ADRA1B [The Human Chemical-Genetic Interaction Map Project]

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======= ADRA1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRA1B
  * **<color #00a2e8>Official Name</color>**: adrenoceptor alpha 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=147|147]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35368|P35368]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRA1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRA1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha1-adrenergic receptor activity|
|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|
|neuron-glial cell signaling|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|adrenergic receptor activity|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|positive regulation of smooth muscle contraction|
|vasoconstriction|
|positive regulation of vasoconstriction|
|positive regulation of blood pressure|
|negative regulation of blood vessel diameter|
|positive regulation of muscle contraction|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|positive regulation of blood circulation|
|caveola|
|regulation of cardiac muscle contraction|
|regulation of striated muscle contraction|
|regulation of systemic arterial blood pressure|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|cAMP-mediated signaling|
|regulation of muscle contraction|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|regulation of anatomical structure size|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|cellular homeostasis|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.97|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.86|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.83|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.82|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13489
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRA1B Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>