ADGB [The Human Chemical-Genetic Interaction Map Project]

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======= ADGB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGB
  * **<color #00a2e8>Official Name</color>**: androglobin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79747|79747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N7X0|Q8N7X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADGB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADGB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent cysteine-type endopeptidase activity|
|oxygen binding|
|heme binding|
|proteolysis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.76|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.76|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.75|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADGB Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>