ADH7 [The Human Chemical-Genetic Interaction Map Project]

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======= ADH7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADH7
  * **<color #00a2e8>Official Name</color>**: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=131|131]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40394|P40394]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADH7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADH7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ADH zinc N|
|ADH N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty acid omega-oxidation|
|aldehyde oxidase activity|
|ethanol binding|
|alcohol dehydrogenase (NAD) activity|
|alcohol dehydrogenase activity, zinc-dependent|
|ethanol oxidation|
|ethanol catabolic process|
|retinol binding|
|primary alcohol catabolic process|
|ethanol metabolic process|
|retinol dehydrogenase activity|
|receptor antagonist activity|
|retinoic acid metabolic process|
|retinol metabolic process|
|antibiotic catabolic process|
|alcohol catabolic process|
|negative regulation of signaling receptor activity|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|fatty acid oxidation|
|lipid oxidation|
|retinoid metabolic process|
|antibiotic metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|response to ethanol|
|isoprenoid metabolic process|
|drug catabolic process|
|regulation of signaling receptor activity|
|lipid modification|
|hormone metabolic process|
|response to alcohol|
|response to antibiotic|
|alcohol metabolic process|
|fatty acid metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|response to bacterium|
|zinc ion binding|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|negative regulation of molecular function|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.29|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.96|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.94|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15168
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADH7 Expression in NALM6 Cells: -0.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>