ADRM1 [The Human Chemical-Genetic Interaction Map Project]

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======= ADRM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADRM1
  * **<color #00a2e8>Official Name</color>**: adhesion regulating molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11047|11047]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16186|Q16186]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ADRM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ADRM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610650|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. {ECO:0000269|PubMed:16815440, ECO:0000269|PubMed:16906146, ECO:0000269|PubMed:16990800, ECO:0000269|PubMed:17139257, ECO:0000269|PubMed:18497817, ECO:0000269|PubMed:24752541, ECO:0000269|PubMed:25702870, ECO:0000269|PubMed:25702872}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Proteasom Rpn13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endopeptidase activator activity|
|proteasome regulatory particle, lid subcomplex|
|proteasome assembly|
|proteasome binding|
|proteasome complex|
|transcription elongation from RNA polymerase II promoter|
|ubiquitin binding|
|DNA-templated transcription, elongation|
|protease binding|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|protein deubiquitination|
|protein modification by small protein removal|
|positive regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|transcription by RNA polymerase II|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein catabolic process|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|regulation of hydrolase activity|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.52|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.35|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.23|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.1|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.02|
|[[:results:exp539|42°C R08 exp539]]|-1.84|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.75|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.73|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.72|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.7|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.81|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps16|RPS16]]|0.51|
|[[:human genes:r:rps3a|RPS3A]]|0.478|
|[[:human genes:p:psma6|PSMA6]]|0.476|
|[[:human genes:p:psmd11|PSMD11]]|0.466|
|[[:human genes:z:zfand5|ZFAND5]]|0.464|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.462|
|[[:human genes:s:smg7|SMG7]]|0.458|
|[[:human genes:r:rpl8|RPL8]]|0.451|
|[[:human genes:d:ddx56|DDX56]]|0.451|
|[[:human genes:p:psmd1|PSMD1]]|0.45|
|[[:human genes:v:vasn|VASN]]|0.446|
|[[:human genes:c:c19orf53|C19orf53]]|0.444|
|[[:human genes:p:paf1|PAF1]]|0.443|
|[[:human genes:r:rps3|RPS3]]|0.44|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.435|
|[[:human genes:h:hap1|HAP1]]|0.434|
|[[:human genes:p:psmc2|PSMC2]]|0.433|
|[[:human genes:r:rps19|RPS19]]|0.426|
|[[:human genes:r:rpsa|RPSA]]|0.425|
|[[:human genes:r:rps11|RPS11]]|0.424|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.422|
|[[:human genes:i:ik|IK]]|0.422|
|[[:human genes:w:wdr43|WDR43]]|0.419|
|[[:human genes:p:pan3|PAN3]]|0.418|
|[[:human genes:r:rps14|RPS14]]|0.418|
|[[:human genes:r:rpl14|RPL14]]|0.415|
|[[:human genes:p:psmc1|PSMC1]]|0.414|
|[[:human genes:p:pole|POLE]]|0.413|
|[[:human genes:c:ccna2|CCNA2]]|0.41|
|[[:human genes:r:rpl18|RPL18]]|0.41|
|[[:human genes:r:rps5|RPS5]]|0.409|
|[[:human genes:r:rps7|RPS7]]|0.409|
|[[:human genes:n:nop16|NOP16]]|0.404|
|[[:human genes:p:pan2|PAN2]]|0.404|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.404|
|[[:human genes:p:psma7|PSMA7]]|0.403|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.403|
|[[:human genes:c:ckap5|CKAP5]]|0.403|
|[[:human genes:r:rps12|RPS12]]|0.403|
|[[:human genes:b:bysl|BYSL]]|0.402|
|[[:human genes:t:terf2|TERF2]]|0.402|
|[[:human genes:p:psmc6|PSMC6]]|0.401|
|[[:human genes:z:znf106|ZNF106]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 28/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/25|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/14|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1541
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ADRM1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>