AFP [The Human Chemical-Genetic Interaction Map Project]

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======= AFP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AFP
  * **<color #00a2e8>Official Name</color>**: alpha fetoprotein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=174|174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02771|P02771]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AFP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AFP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serum albumin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ovulation from ovarian follicle|
|progesterone metabolic process|
|ovulation|
|C21-steroid hormone metabolic process|
|ovulation cycle process|
|SMAD protein signal transduction|
|ovulation cycle|
|cellular ketone metabolic process|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|cellular hormone metabolic process|
|female gamete generation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|hormone metabolic process|
|gonad development|
|development of primary sexual characteristics|
|steroid metabolic process|
|sex differentiation|
|rhythmic process|
|endoplasmic reticulum lumen|
|post-translational protein modification|
|reproductive structure development|
|reproductive system development|
|drug metabolic process|
|regulation of hormone levels|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|lipid metabolic process|
|reproductive process|
|reproduction|
|extracellular space|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.73|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.04|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18519
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AFP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>