ADORA1 [The Human Chemical-Genetic Interaction Map Project]

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======= ADORA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADORA1
  * **<color #00a2e8>Official Name</color>**: adenosine A1 receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134|134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30542|P30542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADORA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADORA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of nucleoside transport|
|regulation of nucleoside transport|
|neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration|
|negative regulation of mucus secretion|
|negative regulation of neurotrophin production|
|negative regulation of circadian sleep/wake cycle, non-REM sleep|
|purine nucleoside binding|
|negative regulation of long-term synaptic depression|
|regulation of neurotrophin production|
|negative regulation of renal sodium excretion|
|heterotrimeric G-protein binding|
|negative regulation of glutamate secretion|
|negative regulation of circadian sleep/wake cycle, sleep|
|G protein-coupled adenosine receptor activity|
|negative regulation of synaptic transmission, GABAergic|
|relaxation of vascular smooth muscle|
|relaxation of smooth muscle|
|regulation of circadian sleep/wake cycle, non-REM sleep|
|adenosine receptor signaling pathway|
|positive regulation of nucleobase-containing compound transport|
|negative regulation of synaptic transmission, glutamatergic|
|regulation of mucus secretion|
|negative regulation of amino acid transport|
|positive regulation of epidermal growth factor-activated receptor activity|
|regulation of glomerular filtration|
|negative regulation of long-term synaptic potentiation|
|negative regulation of acute inflammatory response|
|regulation of respiratory gaseous exchange by nervous system process|
|negative regulation of smooth muscle contraction|
|axolemma|
|fatty acid homeostasis|
|regulation of long-term synaptic depression|
|positive regulation of systemic arterial blood pressure|
|negative regulation of circadian rhythm|
|detection of temperature stimulus involved in sensory perception|
|detection of temperature stimulus involved in sensory perception of pain|
|regulation of glutamate secretion|
|renal system process involved in regulation of blood volume|
|regulation of respiratory system process|
|regulation of nucleobase-containing compound transport|
|negative regulation of behavior|
|regulation of presynaptic cytosolic calcium ion concentration|
|regulation of circadian sleep/wake cycle, sleep|
|negative regulation of systemic arterial blood pressure|
|detection of temperature stimulus|
|G protein-coupled purinergic receptor signaling pathway|
|G-protein beta/gamma-subunit complex binding|
|negative regulation of organic acid transport|
|regulation of circadian sleep/wake cycle|
|relaxation of muscle|
|regulation of renal sodium excretion|
|sensory perception of temperature stimulus|
|negative regulation of muscle contraction|
|regulation of respiratory gaseous exchange|
|negative regulation of lipid catabolic process|
|regulation of excretion|
|positive regulation of lipid catabolic process|
|negative regulation of heart contraction|
|calyx of Held|
|renal system process involved in regulation of systemic arterial blood pressure|
|negative regulation of amine transport|
|regulation of epidermal growth factor-activated receptor activity|
|purinergic receptor signaling pathway|
|negative regulation of anion transport|
|temperature homeostasis|
|vasodilation|
|positive regulation of epidermal growth factor receptor signaling pathway|
|regulation of amino acid transport|
|regulation of synaptic transmission, GABAergic|
|positive regulation of ERBB signaling pathway|
|negative regulation of blood circulation|
|neuron cellular homeostasis|
|positive regulation of signaling receptor activity|
|regulation of renal system process|
|acylglycerol homeostasis|
|presynaptic active zone|
|triglyceride homeostasis|
|positive regulation of blood pressure|
|regulation of cardiac muscle cell contraction|
|regulation of sensory perception of pain|
|negative regulation of blood vessel diameter|
|regulation of sensory perception|
|regulation of actin filament-based movement|
|regulation of long-term synaptic potentiation|
|positive regulation of protein dephosphorylation|
|regulation of acute inflammatory response|
|positive regulation of potassium ion transport|
|negative regulation of blood pressure|
|integral component of postsynaptic membrane|
|negative regulation of leukocyte migration|
|terminal bouton|
|activation of MAPKK activity|
|regulation of lipid catabolic process|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of blood vessel diameter|
|anion homeostasis|
|integral component of presynaptic membrane|
|regulation of organic acid transport|
|heat shock protein binding|
|positive regulation of dephosphorylation|
|regulation of smooth muscle contraction|
|negative regulation of synaptic transmission|
|excitatory postsynaptic potential|
|negative regulation of hormone secretion|
|G protein-coupled receptor binding|
|chemical synaptic transmission, postsynaptic|
|regulation of synaptic transmission, glutamatergic|
|regulation of behavior|
|sensory perception of pain|
|regulation of cardiac muscle contraction|
|negative regulation of lipid metabolic process|
|regulation of epidermal growth factor receptor signaling pathway|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|regulation of striated muscle contraction|
|positive regulation of neuron death|
|regulation of amine transport|
|regulation of systemic arterial blood pressure|
|regulation of potassium ion transport|
|regulation of anion transport|
|regulation of postsynaptic membrane potential|
|renal system process|
|regulation of circadian rhythm|
|detection of external stimulus|
|detection of abiotic stimulus|
|lipid homeostasis|
|negative regulation of inflammatory response|
|regulation of nervous system process|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|regulation of protein dephosphorylation|
|positive regulation of lipid metabolic process|
|negative regulation of ion transport|
|dendritic spine|
|positive regulation of synaptic transmission|
|protein targeting to membrane|
|regulation of muscle contraction|
|vascular process in circulatory system|
|regulation of signaling receptor activity|
|response to temperature stimulus|
|regulation of blood pressure|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte migration|
|basolateral plasma membrane|
|negative regulation of secretion by cell|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of dephosphorylation|
|negative regulation of secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|postsynaptic density|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|establishment of protein localization to membrane|
|regulation of hormone secretion|
|negative regulation of cell motility|
|positive regulation of ion transport|
|apoptotic signaling pathway|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|lipid catabolic process|
|cognition|
|muscle system process|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|regulation of neuron death|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|phagocytosis|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|response to hypoxia|
|protein targeting|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|neuronal cell body|
|response to oxygen levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|positive regulation of catabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|negative regulation of immune system process|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|protein localization to membrane|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|detection of stimulus involved in sensory perception|
|cellular metal ion homeostasis|
|positive regulation of kinase activity|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|detection of stimulus|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|apoptotic process|
|sensory perception|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular protein transport|
|regulation of catabolic process|
|negative regulation of cell death|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.08|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.97|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.82|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.462|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10582
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADORA1 Expression in NALM6 Cells: -1.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>