ADH5 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= ADH5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADH5
  * **<color #00a2e8>Official Name</color>**: alcohol dehydrogenase 5 (class III), chi polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=128|128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11766|P11766]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADH5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADH5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103710|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH N|
|ADH zinc N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formaldehyde dehydrogenase activity|
|S-(hydroxymethyl)glutathione dehydrogenase activity|
|formaldehyde catabolic process|
|formaldehyde metabolic process|
|protein nitrosylation|
|peptidyl-cysteine S-nitrosylation|
|cellular detoxification of aldehyde|
|alcohol dehydrogenase activity, zinc-dependent|
|response to nitrosative stress|
|cellular response to aldehyde|
|aldehyde catabolic process|
|ethanol oxidation|
|respiratory system process|
|response to redox state|
|ethanol metabolic process|
|fatty acid binding|
|positive regulation of blood pressure|
|peptidyl-cysteine modification|
|respiratory gaseous exchange by respiratory system|
|antibiotic catabolic process|
|cellular aldehyde metabolic process|
|electron transfer activity|
|primary alcohol metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|detoxification|
|isoprenoid metabolic process|
|electron transport chain|
|regulation of blood pressure|
|cellular response to toxic substance|
|response to lipopolysaccharide|
|alcohol metabolic process|
|response to molecule of bacterial origin|
|blood circulation|
|circulatory system process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|response to bacterium|
|zinc ion binding|
|response to lipid|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|cellular lipid metabolic process|
|oxidation-reduction process|
|cellular response to oxygen-containing compound|
|lipid metabolic process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADH5 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>