|
|response to corticosteroid|
|protein localization to extracellular region|
|signal release|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|neurotransmitter transport|
|female pregnancy|
|cellular response to steroid hormone stimulus|
|response to starvation|
|ATP metabolic process|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gonad development|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|response to alcohol|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|sex differentiation|
|regulation of hormone secretion|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|response to antibiotic|
|negative regulation of nervous system development|
|neuron projection|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|signaling receptor binding|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|forebrain development|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|gland development|
|positive regulation of GTPase activity|
|reproductive structure development|
|reproductive system development|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to nutrient levels|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to lipid|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|behavior|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cation transport|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|secretion by cell|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADCYAP1 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>