ADH4 [The Human Chemical-Genetic Interaction Map Project]

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======= ADH4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADH4
  * **<color #00a2e8>Official Name</color>**: alcohol dehydrogenase 4 (class II), pi polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127|127]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08319|P08319]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADH4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADH4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH N|
|ADH zinc N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|benzaldehyde dehydrogenase activity|
|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|
|S-(hydroxymethyl)glutathione dehydrogenase activity|
|all-trans retinal binding|
|ethanol binding|
|formaldehyde catabolic process|
|NADPH:quinone reductase activity|
|formaldehyde metabolic process|
|alcohol dehydrogenase (NAD) activity|
|cellular detoxification of aldehyde|
|alcohol dehydrogenase activity, zinc-dependent|
|cellular response to aldehyde|
|aldehyde catabolic process|
|ethanol oxidation|
|alditol:NADP+ 1-oxidoreductase activity|
|retinol binding|
|retinol dehydrogenase activity|
|ethanol metabolic process|
|quinone metabolic process|
|NAD binding|
|retinol metabolic process|
|antibiotic catabolic process|
|cellular aldehyde metabolic process|
|alcohol catabolic process|
|cellular ketone metabolic process|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|detoxification|
|isoprenoid metabolic process|
|hormone metabolic process|
|cellular response to toxic substance|
|alcohol metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|regulation of hormone levels|
|zinc ion binding|
|cellular lipid metabolic process|
|oxidation-reduction process|
|cellular response to oxygen-containing compound|
|lipid metabolic process|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14773
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADH4 Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>